Volume 13; Issue 7

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Bioorganic & Medicinal Chemistry Letters
Volume 13; Issue 7

Bioorganic & Medicinal Chemistry Letters

Volume 13; Issue 7

1

Novel and potent human and rat β3-Adrenergic receptor agonists containing substituted 3-indolylalkylamines

Hiroshi Harada, Yoshimi Hirokawa, Kenji Suzuki, Yoichi Hiyama, Mayumi Oue, Hitoshi Kawashima, Naoyuki Yoshida, Yasuji Furutani, Shiro Kato

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

2

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Richard L. Jarvest, John M. Berge, Pamela Brown, Catherine S.V. Houge-Frydrych, Peter J. O'Hanlon, David J. McNair, Andrew J. Pope, Stephen Rittenhouse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 185 KB

english, 2003

3

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency

Stephen L. Gwaltney II, Stephen J. O'Connor, Lissa T.J. Nelson, Gerard M. Sullivan, Hovis Imade, Weibo Wang, Lisa Hasvold, Qun Li, Jerome Cohen, Wen-Zhen Gu, Stephen K. Tahir, Joy Bauch, Kennan Marsh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

4

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

Stephen L. Gwaltney II, Stephen J. O'Connor, Lissa T.J. Nelson, Gerard M. Sullivan, Hovis Imade, Weibo Wang, Lisa Hasvold, Qun Li, Jerome Cohen, Wen-Zhen Gu, Stephen K. Tahir, Joy Bauch, Kennan Marsh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 331 KB

english, 2003

5

Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase

Michael L. Curtin, Alan S. Florjancic, Jerome Cohen, Wen-Zhen Gu, David J. Frost, Steven W. Muchmore, Hing L. Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

6

Photoinduced DNA cleavage by benzenediradical equivalents: 1,3- and 1,4-Bis(dicarbonylcyclopentadienyliron)benzene

Debra L. Mohler, Janet Gray Coonce, Daniel Predecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 148 KB

english, 2003

7

Adsorbed surfactants for affinity chromatography: end-group modification of ethylene glycol polymers

Cemile Yaniç, Martin W. Bredenkamp, Edmund P. Jacobs, Pieter Swart

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 130 KB

english, 2003

8

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle, Philippe G. Nantermet, Harold G. Selnick, Richard C.A. Isaacs, S.Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Rominder Singh, Cynthia Miller-St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 255 KB

english, 2003

9

Inhibition of telomerase by BIBR 1532 and related analogues

D.K Barma, Anissa Elayadi, J.R Falck, David R Corey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

10

Dermorphin tetrapeptide analogues with 2′,6′-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high μ opioid receptor binding and biological activities1

Akihiro Ambo, Hideko Niizuma, Ai Sasaki, Hirokazu Kohara, Yusuke Sasaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 138 KB

english, 2003

11

Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp.

Suppamit Dettrakul, Prasat Kittakoop, Masahiko Isaka, Sombat Nopichai, Chotika Suyarnsestakorn, Morakot Tanticharoen, Yodhathai Thebtaranonth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 137 KB

english, 2003

12

Synthesis of low molecular weight compounds with complement inhibition activity

Hoshang E Master, Shabana I Khan, Krishna A Poojari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

13

Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine

Liantao Li, Julia Kracht, Shiqi Peng, Günther Bernhardt, Armin Buschauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

14

Structure–activity relationship of cyclic peptide penta-c[Asp-His6-DPhe7-Arg8-Trp9-Lys]-NH2 at the human melanocortin-1 and -4 receptors: His6 substitution

Adrian Wai-Hing Cheung, Waleed Danho, Joseph Swistok, Lida Qi, Grazyna Kurylko, Karen Rowan, Mitch Yeon, Lucia Franco, Xin-Jie Chu, Li Chen, Keith Yagaloff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

15

Phenylacetic acid derivatives as hPPAR agonists

Conrad Santini, Gregory D Berger, Wei Han, Ralph Mosley, Karen MacNaul, Joel Berger, Thomas Doebber, Margaret Wu, David E Moller, Richard L Tolman, Soumya P Sahoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

16

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

David R Magnin, Scott A Biller, John Wetterau, Jeffrey A Robl, John K Dickson Jr., Prakash Taunk, Thomas W Harrity, R.Michael Lawrence, C.-Q Sun, Tammy Wang, Janette Logan, Olga Fryszman, Fergal Conno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

17

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the syk SH2 domains with equally high affinity as the natural ligand

Frank J Dekker, Nico J de Mol, Marcel J.E Fischer, Rob M.J Liskamp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

18

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

Ramin Faghih, Wesley Dwight, Jia Bao Pan, Gerard B. Fox, Kathy M. Krueger, Timothy A. Esbenshade, Jill M. McVey, Kennan Marsh, Youssef L. Bennani, Arthur A. Hancock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 173 KB

english, 2003

19

Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

Putta Mallikarjuna Reddy, Thomas C. Bruice

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

20

Synthesis and biological activities of phthalocyanine–estradiol conjugates

Ehtsham H. Khan, Hasrat Ali, Hongjian Tian, Jacques Rousseau, Guillame Tessier, Shafiullah, Johan E. van Lier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

21

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

Nan-Horng Lin, Le Wang, Jerry Cohen, Wen-Zhen Gu, David Frost, Haiying Zhang, Saul Rosenberg, Hing Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

22

Investigation of an antibody-ligase. evidence for strain-induced catalysis

Sergey N Savinov, Ralph Hirschmann, Stephen J Benkovic, Amos B Smith III

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

23

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Robert J Cherney, Ruowei Mo, Dayton T Meyer, Li Wang, Wenqing Yao, Zelda R Wasserman, Rui-Qin Liu, Maryanne B Covington, Micky D Tortorella, Elizabeth C Arner, Mingxin Qian, David D Christ, James M Tr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

24

[3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter

John A. Lowe III, Susan E. Drozda, Katherine Fisher, Christine Strick, Lorraine Lebel, Christopher Schmidt, Donna Hiller, Kathleen S. Zandi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 129 KB

english, 2003

25

Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay Wrobel, Richard Winneker, Zhiming Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 198 KB

english, 2003

26

Novel 5-aryl-1,3-dihydro-indole-2-thiones: potent, orally active progesterone receptor agonists

Andrew Fensome, Marci Koko, Jay Wrobel, Puwen Zhang, Zhiming Zhang, Jeffrey Cohen, Scott Lundeen, Kelly Rudnick, Yuan Zhu, Richard Winneker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

27

Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors

Guoxin Zhu, Scott Conner, Xun Zhou, Chuan Shih, Harold B. Brooks, Eileen Considine, Jack A. Dempsey, Cathy Ogg, Bharvin Patel, Richard M. Schultz, Charles D. Spencer, Beverly Teicher, Scott A. Watkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 230 KB

english, 2003

28

The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A

Marı́a L Souto, Claudia P Manrı́quez, Manuel Norte, Francisco Leira, José J Fernández

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

29

Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human γδ T cells but does not lead to competitive antagonism

Armin Reichenberg, Martin Hintz, Yvonne Kletschek, Tanja Kuhl, Christian Haug, Rosel Engel, Jens Moll, Dmitry N Ostrovsky, Hassan Jomaa, Matthias Eberl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 148 KB

english, 2003

30

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 54 KB

english, 2003

31

Contributors to this Issue - 3 page

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

File:

PDF, 43 KB

2003

32

Graphical Abstracts - 9 pages

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 307 KB

english, 2003

33

Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens

Michel Tabart, Guy Picaut, Marc Lavergne, Sylvie Wentzler, Jean-Luc Malleron, Sylvie Dutka-Malen, Nadine Berthaud

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003

34

Azalide 3,6-Ketals: antibacterial activity and structure–Activity relationships of aryl and hetero aryl substituted analogues

Subas M Sakya, Peter Bertinato, Bryan Pratt, Melani Suarez-Contreras, Kristin M Lundy, Martha L Minich, Hengmiao Cheng, Carl B Ziegler, Barbara J Kamicker, Shigeru F Hayashi, Sheryl L Santoro, David M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

35

Reaction of Thiols with 7-Methylbenzopentathiepin

Tonika Chatterji, Kent S. Gates

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

36

Synthesis and structure–Activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists

Mark A. Youngman, John R. Carson, Jung S. Lee, Scott L. Dax, Sui-Po Zhang, Ray W. Colburn, Dennis J. Stone, Ellen E. Codd, Michele C. Jetter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

37

Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors

Ping Chen, Derek Norris, Kristin D. Haslow, T.G. Murali Dhar, William J. Pitts, Scott H. Watterson, Daniel L. Cheney, Donna A. Bassolino, Catherine A. Fleener, Katherine A. Rouleau, Diane L. Hollenbau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

38

Further exploration of 1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter

David Lewis, Ying Zhang, Thomas Prisinzano, Christina M. Dersch, Richard B. Rothman, Arthur E. Jacobson, Kenner C. Rice

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

39

Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3

Scott H. Watterson, T.G.Murali Dhar, Shelley K. Ballentine, Zhongqi Shen, Joel C. Barrish, Daniel Cheney, Catherine A. Fleener, Katherine A. Rouleau, Robert Townsend, Diane L. Hollenbaugh, Edwin J. Iw

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 210 KB

english, 2003

40

A new synthesis of cytoxazone and its diastereomers provides key initial SAR information

Percy H. Carter, Jacob R. LaPorte, Peggy A. Scherle, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

41

Corrigendum to “synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells”: [Bioorg. Med. Chem. Lett. 13 (2003) 613]

Keiji Shikata, Hayato Niiro, Hideki Azuma, Taro Tachibana, Kenji Ogino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

42

Contents List - 3 pages

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 229 KB

english, 2003

43

Instructions to Contributors and GA example

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

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