Volume 14; Issue 17

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Bioorganic & Medicinal Chemistry Letters
Volume 14; Issue 17

Bioorganic & Medicinal Chemistry Letters

Volume 14; Issue 17

1

Non-peptide oxytocin agonists

Gary Pitt, Andrzej Batt, Robert Haigh, Andrew Penson, Peter Robson, David Rooker, André Tartar, Julie Trim, Christopher Yea, Michael Roe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

2

Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors

Manik R Pullagurla, Richard B Westkaemper, Richard A Glennon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 374 KB

english, 2004

3

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

Ahmed Kamal, Mahendra Sandbhor, Ahmad Ali Shaik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 258 KB

english, 2004

4

Discovery of new chemical leads for prostaglandin D2 receptor antagonists

Kazuhiko Torisu, Kaoru Kobayashi, Maki Iwahashi, Hiromu Egashira, Yoshihiko Nakai, Yutaka Okada, Fumio Nanbu, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

5

Design, synthesis, and biochemical evaluation of novel αvβ3 integrin ligands

Juan Jose Marugan, Kristin D Haslow, Carl Crysler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 250 KB

english, 2004

6

Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives

Ling Wei, Joseph P Steiner, Gregory S Hamilton, Yong-Qian Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

7

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides

Yong-Jin Wu, Li-Qiang Sun, Huan He, Jie Chen, John E Starrett Jr., Pierre Dextraze, Jean-Paul Daris, Christopher G Boissard, Rick L Pieschl, Valentin K Gribkoff, Joanne Natale, Ronald J Knox, David G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 323 KB

english, 2004

8

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey

Robert D Selliah, Mark R Hellberg, Najam A Sharif, Marsha A McLaughlin, Gary W Williams, Daniel A Scott, David Earnest, Karen S Haggard, W Dennis Dean, Pete Delgado, Michael S Gaines, Raymond E Conrow

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

9

Nonpeptide αvβ3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative

Michael J Breslin, Mark E Duggan, Wasyl Halczenko, George D Hartman, Le T Duong, Carmen Fernandez-Metzler, Michael A Gentile, Donald B Kimmel, Chih-Tai Leu, Kara Merkle, Thomayant Prueksaritanont, Gid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

10

The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds

Daniel Fernández, Mary Anne Wenck, Sydney P Craig III, José M Delfino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 308 KB

english, 2004

11

Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics

Todd C. Henninger, Xiaodong Xu, Darren Abbanat, Ellen Z. Baum, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Dennis J. Hlasta, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 294 KB

english, 2004

12

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents

Jin Hee Ahn, Hye-Min Kim, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Sung-Don Yang, Hyae Gyeong Cheon, Sung Soo Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

13

Anti-HIV activity of some synthetic lignanolides and intermediates

Rocı́o Sancho, Manuel Medarde, Sonsoles Sánchez-Palomino, Blanca M Madrigal, José Alcamı́, Eduardo Muñoz, Arturo San Feliciano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

14

Synthesis and structure–activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Chu-Biao Xue, Xiao-Tao Chen, Xiaohua He, John Roderick, Ronald L. Corbett, Bahman Ghavimi, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Maria D. Ribadeneira, Krishna Vaddi, James Trzaskos, Robert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 310 KB

english, 2004

15

4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle

Piyasena Hewawasam, Wenhong Fan, Deborah A. Cook, Kimberly S. Newberry, Christopher G. Boissard, Valentin K. Gribkoff, John Starrett, Nicholas J. Lodge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

16

Synthesis of chiral phosphoantigens and their activity in γδ T cell stimulation

Yongcheng Song, Yonghui Zhang, Hong Wang, Amy Raker, John Sanders, Erin Broderick, Allen Clark, Craig Morita, Eric Oldfield

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 375 KB

english, 2004

17

Structure–activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity

Yoko Nagumo, Hideaki Kakeya, Junichiro Yamaguchi, Takao Uno, Mitsuru Shoji, Yujiro Hayashi, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

18

Synthesis and cellular uptake of a fluorescently labeled cyclic PNA-based compound

Sergio Caldarelli, Geoffrey Depecker, Nadia Patino, Audrey Di Giorgio, Thibault Barouillet, Alain Doglio, Roger Condom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

19

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors

Rune Ringom, Eva Axen, Jonas Uppenberg, Thomas Lundbäck, Lena Rondahl, Tjeerd Barf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 361 KB

english, 2004

20

Structure–activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor

Joseph Pontillo, Joseph A. Tran, Melissa Arellano, Beth A. Fleck, Rajesh Huntley, Dragan Marinkovic, Marion Lanier, Jodie Nelson, Jessica Parker, John Saunders, Fabio C. Tucci, Wanlong Jiang, Caroline

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

21

Stereoselective synthesis and preliminary evaluation of new d-3-heteroarylcarbonylalanines as ligands of the NMDA receptor

Paulo G. Lima, Rodrigo R.B. Caruso, Simone O. Alves, Renata F. Pessôa, Dayde L. Mendonça-Silva, Ricardo J. Nunes, François Noël, Newton G. Castro, Paulo R.R. Costa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 286 KB

english, 2004

22

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, H.D. Hollis Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides, Rajeshwar Singh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

23

Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog

Roger Léger, Karen Thibaudeau, Martin Robitaille, Omar Quraishi, Pieter van Wyk, Nathalie Bousquet-Gagnon, Julie Carette, Jean-Paul Castaigne, Dominique P. Bridon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

24

Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone

David B. Whitman, Ben C. Askew, Le T. Duong, Carmen Fernandez-Metzler, Wasyl Halczenko, George D. Hartman, John H. Hutchinson, Chih-Tai Leu, Thomayant Prueksaritanont, Gideon A. Rodan, Sevgi B. Rodan,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 257 KB

english, 2004

25

Synthesis of 2′,5′-oligoadenylate analogs containing an adenine acyclonucleoside and their ability to activate human RNase L

Yoshihito Ueno, Shinji Ishihara, Yasutomo Ito, Yukio Kitade

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 310 KB

english, 2004

26

Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions

Alessio Innocenti, Sabrina Zimmerman, James Ferry, Andrea Scozzafava, Claudiu Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 292 KB

english, 2004

27

Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids

Toh-Seok Kam, Kooi-Mow Sim, Huey-Shen Pang, Takashi Koyano, Masahiko Hayashi, Kanki Komiyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

28

Discovery of potent and orally bioavailable N,N′-diarylurea antagonists for the CXCR2 chemokine receptor

Qi Jin, Hong Nie, Brent W. McCleland, Katherine L. Widdowson, Michael R. Palovich, John D. Elliott, Richard M. Goodman, Miriam Burman, Henry M. Sarau, Keith W. Ward, Melanie Nord, Bonnie M. Orr, Peter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

29

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

30

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 537 KB

english, 2004

31

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

File:

PDF, 190 KB

2004

32

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

33

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

K Shankaran, Karla L Donnelly, Shrenik K Shah, Ravindra N Guthikonda, Malcolm MacCoss, John L Humes, Stephen G Pacholok, Stephan K Grant, T.M Kelly, K.K Wong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

34

Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

Jean Jacques Vanden Eynde, Annie Mayence, Tien L Huang, Margaret S Collins, Sandra Rebholz, Peter D Walzer, Melanie T Cushion

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

35

Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity

Dong-Yun Shin, Sun Nam Kim, Jung-Hyun Chae, Soon-Sil Hyun, Seung-Yong Seo, Yong-Sil Lee, Kwang-Ok Lee, Seok-Ho Kim, Yun-Sang Lee, Jae Min Jeong, Nam-Song Choi, Young-Ger Suh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

36

Isoindolinone ureas: a novel class of KDR kinase inhibitors

Michael L Curtin, Robin R Frey, H.Robin Heyman, Kathy A Sarris, Douglas H Steinman, James H Holmes, Peter F Bousquet, George A Cunha, Maria D Moskey, Asma A Ahmed, Lori J Pease, Keith B Glaser, Kent D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 321 KB

english, 2004

37

Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide

Hiroaki Taguchi, Zhenyong Keck, Steven K.H Foung, Sudhir Paul, Yasuhiro Nishiyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

38

A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation

Vincenzo Santagada, Francesco Frecentese, Elisa Perissutti, Donatella Cirillo, Sara Terracciano, Giuseppe Caliendo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 247 KB

english, 2004

39

Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity

Kenneth M. Boy, Michael Dee, Joseph Yevich, John Torrente, Qi Gao, Lawrence Iben, Arlene Stark, Ronald J. Mattson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

40

Design, synthesis and antimalarial activity of a glyoxylylhydrazone library

A. Ryckebusch, J.-S. Fruchart, L. Cattiaux, P. Rousselot-Paillet, V. Leroux, O. Melnyk, P. Grellier, E. Mouray, C. Sergheraert, P. Melnyk

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

41

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target

Fredik Lehmann, Saba Haile, Eva Axen, Carmen Medina, Jonas Uppenberg, Stefan Svensson, Thomas Lundbäck, Lena Rondahl, Tjeerd Barf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 308 KB

english, 2004

42

Synthesis of an unusual branched-chain sugar, 5-C-methyl-l-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics

Jinhua Wang, Jie Li, Przemyslaw G. Czyryca, Huiwen Chang, Jeff Kao, Cheng-Wei Tom Chang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 353 KB

english, 2004

43

A library synthesis of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as anti-tumor agents

Ichiro Hayakawa, Rieko Shioya, Toshinori Agatsuma, Hidehiko Furukawa, Shunji Naruto, Yuichi Sugano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 282 KB

english, 2004

44

Synthesis, receptor binding and functional studies of mesoridazine stereoisomers

Sungwoon Choi, Deborah Haggart, Lawrence Toll, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

45

Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential

Kiran Kumar Kothakonda, D. Subhas Bose

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 254 KB

english, 2004

46

SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease

Savina Malancona, Stefania Colarusso, Jesus M Ontoria, Antonella Marchetti, Marco Poma, Ian Stansfield, Ralph Laufer, Annalise Di Marco, Marina Taliani, Maria Verdirame, Odalys Gonzalez-Paz, Victor G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

47

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

Deane M Nason, Steven D Heck, Mathew S Bodenstein, John A Lowe III, Robert B Nelson, Dane R Liston, Charles E Nolan, Lorraine F Lanyon, Karen M Ward, Robert A Volkmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

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