Volume 14; Issue 20

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Bioorganic & Medicinal Chemistry Letters
Volume 14; Issue 20

Bioorganic & Medicinal Chemistry Letters

Volume 14; Issue 20

1

Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa

Sochanchingwung Rumthao, Oukseub Lee, Qi Sheng, WenTao Fu, Debbie C. Mulhearn, David Crich, Andrew D. Mesecar, Michael E. Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 385 KB

english, 2004

2

Benzopyranones with retro-amide side chains as (inhibitory) β-lactamase substrates

S.A. Adediran, D. Cabaret, J.-F. Lohier, M. Wakselman, R.F. Pratt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

3

Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones

Jyh-Haur Chern, Chung-Chi Lee, Chih-Shiang Chang, Yen-Chun Lee, Chia-Liang Tai, Ying-Ting Lin, Kak-Shan Shia, Ching-Yin Lee, Shin-Ru Shih

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 287 KB

english, 2004

4

Synthesis of 5a-carba-hexopyranoses and hexopyranosylamines, as well as 5a,5a′-dicarbadisaccharides, from 3,8-dioxatricyclo[4.2.1.02,4]nonan-9-ol: glycosidase inhibitory activity of N-substituted 5a-carba-β-gluco- and β-galactopyranosylamines, and derivatives thereof

Seiichiro Ogawa, Sho Funayama, Kensuke Okazaki, Fumito Ishizuka, Yoko Sakata, Fuminao Doi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 306 KB

english, 2004

5

Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group

Yasuo Takano, Futoshi Shiga, Jun Asano, Wataru Hori, Tsuyosi Anraku, Takashi Uno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 282 KB

english, 2004

6

Application of the Stille coupling reaction to the synthesis of C2-substituted endo–exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Arnaud C. Tiberghien, David Hagan, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

7

Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists

Bo Liu, Gang Liu, Zhili Xin, Micheal D. Serby, Hongyu Zhao, Verlyn G. Schaefer, H. Douglas Falls, Wiweka Kaszubska, Christine A. Collins, Hing L. Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

8

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Nilesh Shah, Thomas S. Scanlan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 354 KB

english, 2004

9

N-{2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl}acetamide: an orally bioavailable melatonin receptor agonist

Li-Qiang Sun, Katherine Takaki, Jie Chen, Lawrence Iben, Jay O. Knipe, Lori Pajor, Cathy D. Mahle, Elaine Ryan, Cen Xu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

10

Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Scott D. Edmondson, Anthony Mastracchio, Maria Beconi, Lawrence F. Colwell Jr., Bahanu Habulihaz, Huaibing He, Sanjeev Kumar, Barbara Leiting, Kathryn A. Lyons, Ann Mao, Frank Marsilio, Reshma A. Pate

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

11

Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential β-cell imaging agent

Björn Wängler, Carmen Beck, Chyng Yann Shiue, Stephan Schneider, Christina Schwanstecher, Mathias Schwanstecher, Peter Johannes Feilen, Abass Alavi, Frank Rösch, Ralf Schirrmacher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 289 KB

english, 2004

12

Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists

Radhakrishnan Mahesh, Ramachandran Venkatesha Perumal, Pandi Vijaya Pandi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

13

Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors

Masahiro Tanaka, Shoichi Sagawa, Jun-ichi Hoshi, Fumito Shimoma, Isamu Matsuda, Kenji Sakoda, Tomohiko Sasase, Masanori Shindo, Takashi Inaba

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

14

Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position

Hiroaki Inagaki, Hisashi Takahashi, Makoto Takemura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

15

Biaryl guanidine inhibitors of in vitro HCV-IRES activity

Elizabeth A. Jefferson, Punit P. Seth, Dale E. Robinson, Dana K. Winter, Alycia Miyaji, Stephen A. Osgood, Eric E. Swayze, Lisa M. Risen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 300 KB

english, 2004

16

Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand

Mark A. Matulenko, Bruce Surber, Leimin Fan, Teodozyi Kolasa, Masaki Nakane, Marc A. Terranova, Marie E. Uchic, Loan N. Miller, Renjie Chang, Diana L. Donnelly-Roberts, Marian T. Namovic, Robert B. Mo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

17

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

Richard Sulsky, Jeffrey A. Robl, Scott A. Biller, Thomas W. Harrity, John Wetterau, Fergal Connolly, Kern Jolibois, Lori Kunselman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 270 KB

english, 2004

18

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives

William J. Watkins, Rémy C. Lemoine, Lee Chong, Aesop Cho, Thomas E. Renau, Bonnie Kuo, Vickie Wong, Maria Ludwikow, Negar Garizi, Nadeem Iqbal, John Barnard, Renata Jankowska, Rajeshwar Singh, Deidre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

19

Benzothiophene and naphthalene derived constrained SERMs

Owen B. Wallace, Henry U. Bryant, Pamela K. Shetler, Mary D. Adrian, Andrew G. Geiser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

20

Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid

Ian Stansfield, Salvatore Avolio, Stefania Colarusso, Nadia Gennari, Frank Narjes, Barbara Pacini, Simona Ponzi, Steven Harper

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 280 KB

english, 2004

21

Development of a polyvalent assay system for lead identification

Frank Lovering, Yvonne Angell, Yan-Ling Zhang, Kristie Bridges

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 341 KB

english, 2004

22

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

23

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

Kenneth M. Boy, Jason M. Guernon, Sing-Yuen Sit, Kai Xie, Piyasena Hewawasam, Christopher G. Boissard, Steven I. Dworetzky, Joanne Natale, Valentin K. Gribkoff, Nicholas Lodge, John E. Starrett Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

24

A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A

Kevin Tidgewell, Wayne W. Harding, Mark Schmidt, Kenneth G. Holden, Daryl J. Murry, Thomas E. Prisinzano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

25

Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors

Joseph Dudash Jr., Xiaoyan Zhang, Roxanne E. Zeck, Sigmond G. Johnson, Geoffrey G. Cox, Bruce R. Conway, Philip J. Rybczynski, Keith T. Demarest

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

26

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor

Nan-Horng Lin, Le Wang, Xilu Wang, Gary T. Wang, Jerry Cohen, Wen-Zhen Gu, Haiying Zhang, Saul H. Rosenberg, Hing L. Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

27

N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing

Sandra Castang, Bernard Chantegrel, Christian Deshayes, René Dolmazon, Patrice Gouet, Richard Haser, Sylvie Reverchon, William Nasser, Nicole Hugouvieux-Cotte-Pattat, Alain Doutheau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 494 KB

english, 2004

28

Facile incorporation of urea pseudopeptides into protease substrate analogue inhibitors

Adam C. Myers, Jennifer A. Kowalski, Mark A. Lipton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

29

Synthesis and cytotoxic activity of novel derivatives of 4′-demethylepipodophyllotoxin

Shi-Wu Chen, Xuan Tian, Yong-Qiang Tu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 270 KB

english, 2004

30

1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor

R. Richard Goehring, John F.W. Whitehead, K. Brown, Khondaker Islam, Xin Wen, Xiaoming Zhou, Zhengming Chen, Kenneth J. Valenzano, Wendy S. Miller, Shen Shan, Donald J. Kyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 299 KB

english, 2004

31

Fragmentation of Golgi membranes by norrisolide and designed analogues

Thomas P. Brady, Erin K. Wallace, Sun Hee Kim, Gianni Guizzunti, Vivek Malhotra, Emmanuel A. Theodorakis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 422 KB

english, 2004

32

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 391 KB

english, 2004

33

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 515 KB

english, 2004

34

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

File:

PDF, 188 KB

2004

35

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 74 KB

english, 2004

36

Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins

Bart L. De Corte, William A. Kinney, Li Liu, Shyamali Ghosh, Livia Brunner, William J. Hoekstra, Rosemary J. Santulli, Robert W. Tuman, Judith Baker, Candace Burns, Jef C. Proost, Brett A. Tounge, Bru

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

37

Corrigendum to “Synthesis and biological activity of some known and putative duloxetine metabolites”: [Bioorg. Med. Chem. Lett. 14 (2004) 3481]

F. Kuo, T.A. Gillespie, P. Kulanthaivel, R.J. Lantz, T.W. Ma, D.L.G. Nelson, P.G. Threlkeld, W.J. Wheeler, P. Yi, M. Zmijewski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 204 KB

english, 2004

38

Specificity of human trans-sialidase as probed with gangliosides

E.Yu. Nikonova, V.V. Tertov, C. Sato, K. Kitajima, N.V. Bovin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 286 KB

english, 2004

39

Anticancer activity of 3-O-acyl and alkyl-(−)-epicatechin derivatives

Ki Duk Park, Sul Gi Lee, Sung Uk Kim, Sung Han Kim, Won Suck Sun, Sung Jin Cho, Do Hyeon Jeong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

40

Synthesis and biological activity of novel antibacterial quinazolines

Preet M.S. Bedi, V. Kumar, Mohinder P. Mahajan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 254 KB

english, 2004

41

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

Rémy C. Lemoine, Tomasz W. Glinka, William J. Watkins, Aesop Cho, Jessie Yang, Nadeem Iqbal, Rajeshwar Singh, Deidre Madsen, Karen Lolans, Olga Lomovskaya, Uma Oza, Michael N. Dudley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 295 KB

english, 2004

42

Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I)

Aida Chircorian, Amy M. Barrios

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

43

4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Jean-Marie Receveur, Emelie Bjurling, Trond Ulven, Paul Brian Little, Pia K. Nørregaard, Thomas Högberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 301 KB

english, 2004

44

Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors

Samir Yahiaoui, Christelle Pouget, Catherine Fagnere, Yves Champavier, Gérard Habrioux, Albert José Chulia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 285 KB

english, 2004

45

Novel epicatechin derivatives with antioxidant activity modulate interleukin-1β release in lipopolysaccharide-stimulated human blood

Montserrat Mitjans, Verónica Martínez, Jaime del Campo, Celia Abajo, Carles Lozano, Josep Lluís Torres, Maria Pilar Vinardell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 270 KB

english, 2004

46

Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells

Eun-Jin Lee, Hyun-Jung Lee, Hyen Joo Park, Hye-Young Min, Myung-Eun Suh, Hwa-Jin Chung, Sang Kook Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 411 KB

english, 2004

47

Corrigendum to “Synthesis and biological activity of some known and putative duloxetine metabolites”[Bioorg. Med. Chem. Lett. 14 (2004) 3481]

KUO, F, GILLESPIE, T, KULANTHAIVEL, P, LANTZ, R, MA, T, NELSON, D, THRELKELD, P, WHEELER, W, YI, P, ZMIJEWSKI, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

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