Volume 14; Issue 24

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Bioorganic & Medicinal Chemistry Letters
Volume 14; Issue 24

Bioorganic & Medicinal Chemistry Letters

Volume 14; Issue 24

1

Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

Carlos Jaramillo, J. Eugenio de Diego, Chafiq Hamdouchi, Elizabeth Collins, Heather Keyser, Concha Sánchez-Martı́nez, Miriam del Prado, Bryan Norman, Harold B. Brooks, Scott A. Watkins, Charles D. Spe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

2

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Justin J.J. Leahy, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Caroline Richardson, Laurent Rigoreau, Graeme C.M. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

3

QSAR modelling of HIV-1 reverse transcriptase inhibition by benzoxazinones using a combination of P_VSA and pharmacophore feature descriptors

S. Balaji, C. Karthikeyan, N.S. Hari Narayana Moorthy, Piyush Trivedi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

4

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Ali Almasirad, Sayyed A. Tabatabai, Mehrdad Faizi, Abbas Kebriaeezadeh, Nazila Mehrabi, Afshin Dalvandi, Abbas Shafiee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 247 KB

english, 2004

5

Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies

Dai-Shi Su, , M. Kristine Markowitz, Kathy L. Murphy, Bang-Lin Wan, Matthew M. Zrada, C. Meacham Harrell, Stacy S. O’Malley, J. Fred Hess, Rick W. Ransom, Ray S. Chang, Michael A. Wallace, Conrad E. R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

6

Corrigendum to “Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor”: [Bioorg. Med. Chem. Lett. 14 (2004) 4867]

Julie A. Heath, Mukund M. Mehrotra, Shannon Chi, Jin-Chen Yu, Athiwat Hutchaleelaha, Stanley J. Hollenbach, Neil A. Giese, Robert M. Scarborough, Anjali Pandey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004

7

Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists

Guanglin Luo, Gail K. Mattson, Marc A. Bruce, Henry Wong, Brian J. Murphy, Daniel Longhi, Ildiko Antal-Zimanyi, Graham S. Poindexter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

8

Evans Blue is an inhibitor of nuclear factor-kappa B (NF-κB)-DNA binding

Rakesh K. Sharma, Masami Otsuka, Vineet Pande, Jun-ichiro Inoue, Maria João Ramos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 450 KB

english, 2004

9

Chimeric cyclodepsipeptides as mimetics for the anthelmintic PF1022A

Hubert Dyker, Achim Harder, Jürgen Scherkenbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 348 KB

english, 2004

10

9-cis-Retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists

Rosana Alvarez, M. Jesús Vega, Sabrina Kammerer, Aurélie Rossin, Pierre Germain, Hinrich Gronemeyer, Angel R. de Lera

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 477 KB

english, 2004

11

Conversion of human-selective PPARα agonists to human/mouse dual agonists: a molecular modeling analysis

Minmin Wang, Leonard L. Winneroski, Robert J. Ardecky, Robert E. Babine, Dawn A. Brooks, Garret J. Etgen, Darrell R. Hutchison, Raymond F. Kauffman, Aaron Kunkel, Dale E. Mais, Chahrzad Montrose-Rafiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 295 KB

english, 2004

12

Tryptamine-based human β3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives

Masaaki Sawa, Hirotaka Tateishi, Kazuhiro Mizuno, Hiroshi Harada, Mayumi Oue, Hiroshi Tsujiuchi, Yasuji Furutani, Shiro Kato

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

13

Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase

Roy J. Vaz, Zhongli Gao, James Pribish, Xin Chen, Julian Levell, Larry Davis, Eva Albert, Maurice Brollo, Antonio Ugolini, Dona M. Cramer, Jennifer Cairns, Keith Sides, Feng Liu, Jennifer Kwong, Jiesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

14

Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates

Radhakrishnan Sridhar, Paramasivam T. Perumal, Sundaresan Etti, Guruswamy Shanmugam, Mondikalipudur N. Ponnuswamy, Vaiyapuri R. Prabavathy, Narayanasamy Mathivanan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

15

Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease

Deliang Duan, Zhengquan Li, Hongpeng Luo, Wei Zhang, Lirong Chen, Xiaojie Xu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 281 KB

english, 2004

16

Fluorescence quenching of parallel-stranded DNA bound ethidium bromide: the effect of 7-deaza-2′-deoxyisoguanosine and 7-halogenated derivatives

Hong Li, Xiaohua Peng, Frank Seela

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

17

3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors

Ramani R. Ranatunge, Richard A. Earl, David S. Garvey, David R. Janero, L. Gordon Letts, Allison M. Martino, Madhavi G. Murty, Stewart K. Richardson, David J. Schwalb, Delano V. Young, Irina S. Zemtse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

18

Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

Thierry Muller, Luc Grandbarbe, Eleonora Morga, Paul Heuschling, Bang Luu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

19

Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists

Deyi Zhang, Dan Kohlman, Joseph Krushinski, Sidney Liang, Bai-Ping Ying, John E. Reilly, Sean R. Dinn, David B. Wainscott, Suzanne Nutter, Wendy Gough, David L.G. Nelson, John M. Schaus, Yao-Chang Xu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 322 KB

english, 2004

20

Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors

Myungsok Oh, Isak Im, Yong Jae Lee, Young Hoon Kim, Jeong Hyeok Yoon, Hye Gyeong Park, Shigeki Higashiyama, Yong-Chul Kim, Woo Jin Park

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 406 KB

english, 2004

21

Improving the intein-mediated, site-specific protein biotinylation strategies both in vitro and in vivo

Lay-Pheng Tan, Rina Y.P. Lue, Grace Y.J. Chen, Shao Q. Yao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 317 KB

english, 2004

22

α-1-C-Alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile

Guillaume Godin, Philippe Compain, Olivier R. Martin, Kyoko Ikeda, Liang Yu, Naoki Asano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 287 KB

english, 2004

23

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors

Ping Chen, Derek Norris, Jagabandhu Das, Steven H. Spergel, John Wityak, Leslie Leith, Rulin Zhao, Bang-Chi Chen, Sidney Pitt, Suhong Pang, Ding Ren Shen, Rosemary Zhang, Henry F. De Fex, Arthur M. Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

24

Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine

Yusuo Chang, Zhengdong Wang, Robert H. Notter, Zhongyi Wang, Long Qu, Adrian L. Schwan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

25

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

Houchao Tao, Inkyu Hwang, Dale L. Boger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 257 KB

english, 2004

26

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena, Donatella Boschi, Gian Cesare Tron, Kostantin Chegaev, Loretta Lazzarato, Antonella Di Stilo, Manuela Aragno, Roberta Fruttero, Alberto Gasco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

27

Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues

Samir A. Carvalho, Edson F. da Silva, Ricardo M. Santa-Rita, Solange L. de Castro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

28

Tryptamine-based human β3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring

Kazuhiro Mizuno, Masaaki Sawa, Hiroshi Harada, Hirotaka Tateishi, Mayumi Oue, Hiroshi Tsujiuchi, Yasuji Furutani, Shiro Kato

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 280 KB

english, 2004

29

Publishers Announcement - Chairman of the Executive Board of Editors for Tetrahedron Publications

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

30

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

File:

PDF, 190 KB

2004

31

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

32

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 174 KB

english, 2004

33

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 1.08 MB

english, 2004

34

Author Index 2004

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

File:

PDF, 363 KB

2004

35

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists

Aaron Balog, Mark E. Salvati, Weifang Shan, Arvind Mathur, Leslie W. Leith, Donna D. Wei, Ricardo M. Attar, Jieping Geng, Cheryl A. Rizzo, Chihuei Wang, Stanley R. Krystek, John S. Tokarski, John T. H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 341 KB

english, 2004

36

Novel diarylsulfonylurea derivatives as potent antimitotic agents

Semi Kim, Ji Hyun Park, Sun-Young Koo, Jung In Kim, Min-Hyeung Kim, Ji Eun Kim, Kiwon Jo, Hwan Geun Choi, Sung Bae Lee, Sang-Hun Jung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

37

Alumina supported potassium permanganate: an efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions

Mohammad Abdollahi-Alibeik, Iraj Mohammadpoor-Baltork, Mohammad Ali Zolfigol

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

38

A comparative binding study of modified Bovine Immunodeficiency Virus TAR RNA against its TAT peptide

Jeffrey B.-H. Tok, Lanrong Bi, Shuying Huang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 312 KB

english, 2004

39

Synthesis, (1→3)-β-d-glucanase-binding ability and phytoalexin-elicitor activity of (R)-2,3-epoxypropyl (1→3)-β-d-pentaglucoside

Gang-Liang Huang, Xin-Ya Mei, Man-Xi Liu, Tian-Cai Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

40

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability

Elfatih Elzein, Prabha Ibrahim, Dmitry O. Koltun, Ken Rehder, Kevin D. Shenk, Timothy A. Marquart, Bob Jiang, Xiaofen Li, Reina Natero, Yuan Li, Marie Nguyen, Suresh Kerwar, Nancy Chu, Daniel Soohoo,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

41

Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters

Peter C. Meltzer, Duy-Phong Pham-Huu, Bertha K. Madras

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 259 KB

english, 2004

42

Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides

Sabrina Zimmerman, Alessio Innocenti, Angela Casini, James G. Ferry, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

43

Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

Patrizia Calí, Lars Nærum, Seema Mukhija, Anders Hjelmencrantz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 300 KB

english, 2004

44

Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA

Shawn P. Maddaford, Mina Motamed, Kevin B. Turner, Min Soo K. Choi, Jailall Ramnauth, Suman Rakhit, Robert R. Hudgins, Daniele Fabris, Philip E. Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 534 KB

english, 2004

45

Corrigendum to “Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor”[Bioorg. Med. Chem. Lett. 14 (2004) 4867]

HEATH, J, MEHROTRA, M, CHI, S, YU, J, HUTCHALEELAHA, A, HOLLENBACH, S, GIESE, N, SCARBOROUGH, R, PANDEY, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004

46

Publishers Announcement - Chairman of the Executive Board of Editors for Tetrahedron Publications

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

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