Volume 14; Issue 6

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Bioorganic & Medicinal Chemistry Letters
Volume 14; Issue 6

Bioorganic & Medicinal Chemistry Letters

Volume 14; Issue 6

1

Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides

Meagan E. Anderson, Tatyana Yakovleva, Yongbo Hu, Teruna J. Siahaan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

2

Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain

Tao Li, Dorina Saro, Mark R. Spaller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

3

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein

Hang Yin, Andrew D Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

4

Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries

Srivats Rajagopal, Roberto Meza-Romero, Indraneel Ghosh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

5

Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins

Bin Yang, Dongxiang Liu, Ziwei Huang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

6

1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative

Yiming Li, Qian Li, Manchi Sun, Guoqiang Song, Shanhao Jiang, Dayuan Zhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 152 KB

english, 2004

7

Thrombin inhibitors built on an azaphenylalanine scaffold

Anamarija Zega, Gregor Mlinšek, Tomaž Šolmajer, Alenka Trampuš-Bakija, Mojca Stegnar, Uroš Urleb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 237 KB

english, 2004

8

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

Tooru Kimura, Daisuke Shuto, Soko Kasai, Ping Liu, Koushi Hidaka, Takashi Hamada, Yoshio Hayashi, Chinatsu Hattori, Masashi Asai, Shinobu Kitazume, Takaomi C. Saido, Shoichi Ishiura, Yoshiaki Kiso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

9

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

Yingzhi Bi, Patrick Stoy, Leonard Adam, Bin He, John Krupinski, Diane Normandin, Ron Pongrac, Laurie Seliger, Andrew Watson, John E Macor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 171 KB

english, 2004

10

Synthesis and biological activity of selective azasugar-based TACE inhibitors

Takahiro Tsukida, Hideki Moriyama, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-Ichiro Nishimura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 159 KB

english, 2004

11

New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation

Shujiang Tu, Chunbao Miao, Fang Fang, Feng Youjian, Tuanjie Li, Qiya Zhuang, Xiaojing Zhang, Songlei Zhu, Daqing Shi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

12

Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures

Anne Goldbech Olsen, Otto Dahl, Peter E. Nielsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

13

A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents

Zhizhi Chen, Stephen J. Gregson, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 158 KB

english, 2004

14

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents

Zhiyan Xiao, Shiqing Han, Kenneth F. Bastow, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

15

Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2

Peter Ettmayer, Andreas Billich, Thomas Baumruker, Diana Mechtcheriakova, Heide Schmid, Peter Nussbaumer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 187 KB

english, 2004

16

Synthesis of novel 2-nitroimidazole-tethered tricyclic quinolines, bearing a second heteroatom, and their in vitro evaluation as hypoxia-selective cytotoxins and radiosensitizers

Maria V. Papadopoulou, Howard S. Rosenzweig, William D. Bloomer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

17

Peroxidase catalyzed formation of azine pigments—a convenient and sensitive method for the identification of human cells with positive myeloperoxidase reactivity

Anja Bodtke, Wolf-Diethard Pfeiffer, Norbert Ahrens, Peter Langer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 173 KB

english, 2004

18

Structure–activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines

Hirobumi Takahashi, Norikazu Ohtake, Toshihiro Sakamoto, Tomoharu Iino, Nobuhiko Kawanishi, Masayuki Nakamura, Takashi Yoshizumi, Kenji Niiyama, Satoshi Ozaki, Hiromasa Okada, Akiko Kano, Hiroyuki Tak

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 219 KB

english, 2004

19

Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480

Gianluca Sbardella, Antonello Mai, Marino Artico, Roberta Loddo, Maria Grazia Setzu, Paolo La Colla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 180 KB

english, 2004

20

2-(N-Acyl) and 2-N-acyl-N6-substituted analogues of adenosine and their affinity at the human adenosine receptors

Prakash G. Jagtap, Zhiyu Chen, Csaba Szabó, Karl-Norbert Klotz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

21

New PDMP analogues inhibit process outgrowth in an insect cell line

Jacob P. Slavish, Donna K. Friel, Lynne A. Oland, Robin Polt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

22

Synthesis of cinnamic acids and related isosteres as potent and selective αvβ3 receptor antagonists

Thomas D. Penning, Mark A. Russell, Barbara B. Chen, Helen Y. Chen, Bipin N. Desai, Stephen H. Docter, David J. Edwards, Glen J. Gesicki, Chi-Dean Liang, James W. Malecha, Stella S. Yu, V.Wayne Englem

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 236 KB

english, 2004

23

Therapeutic intervention targeting protein–protein interactions

Jean Chmielewski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 60 KB

english, 2004

24

Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituents

Jens-Uwe Peters, Silja Weber, Stéphane Kritter, Peter Weiss, Angelina Wallier, Markus Boehringer, Michael Hennig, Bernd Kuhn, Bernd-Michael Loeffler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 179 KB

english, 2004

25

Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization

Robert B. Perni, Janos Pitlik, Shawn D. Britt, John J. Court, Lawrence F. Courtney, David D. Deininger, Luc J. Farmer, Cynthia A. Gates, Scott L. Harbeson, Rhonda B. Levin, Chao Lin, Kai Lin, Young-Ch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 292 KB

english, 2004

26

Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-β

Baoqing Gong, Feng Hong, Cory Kohm, Lynn Bonham, Peter Klein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 215 KB

english, 2004

27

HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors

Gabriela Iurcu Mustata, Alessandro Brigo, James M. Briggs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 368 KB

english, 2004

28

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA–FtsZ interaction

Lee D. Jennings, Ken W. Foreman, Thomas S. Rush III, Desiree H.H. Tsao, Lidia Mosyak, Yuanhong Li, Mohani N. Sukhdeo, Weidong Ding, Elizabeth G. Dushin, Cynthia Hess Kenny, Soraya L. Moghazeh, Peter J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

29

Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands

Christopher J Arnusch, Sabine André, Paola Valentini, Martin Lensch, Roland Russwurm, Hans-Christian Siebert, Marcel J.E Fischer, Hans-Joachim Gabius, Roland J Pieters

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 223 KB

english, 2004

30

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

Helen Y. Chen, Kevin D. Dykstra, Elizabeth T. Birzin, Katalin Frisch, Wanda Chan, Yi T. Yang, Ralph T. Mosley, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

31

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

Allan Wissner, Philip R. Hamann, Ramaswamy Nilakantan, Lee M. Greenberger, Fei Ye, Timothy A. Rapuano, Frank Loganzo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

32

Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor

Christopher Tan, Lianhu Wei, F.Peter Ottensmeyer, Ira Goldfine, Betty A. Maddux, Cecil C. Yip, Robert A. Batey, Lakshmi P. Kotra

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 223 KB

english, 2004

33

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 57 KB

english, 2004

34

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 451 KB

english, 2004

35

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

File:

PDF, 56 KB

2004

36

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 109 KB

english, 2004

37

Fertilinβ peptidic liposomes inhibit fertilization by steric blockage

Samidha Konkar, Suparna Gupta, Nicole S. Sampson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 181 KB

english, 2004

38

Crucial amides for dimerization inhibitors of HIV-1 protease

Michael J. Bowman, Jean Chmielewski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 235 KB

english, 2004

39

Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase

Keith G. Watson, Rachel Cameron, Rob J. Fenton, David Gower, Stephanie Hamilton, Betty Jin, Guy Y. Krippner, Angela Luttick, Darryl McConnell, Simon J.F. MacDonald, Andy M. Mason, Van Nguyen, Simon P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 166 KB

english, 2004

40

Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A

John T Randolph, Daryl R Sauer, Fortuna Haviv, Angela M Nilius, Jonathan Greer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 151 KB

english, 2004

41

(±)-cis-(6-Ethyl-tetrahydropyran-2-yl)-formic acid: a novel substance with antinociceptive properties

L.S.M Miranda, Bruno G Marinho, Suzana G Leitão, Maria Eline Matheus, Patrı́cia D Fernandes, M.L.A.A Vasconcellos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 130 KB

english, 2004

42

Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification

Vadapalli Chandrasekhar, Pravas Deria, Venkatasubbaiah Krishnan, Arunachalampillai Athimoolam, Sanjay Singh, C. Madhavaiah, S.G. Srivatsan, Sandeep Verma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

43

Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Pierre-Yves Michellys, Jennifer D'Arrigo, Timothy A. Grese, Donald S. Karanewsky, Mark D. Leibowitz, Dale A. Mais, Christopher M. Mapes, Anne Reifel-Miller, Deepa Rungta, Marcus F. Boehm

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

44

A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor

Mickaël Montembault, Giang Vo-Thanh, Abdallah Deyine, Valérie Fargeas, Monique Villiéras, Ané Adjou, Didier Dubreuil, Didier Esquieu, Catherine Grégoire, Sandrine Opi, Jean-Marie Péloponèse, Grant Cam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

45

Synthesis of a novel nitroimidazole-spermidine derivative as a tumor-targeted hypoxia-selective cytotoxin

Maria V Papadopoulou, Howard S Rosenzweig, William D Bloomer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

46

Hypocrellin derivative with improvements of red absorption and active oxygen species generation

Shangjie Xu, Shen Chen, Manhua Zhang, Tao Shen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 130 KB

english, 2004

47

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

John Wityak, Frank W. Hobbs, Daniel S. Gardner, Joseph B. Santella III, Joseph J. Petraitis, Jung-Hui Sun, Margaret F. Favata, Andrea J. Daulerio, Kurumi Y. Horiuchi, Robert A. Copeland, Peggy A. Sche

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 203 KB

english, 2004

48

Identification of novel potent bicyclic peptide deformylase inhibitors

Valentina Molteni, Xiaohui He, Juliet Nabakka, Kunyong Yang, Andreas Kreusch, Perry Gordon, Badry Bursulaya, Ian Warner, Tanya Shin, Tanya Biorac, Neil S. Ryder, Ron Goldberg, John Doughty, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

49

Determination of the stable conformation of GABAA-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis

Dongmei Han, F.Holger Försterling, Xiaoyan Li, Jeffrey R. Deschamps, Hui Cao, James M. Cook

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

50

Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid

Yong Xu, Yimin Fang, Jie Chen, Glenn D. Prestwich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 146 KB

english, 2004

51

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression

Charles Q. Meng, X.Sharon Zheng, Liming Ni, Zhihong Ye, Jacob E. Simpson, Kimberly J. Worsencroft, Martha R. Hotema, M.David Weingarten, Jason W. Skudlarek, Joshua M. Gilmore, Lee K. Hoong, Russell R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

52

Crucial role of the peroxyketal function for antimalarial activity in the G-factor series

Fadia Najjar, Liliane Gorrichon, Michel Baltas, Henri Vial, Théodore Tzedakis, Christiane André-Barrès

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 168 KB

english, 2004

53

The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria

Gary C. Look, Charles Vacin, Tracy M. Dias, Sun Ho, Thuy H. Tran, Laurance L. Lee, Cedric Wiesner, Flora Fang, Andrea Marra, Don Westmacott, Alexander E. Hromockyj, Martin M. Murphy, John R. Schullek

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

54

Bioorganic & Medicinal Chemistry Letters Symposia-in-Print

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

55

Bioorganic & Medicinal Chemistry Letters Symposia-in-Print

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

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