Volume 15; Issue 14

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Bioorganic & Medicinal Chemistry Letters
Volume 15; Issue 14

Bioorganic & Medicinal Chemistry Letters

Volume 15; Issue 14

1

Neomycin improves cationic lipid-mediated transfection of DNA in human cells

Sara Napoli, Giuseppina M. Carbone, Carlo V. Catapano, Nick Shaw, Dev. P. Arya

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

2

Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents

Lieven Meerpoel, Jef Van Gestel, Frans Van Gerven, Filip Woestenborghs, Patrick Marichal, Vic Sipido, Gilkerson Terence, Roger Nash, David Corens, Ray D. Richards

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 326 KB

english, 2005

3

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Matthias Nettekoven, Wolfgang Guba, Werner Neidhart, Patrizio Mattei, Philippe Pflieger, Olivier Roche, Sven Taylor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 206 KB

english, 2005

4

Novel iron-specific fluorescent probes

Yongmin Ma, Wei Luo, Michel Camplo, Zudong Liu, Robert C. Hider

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

5

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

Raman K. Bakshi, Qingmei Hong, J.T. Olson, Zhixiong Ye, Iyassue K. Sebhat, David H. Weinberg, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, William J. Martin, Alison Strack, Erin McGowan, Constantin Tam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 188 KB

english, 2005

6

Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Martin W. Rowbottom, Troy D. Vickers, Brian Dyck, Junko Tamiya, Mingzhu Zhang, Liren Zhao, Jonathan Grey, David Provencal, David Schwarz, Christopher E. Heise, Monica Mistry, Andrew Fisher, Teresa Don

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 251 KB

english, 2005

7

Structure–activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor

Joseph A. Tran, Joseph Pontillo, Melissa Arellano, Beth A. Fleck, Fabio C. Tucci, Dragan Marinkovic, Caroline W. Chen, John Saunders, Alan C. Foster, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

8

4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions?

R. Krishna Kumar, Vasulinga T. Ravikumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 242 KB

english, 2005

9

(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors

Mark J. Bamford, Nicholas Bailey, Susannah Davies, David K. Dean, Leann Francis, Terence A. Panchal, Christopher A. Parr, Sanjeet Sehmi, Jon G. Steadman, Andrew K. Takle, James T. Townsend, David M. W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

10

(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

Mark J. Bamford, Michael J. Alberti, Nicholas Bailey, Susannah Davies, David K. Dean, Alessandra Gaiba, Stephen Garland, John D. Harling, David K. Jung, Terence A. Panchal, Christopher A. Parr, Jon G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 183 KB

english, 2005

11

Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation

Hwa-Jin Chung, Ok-Jai Jung, Mi Jin Chae, Sung-Yu Hong, Kwang-Hoe Chung, Sang Kook Lee, Chung-Kyu Ryu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 506 KB

english, 2005

12

Identification of aminopiperidine benzamides as MCHr1 antagonists

Anil Vasudevan, Mary K. Verzal, Derek Wodka, Andrew J. Souers, Christopher Blackburn, Jennifer Lee Che, Sujen Lai, Sevan Brodjian, Doug H. Falls, Brian D. Dayton, Elizabeth Govek, Tom Daniels, Brad Ge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 244 KB

english, 2005

13

Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors

Manish Dixit, Brajendra K. Tripathi, Arvind K. Srivastava, Atul Goel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 157 KB

english, 2005

14

Solid state photochemistry of 1,4-dihydropyridines

Hamid R. Memarian, Arsalan Mirjafari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

15

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

Denis Riendeau, Renee Aspiotis, Diane Ethier, Yves Gareau, Erich L. Grimm, Jocelyne Guay, Sébastien Guiral, Hélène Juteau, Joseph A. Mancini, Nathalie Méthot, Joel Rubin, Richard W. Friesen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

16

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

Hiroo Koyama, Julia K. Boueres, Daniel J. Miller, Joel P. Berger, Karen L. MacNaul, Pei-ran Wang, Marc C. Ippolito, Samuel D. Wright, Arun K. Agrawal, David E. Moller, Soumya P. Sahoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 281 KB

english, 2005

17

An improved synthesis of 5′-fluoro-5′-deoxyadenosines

Trent D. Ashton, Peter J. Scammells

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 122 KB

english, 2005

18

A novel [99mTcN]2+ complex of metronidazole xanthate as a potential agent for targeting hypoxia

Madhava B. Mallia, Anupam Mathur, Suresh Subramanian, Sharmila Banerjee, H.D. Sarma, Meera Venkatesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 165 KB

english, 2005

19

6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators

Ashoke Sharon, Ramendra Pratap, Rit Vatsyayan, Prakas R. Maulik, Uma Roy, Atul Goel, Vishnu Ji Ram

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 413 KB

english, 2005

20

Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Sung Eun Kim, Su Yeon Kim, Sunghoon Kim, Taehee Kang, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 325 KB

english, 2005

21

Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Eduarda M.P. Silva, Francesca Giuntini, Maria A.F. Faustino, João P.C. Tomé, Maria G.P.M.S. Neves, Augusto C. Tomé, Artur M.S. Silva, Maria G. Santana-Marques, António J. Ferrer-Correia, José A.S. Cav

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

22

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, Martin G. Rowlands, Katherine J. Boxall, Swee Y. Sharp, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, G. Wynne Aherne, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 590 KB

english, 2005

23

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3

Bader A. Salameh, Hakon Leffler, Ulf J. Nilsson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

24

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 440 KB

english, 2005

25

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 681 KB

english, 2005

26

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

27

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 75 KB

english, 2005

28

RGD mounted on an L-proline scaffold

Eric Enholm, Ashwin Bharadwaj

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

29

Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents

Vishnu K. Tandon, Dharmendra B. Yadav, Ravindra V. Singh, Meenu Vaish, Ashok K. Chaturvedi, Praveen K. Shukla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

30

Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity

Michael J. Stocks, Simon Barber, Rhonan Ford, Frederic Leroux, Steve St-Gallay, Simon Teague, Yafeng Xue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 1.02 MB

english, 2005

31

Potential new antitumor agents from an innovative combination of camphorato, a ramification of traditional Chinese medicine, with a platinum moiety

Lianhong Wang, Shaohua Gou, Yongjiang Chen, Yun Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

32

Active site binding modes of curcumin in HIV-1 protease and integrase

Opa Vajragupta, Preecha Boonchoong, Garrett M. Morris, Arthur J. Olson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 645 KB

english, 2005

33

Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide

Jai Woong Seo, Ekaruth Srisook, Hyo Jin Son, Onyou Hwang, Young-Nam Cha, Dae Yoon Chi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

34

Rhodanine derivatives as inhibitors of JSP-1

Neil S. Cutshall, Christine O’Day, Marina Prezhdo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 196 KB

english, 2005

35

Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents

Masao Yoshida, Ichiro Hayakawa, Noriyuki Hayashi, Toshinori Agatsuma, Youko Oda, Fumie Tanzawa, Shiho Iwasaki, Kumiko Koyama, Hidehiko Furukawa, Shinichi Kurakata, Yuichi Sugano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 259 KB

english, 2005

36

Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13

Mark C. Noe, Vijayalakshmi Natarajan, Sheri L. Snow, Lilli A. Wolf-Gouveia, Peter G. Mitchell, Lori Lopresti-Morrow, Lisa M. Reeves, Sue A. Yocum, Ivan Otterness, Marcia A. Bliven, Thomas J. Carty, Jo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 203 KB

english, 2005