Volume 15; Issue 22

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Bioorganic & Medicinal Chemistry Letters
Volume 15; Issue 22

Bioorganic & Medicinal Chemistry Letters

Volume 15; Issue 22

1

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

Britt-Marie Swahn, Fernando Huerta, Elisabet Kallin, Jonas Malmström, Tatjana Weigelt, Jenny Viklund, Patrick Womack, Yafeng Xue, Liselotte Öhberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

2

Proteins QSAR with Markov average electrostatic potentials

Humberto González-Díaz, Eugenio Uriarte

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 199 KB

english, 2005

3

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

Lida R. Tehrani, Nicholas D. Smith, Dehua Huang, Steve F. Poon, Jeffrey R. Roppe, Thomas Jon Seiders, Deborah F. Chapman, Janice Chung, Merryl Cramer, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

4

Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases

Michael E. Jung, Jeremy J. Clemens, Nuttee Suree, Chu Kong Liew, Rosemarie Pilpa, Dean O. Campbell, Robert T. Clubb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 157 KB

english, 2005

5

Synthesis of desthio prenylcysteine analogs: Sulfur is important for biological activity

Brian S. Henriksen, Jessica L. Anderson, Christine A. Hrycyna, Richard A. Gibbs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

6

Structure–activity relationship study of novel necroptosis inhibitors

Xin Teng, Alexei Degterev, Prakash Jagtap, Xuechao Xing, Sungwoon Choi, Régine Denu, Junying Yuan, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 153 KB

english, 2005

7

Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy- and ribo purinenucleosides using active esters

Snehlata Tripathi, Krishna Misra, Yogesh S. Sanghvi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 102 KB

english, 2005

8

Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation

Frédéric Maurel, Françoise Debart, Florine Cavelier, Alain R. Thierry, Bernard Lebleu, Jean-Jacques Vasseur, Eric Vivès

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

9

Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity

Jun F. Liang, Victor C. Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 175 KB

english, 2005

10

Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid for colon delivery

Massimo Curini, Francesco Epifano, Salvatore Genovese

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 110 KB

english, 2005

11

Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis

Fabrice Bailly, Clémence Queffelec, Gladys Mbemba, Jean-François Mouscadet, Philippe Cotelle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 125 KB

english, 2005

12

Synthesis and SAR of highly selective MMP-13 inhibitors

Jianchang Li, Thomas S. Rush III, Wei Li, Dianne DeVincentis, Xuemei Du, Yonghan Hu, Jennifer R. Thomason, Jason S. Xiang, Jerauld S. Skotnicki, Steve Tam, Kristina M. Cunningham, Priya S. Chockalinga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

13

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

James F. Dropinski, Taro Akiyama, Monica Einstein, Bahanu Habulihaz, Tom Doebber, Joel P. Berger, Peter T. Meinke, Guo Q. Shi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 184 KB

english, 2005

14

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Alexander Greenfield, Cristina Grosanu, John Dunlop, Beal McIlvain, Tikva Carrick, Brian Jow, Qiang Lu, Dianne Kowal, John Williams, John Butera

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 149 KB

english, 2005

15

Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain

Guofeng Ye, Marina Ayrapetov, Nguyen-Hai Nam, Gongqin Sun, Keykavous Parang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 247 KB

english, 2005

16

Pyrazolopyridinones as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, Richard Lewis, Michael G.N. Russell, Alison Smith, Keith Wafford, Ruth M. McKernan, Leslie J. Street, José L. Castro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

17

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

Tao Zhou, Zu Dong Liu, Hendrik Neubert, Xiao Le Kong, Yong Min Ma, Robert C. Hider

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

18

Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor

Gilles C. Bignan, Kathleen Battista, Peter J. Connolly, Michael J. Orsini, Jingchun Liu, Steven A. Middleton, Allen B. Reitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 127 KB

english, 2005

19

Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine

Viney Lather, Anil K. Madan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 137 KB

english, 2005

20

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Xin-Jie Chu, David Bartkovitz, Waleed Danho, Joseph Swistok, Adrian Wai-Hing Cheung, Grazyna Kurylko, Karen Rowan, Mitch Yeon, Lucia Franco, Lida Qi, Li Chen, Keith Yagaloff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

21

Structure-based design of 7-carbamate analogs of geldanamycin

Giulio Rastelli, Zong-Qiang Tian, Zhan Wang, David Myles, Yaoquan Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

22

Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye

Huahua Yu, Xiguang Liu, Xiangli Dong, Cuiping Li, Ronge Xing, Song Liu, Pengcheng Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 107 KB

english, 2005

23

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol

Qiong Xie, Xiaolin Wang, Xinghai Wang, Zhiqiang Jiang, Zhuibai Qiu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 162 KB

english, 2005

24

Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents

Anu Agarwal, Kumkum Srivastava, S.K. Puri, S. Sinha, Prem M.S. Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

25

Bis(indole) alkaloids as sortase A inhibitors from the sponge Spongosorites sp.

Ki-Bong Oh, Woongchon Mar, Sanghee Kim, Ji-Yun Kim, Mi-Na Oh, Jae-Gyu Kim, Daehyun Shin, Chung J. Sim, Jongheon Shin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

26

A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor

Vinod R. Hegde, Haiyan Pu, Mahesh Patel, Adrian Jachens, Vincent P. Gullo, Tze-Ming Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

27

Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents

Sanjay Babu Katiyar, Kumkum Srivastava, S.K. Puri, Prem M.S. Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

28

Synthesis and in vitro cytotoxicity of novel hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes

Haibin Zhu, Kai Cui, Lianhong Wang, Shaohua Gou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

29

Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases

Xiaoan Wen, Hongbin Sun, Jun Liu, Guanzhong Wu, Luyong Zhang, Xiaoming Wu, Peizhou Ni

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

30

Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

George P. Lahm, Thomas P. Selby, John H. Freudenberger, Thomas M. Stevenson, Brian J. Myers, Gilles Seburyamo, Ben K. Smith, Lindsey Flexner, Christopher E. Clark, Daniel Cordova

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 175 KB

english, 2005

31

Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines

Y. Rajendra Prasad, A. Lakshmana Rao, L. Prasoona, K. Murali, P. Ravi Kumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 132 KB

english, 2005

32

Editorial Board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 320 KB

english, 2005

33

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 547 KB

english, 2005

34

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

File:

PDF, 189 KB

2005

35

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 29 KB

english, 2005

36

Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells

Ioannis K. Kostakis, Roxane Tenta, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Harris Pratsinis, Dimitris Kletsas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

37

New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities

Valérie Jullian, Colin Bonduelle, Alexis Valentin, Lucia Acebey, Anne-Gaëlle Duigou, Marie-Francoise Prévost, Michel Sauvain

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 148 KB

english, 2005

38

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists

Caroline J. Goodacre, Steven M. Bromidge, David Clapham, Frank D. King, Peter J. Lovell, Mike Allen, Lorraine P. Campbell, Vicky Holland, Graham J. Riley, Kathryn R. Starr, Brenda K. Trail, Martyn D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

39

(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators

Aranapakam M. Venkatesan, George T. Grosu, Amedeo A. Failli, Peter S. Chan, Joseph Coupet, Trina Saunders, Hussain Mazandarani, Xun Ru

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

40

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides

John G. Cumming, Anne E. Cooper, Ken Grime, Chris J. Logan, Sharon McLaughlin, John Oldfield, John S. Shaw, Howard Tucker, Jon Winter, David Whittaker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

41

Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1

Hong Liu, David C. Tully, Robert Epple, Badry Bursulaya, Jun Li, Jennifer L. Harris, Jennifer A. Williams, Ross Russo, Christine Tumanut, Michael J. Roberts, Phil B. Alper, Yun He, Donald S. Karanewsk

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 292 KB

english, 2005

42

Privileged structure based ligands for melanocortin receptors—Substituted benzylic piperazine derivatives

Matthew J. Fisher, Ryan T. Backer, Iván Collado, Óscar de Frutos, Saba Husain, Hansen M. Hsiung, Steve L. Kuklish, Ana I. Mateo, Jeffrey T. Mullaney, Paul L. Ornstein, Cristina García Paredes, Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 137 KB

english, 2005

43

Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid

Kazunori Yamamoto, Naoki Watanabe, Hiroko Matsuda, Keiichiro Oohara, Tomoyuki Araya, Masaru Hashimoto, Kazuo Miyairi, Isao Okazaki, Minoru Saito, Tetsuya Shimizu, Hiroaki Kato, Toshikatsu Okuno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 221 KB

english, 2005

44

The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

Xiaojing Wang, Michael T. Migawa, Kristin A. Sannes-Lowery, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

45

The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines

Gennady B. Lapa, Gary D. Byrd, Alla A. Lapa, Evgeny A. Budygin, Steven R. Childers, Sara R. Jones, Jill J. Harp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

46

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Jotham W. Coe, Paige R. Brooks, Michael C. Wirtz, Crystal G. Bashore, Krista E. Bianco, Michael G. Vetelino, Eric P. Arnold, Lorraine A. Lebel, Carol B. Fox, F. David Tingley III, David W. Schulz, Tho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 224 KB

english, 2005

47

Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives

Li-Ming Zhao, Hai-Shan Jin, Liang-Peng Sun, Hu-Ri Piao, Zhe-Shan Quan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

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