Volume 15; Issue 6

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Bioorganic & Medicinal Chemistry Letters
Volume 15; Issue 6

Bioorganic & Medicinal Chemistry Letters

Volume 15; Issue 6

1

Synthesis and fluorescence studies of thiazole orange tethered onto oligonucleotide: development of a self-contained DNA biosensor on a fiber optic surface

Xiaofeng Wang, Ulrich J. Krull

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

2

1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands

Mase Lee, Jagadeesh B. Rangisetty, Manik R. Pullagurla, Małgorzata Dukat, Vince Setola, Bryan L. Roth, Richard A. Glennon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

3

From a total synthesis of cepabactin and its 3:1 ferric complex to the isolation of a 1:1:1 mixed complex between iron (III), cepabactin and pyochelin

Cédric Klumpp, Alain Burger, Gaëtan L. Mislin, Mohamed A. Abdallah

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

4

A chromism-based assay (CHROBA) technique for in situ detection of protein kinase activity

Kin-ya Tomizaki, Xu Jie, Hisakazu Mihara

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 210 KB

english, 2005

5

Design, synthesis and structure–activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands

Min Ji, Jianyong Chen, Ke Ding, Xihan Wu, Judith Varady, Beth Levant, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

6

Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification

Robin D. Clark, Alam Jahangir, Muzaffar Alam, Cynthia Rocha, Lin Lin, Bodil Bjorner, Khanh Nguyen, Carole Grady, Timothy J. Williams, George Stepan, Hai Ming Tang, Anthony P.D.W. Ford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 114 KB

english, 2005

7

Synthesis and characterization of a carboranyl-tetrabenzoporphyrin

Owendi Ongayi, Vijay Gottumukkala, Frank R. Fronczek, M. Graça H. Vicente

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 239 KB

english, 2005

8

Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)

Mark J. Mulvihill, Julie L.C. Kan, Patricia Beck, Mark Bittner, Cara Cesario, Andrew Cooke, David M. Keane, Anthony I. Nigro, Christy Nillson, Vanessa Smith, Mary Srebernak, Feng-Lei Sun, Michael Vrkl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

9

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors

Darin J. Gustin, Clark A. Sehon, Jianmei Wei, Hui Cai, Steven P. Meduna, Haripada Khatuya, Siquan Sun, Yin Gu, Wen Jiang, Robin L. Thurmond, Lars Karlsson, James P. Edwards

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 135 KB

english, 2005

10

QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices

Humberto González-Díaz, Maykel Cruz-Monteagudo, Dolores Viña, Lourdes Santana, Eugenio Uriarte, Erik De Clercq

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

11

Combinatorial approaches towards the discovery of new tryptase inhibitors

Montserrat del Fresno, Dolors Fernández-Forner, Montserrat Miralpeix, Victor Segarra, Hamish Ryder, Miriam Royo, Fernando Albericio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 165 KB

english, 2005

12

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates

Jean-Yves Winum, Alessio Innocenti, Valerie Gagnard, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

13

Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors

Guy Falardeau, Hugo Lachance, Annie St-Pierre, Constantin G. Yannopoulos, Marc Drouin, Jean Bédard, Laval Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

14

Nonpeptide αvβ3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics

Amy E. Zartman, Le T. Duong, Carmen Fernandez-Metzler, George D. Hartman, Chih-Tai Leu, Thomayant Prueksaritanont, Gideon A. Rodan, Sevgi B. Rodan, Mark E. Duggan, Robert S. Meissner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

15

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Arie Zask, Joshua Kaplan, XueMei Du, Gloria MacEwan, Vincent Sandanayaka, Nancy Eudy, Jeremy Levin, Guixian Jin, Jun Xu, Terri Cummons, Dauphine Barone, Semiramis Ayral-Kaloustian, Jerauld Skotnicki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

16

3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

Jonathan R. Dimmock, Umashankar Das, H. Inci Gul, Masami Kawase, Hiroshi Sakagami, Zoltán Baráth, Imre Ocsovsky, Joseph Molnár

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

17

Erratum to “Crystallographic determination of stereochemistry of biologically active 2″,3″-dibromo-7-epi-10-deacetylcaphalomannine”: [Bioorg. Med. Chem. Lett. 15 (2005) 839]

Yi Jiang, Hai-Xia Lin, Jian-Min Chen, Min-Qin Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 56 KB

english, 2005

18

Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs)

William D. Schmitz, Derek J. Denhart, Allison B. Brenner, Jonathan L. Ditta, Ronald J. Mattson, Gail K. Mattson, Thaddeus F. Molski, John E. Macor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 104 KB

english, 2005

19

iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism

Seongjin Kim, William S. Powell, John A. Lawson, Sheila H. Jacobo, Domenico Pratico, Garret A. FitzGerald, Kirk Maxey, Joshua Rokach

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 159 KB

english, 2005

20

Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Wolfgang Guba, Werner Neidhart, Matthias Nettekoven

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 181 KB

english, 2005

21

Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin

Konstantina C. Fylaktakidou, Jean-Marie Lehn, Ruth Greferath, Claude Nicolau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 196 KB

english, 2005

22

Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

Cledir Santos, Maria Luísa Mateus, Ana Paula dos Santos, Rui Moreira, Eliandre de Oliveira, Paula Gomes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 129 KB

english, 2005

23

The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide

Joanne T. Blanchfield, Rebecca A. Lew, A. Ian Smith, Istvan Toth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 140 KB

english, 2005

24

Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

John K. Pratt, Pamela Donner, Keith F. McDaniel, Clarence J. Maring, Warren M. Kati, Hongmei Mo, Tim Middleton, Yaya Liu, Teresa Ng, Qinghua Xie, Rong Zhang, Debra Montgomery, Akhteruzzaman Molla, Dal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

25

Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide

James M. MacDougall, Xiao-Dong Zhang, Willma E. Polgar, Taline V. Khroyan, Lawrence Toll, John R. Cashman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

26

Synthesis of isonicotinic acid N′-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents

Neelima Sinha, Sanjay Jain, Ajay Tilekar, Ram Shankar Upadhayaya, Nawal Kishore, Gour Hari Jana, Sudershan K. Arora

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

27

Design, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2

Shinya Usui, Takayoshi Suzuki, Yoshifumi Hattori, Kazuma Etoh, Hiroki Fujieda, Makoto Nishizuka, Masayoshi Imagawa, Hidehiko Nakagawa, Kohfuku Kohda, Naoki Miyata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 195 KB

english, 2005

28

Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies

Nicolas Pietrancosta, Flavio Maina, Rosanna Dono, Anice Moumen, Cédrik Garino, Younes Laras, Stéphane Burlet, Gilles Quéléver, Jean-Louis Kraus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

29

Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

George Burton, Thomas W. Ku, Thomas J. Carr, Terry Kiesow, Robert T. Sarisky, Juili Lin-Goerke, Audrey Baker, David L. Earnshaw, Glenn A. Hofmann, Richard M. Keenan, Dashyant Dhanak

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 114 KB

english, 2005

30

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 171 KB

english, 2005

31

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 553 KB

english, 2005

32

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

File:

PDF, 190 KB

2005

33

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 71 KB

english, 2005

34

Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists

Michael J. Robarge, David C. Bom, L. Nathan Tumey, Norbert Varga, Elizabeth Gleason, Daniel Silver, Jianping Song, Steven M. Murphy, George Ekema, Chris Doucette, Doug Hanniford, Marc Palmer, Gary Paw

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 129 KB

english, 2005

35

Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor

Ana Carolina Barrios Sosa, Diane H. Boschelli, Biqi Wu, Yan Wang, Jennifer M. Golas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

36

A two-state homology model of the hERG K+ channel: application to ligand binding

Ramkumar Rajamani, Brett A. Tounge, Jian Li, Charles H. Reynolds

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 238 KB

english, 2005

37

Novel β-(imidazol-4-yl)-β-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I

Ashis K. Saha, David W. End

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

38

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs

Qiang Tan, Timothy A. Blizzard, Jerry D. Morgan II, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Sudha Warrier, Joel Yudkovitz, Hilary A. Wilkinson,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 264 KB

english, 2005

39

Corrigendum to “Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists”: [Bioorg. Med. Chem. Lett. 15 (2005) 645]

Laura C. Meurer, Paul E. Finke, Sander G. Mills, Thomas F. Walsh, Richard B. Toupence, John S. Debenham, Mark T. Goulet, Junying Wang, Xinchun Tong, Tung M. Fong, Julie Lao, Marie-Therese Schaeffer, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 54 KB

english, 2005

40

3-(2,5-Dihydro-1H-pyrrol-2-ylmethoxy)pyridines: synthesis and analgesic activity

Ivan L. Baraznenok, Emma Jonsson, Alf Claesson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 122 KB

english, 2005

41

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

Christopher Fotsch, Nianhe Han, Premilla Arasasingham, Yunxin Bo, Michelle Carmouche, Ning Chen, James Davis, Martin H. Goldberg, Clarence Hale, Feng-Yin Hsieh, Michael G. Kelly, Qingyian Liu, Mark H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

42

Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation

Yuan Zhang, Jian-xin Li, Jianwei Zhao, Shao-zhong Wang, Yi Pan, Ken Tanaka, Shigetoshi Kadota

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 164 KB

english, 2005

43

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

Ariamala Gopalsamy, Hui Yang, John W. Ellingboe, Hwei-Ru Tsou, Nan Zhang, Erick Honores, Dennis Powell, Miriam Miranda, John P. McGinnis, Sridhar K. Rabindran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 122 KB

english, 2005

44

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

David R. Anderson, Shridhar Hegde, Emily Reinhard, Leslie Gomez, William F. Vernier, Len Lee, Shuang Liu, Aruna Sambandam, Patricia A. Snider, Liaqat Masih

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

45

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

Anthony B. Pinkerton, Rowena V. Cube, John H. Hutchinson, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Hervé Schaffhauser, Dana E. Rodriguez, Una C. Campbell, Lorrie P. Daggett, Jean-Michel Vern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

46

3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

Irina Shcherbakova, Manuel F. Balandrin, John Fox, Anjan Ghatak, William L. Heaton, Rebecca L. Conklin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

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