Volume 16; Issue 22

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Bioorganic & Medicinal Chemistry Letters
Volume 16; Issue 22

Bioorganic & Medicinal Chemistry Letters

Volume 16; Issue 22

1

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARγ ligands (I)

Xiaochun Dong, Zhenshan Zhang, Ren Wen, Jianhua Shen, Xu Shen, Hualiang Jiang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 743 KB

english, 2006

2

Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: Synthesis and biological evaluation as potential antibacterial and antifungal agents

Vishnu K. Tandon, Hardesh K. Maurya, Dharmendra B. Yadav, Ashutosh Tripathi, Manish Kumar, Praveen K. Shukla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

3

Synthesis and free radical scavenging activity of a novel metabolite from the fungus Colletotrichum gloeosporioides

Marienca Femenía-Ríos, Carlos M. García-Pajón, Rosario Hernández-Galán, Antonio J. Macías-Sánchez, Isidro G. Collado

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

4

Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors

Sung Hee Hwang, Christophe Morisseau, Zung Do, Bruce D. Hammock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

5

The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors

Kevin J. Moriarty, Holly K. Koblish, Thomas Garrabrant, Jahanvi Maisuria, Ehab Khalil, Farah Ali, Ioanna P. Petrounia, Carl S. Crysler, Anna C. Maroney, Dana L. Johnson, Robert A. Galemmo Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 360 KB

english, 2006

6

A novel 99mTc-labeled testosterone derivative as a potential agent for targeting androgen receptors

Tapas Das, Sharmila Banerjee, Grace Samuel, Ketaki Bapat, Suresh Subramanian, Maroor R.A. Pillai, Meera Venkatesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 172 KB

english, 2006

7

N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II

Jason M. Elliott, Robert W. Carling, Gary G. Chicchi, James Crawforth, Peter H. Hutson, A. Brian Jones, Sarah Kelly, Rose Marwood, Georgina Meneses-Lorente, Elena Mezzogori, Fraser Murray, Michael Rig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

8

N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists

Jason M. Elliott, Robert W. Carling, Mark Chambers, Gary G. Chicchi, Peter H. Hutson, A. Brian Jones, Angus MacLeod, Rose Marwood, Georgina Meneses-Lorente, Elena Mezzogori, Fraser Murray, Michael Rig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

9

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Gang Liu, Hongyu Zhao, Bo Liu, Zhili Xin, Mei Liu, Christi Kosogof, Bruce G. Szczepankiewicz, Sanyi Wang, Jill E. Clampit, Rebecca J. Gum, Deanna L. Haasch, James M. Trevillyan, Hing L. Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 294 KB

english, 2006

10

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

Shaei Huang, Robert M. Garbaccio, Mark E. Fraley, Justin Steen, Constantine Kreatsoulas, George Hartman, Steve Stirdivant, Bob Drakas, Keith Rickert, Eileen Walsh, Kelly Hamilton, Carolyn A. Buser, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

11

Potent antagonists of the Kv1.5 potassium channel: Synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides

Kausik K. Nanda, M. Brad Nolt, Matthew J. Cato, Stefanie A. Kane, Laszlo Kiss, Robert H. Spencer, Jixin Wang, Joseph J. Lynch, Christopher P. Regan, Gary L. Stump, Bing Li, Rebecca White, Suzie Yeh, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 213 KB

english, 2006

12

Synthesis and structure–activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a

Yue H. Li, Frank T. Coppo, Karen A. Evans, Todd L. Graybill, Mehul Patel, Jennifer Gale, Hu Li, Francis Tavares, Stephen A. Thomson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 148 KB

english, 2006

13

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers

Shengde Wu, Andrew Fluxe, John M. Janusz, James B. Sheffer, Greg Browning, Benjamin Blass, Keith Cobum, Richard Hedges, Michael Murawsky, Bin Fang, Gina M. Fadayel, Michelle Hare, Laurent Djandjighian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

14

Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers

Andrew Fluxe, Shengde Wu, James B. Sheffer, John M. Janusz, Michael Murawsky, Gina M. Fadayel, Bin Fang, Michelle Hare, Laurent Djandjighian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 130 KB

english, 2006

15

Exploring a possible way to synthesize novel better antioxidants based on vitamin E: A DFT study

Weijun Chen, Jirong Song, Ping Guo, Wei Cao, Jiang Bian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 204 KB

english, 2006

16

A novel oxazine ring closure reaction affording (Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes and their anti-osteoclastic bone resorption activity

Yuko Ando, Kumiko Ando, Mami Yamaguchi, Jun-ichi Kunitomo, Masao Koida, Ryo Fukuyama, Hiromichi Nakamuta, Masayuki Yamashita, Shunsaku Ohta, Yoshitaka Ohishi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 301 KB

english, 2006

17

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

Lawrence A. Reiter, Kevin D. Freeman-Cook, Christopher S. Jones, Gary J. Martinelli, Amy S. Antipas, Martin A. Berliner, Kaushik Datta, James T. Downs, James D. Eskra, Michael D. Forman, Elaine M. Gre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 208 KB

english, 2006

18

6-Hydroxy- and 6-methoxy-β-carbolines as acetyl- and butyrylcholinesterase inhibitors

Yvonne Schott, Michael Decker, Hans Rommelspacher, Jochen Lehmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

19

Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors

Renata Kolanos, Małgorzata Dukat, Bryan L. Roth, Richard A. Glennon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

20

Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening

Mutasem O. Taha, Amal G. Al-Bakri, Waleed A. Zalloum

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 896 KB

english, 2006

21

Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution

Ange Polidori, Marc Presset, Florence Lebaupain, Bruno Ameduri, Jean-Luc Popot, Cécile Breyton, Bernard Pucci

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 205 KB

english, 2006

22

Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein

Jianyong Chen, Zaneta Nikolovska-Coleska, Guoping Wang, Su Qiu, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

23

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype

Michael A. Walker, Timothy Johnson, Zhuping Ma, Yunhui Zhang, Jacques Banville, Roger Remillard, Serge Plamondon, Annapurna Pendri, Henry Wong, Daniel Smith, Albert Torri, Himadri Samanta, Zeyu Lin, C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 176 KB

english, 2006

24

Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents

A. Mereu, E. Moriggi, M. Napoletano, C. Regazzoni, S. Manfredini, T.P. Mercurio, F. Pellacini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 172 KB

english, 2006

25

Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: Function of alkyl chain length on opioid activity

Kimitaka Shiotani, Tingyou Li, Anna Miyazaki, Yuko Tsuda, Sharon D. Bryant, Akihiro Ambo, Yusuke Sasaki, Lawrence H. Lazarus, Yoshio Okada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

26

Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes

Makoto Sasaki, Koichi Tsubone, Muneo Shoji, Masato Oikawa, Keiko Shimamoto, Ryuichi Sakai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 253 KB

english, 2006

27

Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin

Fabio Bellina, Silvia Cauteruccio, Susanna Monti, Renzo Rossi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 607 KB

english, 2006

28

Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers

Mingzhang Gao, Min Wang, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Qi-Huang Zheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 157 KB

english, 2006

29

New rifabutin analogs: Synthesis and biological activity against Mycobacterium tuberculosis

José Barluenga, Fernando Aznar, Ana-Belén García, María-Paz Cabal, Juan J. Palacios, María-Angela Menéndez

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 173 KB

english, 2006

30

Identification of novel inhibitors of UDP-Glc 4′-epimerase, a validated drug target for african sleeping sickness

Michael D. Urbaniak, Jioji N. Tabudravu, Aichi Msaki, Kathy Mansfield Matera, Ruth Brenk, Marcel Jaspars, Michael A.J. Ferguson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 225 KB

english, 2006

31

Odorless benzenethiols in synthesis of thioglycosides and its application for glycosylation reactions

Tetsuya Kajimoto, Yuichi Ishioka, Takahiro Katoh, Manabu Node

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

32

A protein kinase signal-responsive gene carrier modified RGD peptide

Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong-Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 337 KB

english, 2006

33

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 732 KB

english, 2006

34

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 787 KB

english, 2006

35

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 31 KB

english, 2006

36

Three-dimensional quantitative structure–activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors

Abdul Rajjak Shaikh, Mohamed Ismael, Carlos A. Del Carpio, Hideyuki Tsuboi, Michihisa Koyama, Akira Endou, Momoji Kubo, Ewa Broclawik, Akira Miyamoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

37

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Shunqi Yan, Todd Appleby, Gary Larson, Jim Z. Wu, Robert Hamatake, Zhi Hong, Nanhua Yao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 484 KB

english, 2006

38

4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents

Yi Jin, Zu-Yu Zhou, Wei Tian, Qiang Yu, Ya-Qiu Long

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 456 KB

english, 2006

39

Discovery of small molecule inhibitors of integrin αvβ3 through structure-based virtual screening

Yuan Zhou, Hui Peng, Qing Ji, Jing Qi, Zhenping Zhu, Chunzheng Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 495 KB

english, 2006

40

Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus

Boon-ek Yingyongnarongkul, Nuttapon Apiratikul, Nuntana Aroonrerk, Apichart Suksamrarn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 213 KB

english, 2006

41

Effects of α-substitutions on structure and biological activity of anticancer chalcones

Nicholas J. Lawrence, Richard P. Patterson, Li-Ling Ooi, Darren Cook, Sylvie Ducki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 235 KB

english, 2006

42

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

Barrie Wilkinson, Matthew A. Gregory, Steven J. Moss, Isabelle Carletti, Rose M. Sheridan, Andrew Kaja, Michael Ward, Carlos Olano, Carmen Mendez, José A. Salas, Peter F. Leadlay, Rob vanGinckel, Ming

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

43

p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design

Swaminathan R. Natarajan, Stephen T. Heller, Kiyean Nam, Suresh B. Singh, Giovanna Scapin, Sangita Patel, James E. Thompson, Catherine E. Fitzgerald, Stephen J. O’Keefe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 320 KB

english, 2006

44

SER-HIS-ASP catalytic triad in model non-aqueous solvent environment: A computational study

Justin Kai-Chi Lau, Yuen-Kit Cheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 618 KB

english, 2006

45

Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators

Xuqing Zhang, George F. Allan, Tifanie Sbriscia, Olivia Linton, Scott G. Lundeen, Zhihua Sui

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 134 KB

english, 2006

46

Arylsulfonamides: A study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors

Stefan Senger, Máire A. Convery, Chuen Chan, Nigel S. Watson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 285 KB

english, 2006

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