Volume 23; Issue 18

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Bioorganic & Medicinal Chemistry Letters
Volume 23; Issue 18

Bioorganic & Medicinal Chemistry Letters

Volume 23; Issue 18

1

Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility

Bollini, Mariela, Cisneros, José A., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 662 KB

english, 2013

2

Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility

Bollini, Mariela, Frey, Kathleen M., Cisneros, José A., Spasov, Krasimir A., Das, Kalyan, Bauman, Joseph D., Arnold, Eddy, Anderson, Karen S., Jorgensen, William L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 824 KB

english, 2013

3

Synthesis, cytotoxicity and DNA-binding properties of Pd(II), Cu(II) and Zn(II) complexes with 4′-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2,2′:6′,2″-terpyridine

Chu, Wenhao, Wang, Yuechai, Liu, Siyuan, Yang, Xueyun, Wang, Shuxiang, Li, Shenghui, Zhou, Guoqiang, Qin, Xinying, Zhou, Chuanqi, Zhang, Jinchao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 965 KB

english, 2013

4

Synthesis and SAR studies of marine natural products ma’edamines A, B and their analogues

Saha, Sanjay, Reddy, Ch. Venkata Ramana, Xu, Shili, Sankar, Saranya, Neamati, Nouri, Patro, Balaram

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 559 KB

english, 2013

5

Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors

Glunz, Peter W., Zhang, Xiaojun, Zou, Yan, Delucca, Indawati, Nirschl, Alexandra H., Cheng, Xuhong, Weigelt, Carolyn A., Cheney, Daniel L., Wei, Anzhi, Anumula, Rushith, Luettgen, Joseph M., Rendina,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

6

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 414 KB

english, 2013

7

Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles

Fioravanti, Rossella, Desideri, Nicoletta, Biava, Mariangela, Proietti Monaco, Luca, Grammatica, Laura, Yáñez, Matilde

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 255 KB

english, 2013

8

Syntheses and antitumor activities of N′1,N′3-dialkyl-N′1,N′3-di-(alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol

Chen, Shoujun, Sun, Lijun, Koya, Keizo, Tatsuta, Noriaki, Xia, Zhiqiang, Korbut, Timothy, Du, Zhenjian, Wu, Jim, Liang, Guiqing, Jiang, Jun, Ono, Mitsunori, Zhou, Dan, Sonderfan, Andrew

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

9

Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents

Agarwal, Sameer, Schroeder, Cornelia, Schlechtingen, Georg, Braxmeier, Tobias, Jennings, Gary, Knölker, Hans-Joachim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

10

Modulation of NMDA receptor function as a treatment for schizophrenia

Cioffi, Christopher L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

11

Discovery of highly potent and selective D4 ligands by interactive SAR study

Abdelfattah, Mohamed A.O., Lehmann, Jochen, Abadi, Ashraf H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 683 KB

english, 2013

12

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

Lee, Wendy, Ortwine, Daniel F., Bergeron, Philippe, Lau, Kevin, Lin, Lichuan, Malek, Shiva, Nonomiya, Jim, Pei, Zhonghua, Robarge, Kirk D., Schmidt, Stephen, Sideris, Steve, Lyssikatos, Joseph P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

13

Novel cycloalkylthiophene–imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation

Ke, Shaoyong, Wei, Yanhong, Yang, Ziwen, Wang, Kaimei, Liang, Ying, Shi, Liqiao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 624 KB

english, 2013

14

Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents

Zhang, Lei, Chai, Xiaoyun, Wang, Baogang, Yu, Shichong, Hu, Honggang, Zou, Yan, Zhao, Qingjie, Meng, Qingguo, Wu, Qiuye

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 712 KB

english, 2013

15

One-pot synthesis and cytotoxicity studies of new Mannich base derivatives of polyether antibiotic—Lasalocid acid

Huczyński, Adam, Rutkowski, Jacek, Borowicz, Izabela, Wietrzyk, Joanna, Maj, Ewa, Brzezinski, Bogumil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 324 KB

english, 2013

16

The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors

Chen, Jing, Jiang, Cheng-Shi, Ma, Wen-Quan, Gao, Li-Xin, Gong, Jing-Xu, Li, Jing-Ya, Li, Jia, Guo, Yue-Wei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.04 MB

english, 2013

17

Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells

Matsumoto, Takahiro, Nakamura, Seikou, Nakashima, Souichi, Yoshikawa, Masayuki, Fujimoto, Katsuyoshi, Ohta, Tomoe, Morita, Azumi, Yasui, Rie, Kashiwazaki, Eri, Matsuda, Hisashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 676 KB

english, 2013

18

A synthetic approach to novel carvotacetone and antheminone analogues with anti-tumour activity

Christou, Stephania, Ozturk, Emel, Pritchard, Robin G., Quayle, Peter, Stratford, Ian J., Whitehead, Roger C., Williams, Katharine F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 496 KB

english, 2013

19

A new strategy for the synthesis of crucigasterin A, and cytotoxic activity of this compound and its related analogues

Kumar, Jayprakash Narayan, Reddy, Parigi Raghavendar, Das, Biswanath, Kumar, C. Ganesh, Sujitha, Pombala

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 530 KB

english, 2013

20

Synthesis, DNA binding and anti-leukemic activity of an aminoacyl nucleolipid

Patel, Pradeepkumar, Hanawa, Emi, Yadav, Reeta, Samuni, Uri, Marzabadi, Cecilia, Sabatino, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

21

Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: Preliminary results on the role of electronic characteristics for affinity and function

Yuan, Yunyun, Elbegdorj, Orgil, Beletskaya, Irina O., Selley, Dana E., Zhang, Yan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 545 KB

english, 2013

22

New phenstatin–fatty acid conjugates: Synthesis and evaluation

Chen, Jinhui, Brown, David P., Wang, Yi-Jun, Chen, Zhe-Sheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

23

Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents

Suryawanshi, S.N., Kumar, Santosh, Shivahare, Rahul, Pandey, Susmita, Tiwari, Avinash, Gupta, Suman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 507 KB

english, 2013

24

Design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazoles as possible antimicrobial and antitubercular agents

Ranjith, P. Karuvalam, Rajeesh, P., Haridas, Karickal R., Susanta, Nayak K., Guru Row, Tayur N., Rishikesan, R., Suchetha Kumari, N.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 775 KB

english, 2013

25

Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora

Shrestha, Sabina, Natarajan, Sathishkumar, Park, Ji-Hae, Lee, Dae-Young, Cho, Jin-Gyeong, Kim, Geum-Soog, Jeon, Yong-Jin, Yeon, Seung-Woo, Yang, Deok-Chun, Baek, Nam-In

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

26

Chemical variation from the neoantimycin depsipeptide assembly line

Li, Xiang, Zvanych, Rostyslav, Vanner, Stephanie A., Wang, Wenliang, Magarvey, Nathan A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 739 KB

english, 2013

27

A novel protocol to accelerate dynamic combinatorial chemistry via isolation of ligand–target adducts from dynamic combinatorial libraries: A case study identifying competitive inhibitors of lysozyme

Fang, Zheng, He, Wei, Li, Xin, Li, Zhengjiang, Chen, Beining, Ouyang, Pingkai, Guo, Kai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 850 KB

english, 2013

28

The discovery of inhibitors of Fas-mediated cell death pathway using the combined computational method

Jung, Seo Hee, Suh, Ji Hee, Kim, Eun Hee, Kim, Jun Tae, Yoo, Seung-Eun, Kang, Nam Sook

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 4.19 MB

english, 2013

29

Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH

Sunohara, Kazuhiro, Mitsuhashi, Shinya, Shigetomi, Kengo, Ubukata, Makoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 968 KB

english, 2013

30

Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators

Ramos-Hunter, Susan J., Engers, Darren W., Kaufmann, Kristian, Du, Yu, Lindsley, Craig W., Weaver, C. David, Sulikowski, Gary A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 933 KB

english, 2013

31

Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold

Bolton, Scott A., Sutton, James C., Anumula, Rushith, Bisacchi, Gregory S., Jacobson, Bruce, Slusarchyk, William A., Treuner, Uwe D., Wu, Shung C., Zhao, Guohua, Pi, Zulan, Sheriff, Steven, Smirk, Reb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.05 MB

english, 2013

32

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.44 MB

english, 2013

33

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 30 KB

english, 2013

34

Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors

Kumar, Ashutosh, Ito, Akihiro, Hirohama, Mikako, Yoshida, Minoru, Zhang, Kam Y.J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 915 KB

english, 2013

35

N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile

Weltrowska, Grazyna, Nguyen, Thi M.-D., Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 527 KB

english, 2013

36

Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels

Pérez-Medina, Carlos, Patel, Niral, Robson, Mathew, Lythgoe, Mark F., Årstad, Erik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 649 KB

english, 2013

37

Fluorescence detection of cationic amyloid fibrils in human semen

Easterhoff, David, DiMaio, John T.M., Liyanage, Wathsala, Lo, Chi-Wen, Bae, Woori, Doran, Todd M., Smrcka, Alan, Nilsson, Bradley L., Dewhurst, Stephen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 786 KB

english, 2013

38

Computational studies of novel carbonyl-containing diazabicyclic ligands interacting with α4β2 nicotinic acetylcholine receptor (nAChR) reveal alternative binding modes

Kombo, David C., Mazurov, Anatoly A., Strachan, Jon-Paul, Bencherif, Merouane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.02 MB

english, 2013

39

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors

Li, Bei, Cociorva, Oana M., Nomanbhoy, Tyzoon, Weissig, Helge, Li, Qiang, Nakamura, Kai, Liyanage, Marek, Zhang, Melissa C., Shih, Ann Y., Aban, Arwin, Hu, Yi, Cajica, Julia, Pham, Lan, Kozarich, John

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.00 MB

english, 2013

40

Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching

Chu, Shidong, Gochin, Miriam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

41

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead

Cheng, Yung-Yi, Liu, Chin-Yu, Tsai, Meng-Tung, Lin, Hui-Yi, Yang, Jai-Sing, Wu, Tian-Shung, Kuo, Sheng-Chu, Huang, Li-Jiau, Lee, Kuo-Hsiung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

42

Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT

Pathuri, Gopal, Hedrick, Andria F., Awasthi, Vibhudutta, Ihnat, Michael A., Gali, Hariprasad

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 862 KB

english, 2013

43

New strigolactone mimics: Structure–activity relationship and mode of action as germinating stimulants for parasitic weeds

Zwanenburg, Binne, Nayak, Sandip K., Charnikhova, Tatsiana V., Bouwmeester, Harro J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 754 KB

english, 2013

44

Native chemical ligation derived method for recombinant peptide/protein C-terminal amidation

Sun, Chengzao, Luo, Gary, Neravetla, Swetha, Ghosh, Soumitra S., Forood, Bruce

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 962 KB

english, 2013

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