Volume 24; Issue 11

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Bioorganic & Medicinal Chemistry Letters
Volume 24; Issue 11

Bioorganic & Medicinal Chemistry Letters

Volume 24; Issue 11

1

Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors

Choi, Minho, Hwang, Young-Sik, Kumar, Arepalli Sateesh, Jo, Hyeju, Jeong, Yeongeun, Oh, Yunju, Lee, Joonkwang, Yun, Jieun, Kim, Youngsoo, Han, Sang-bae, Jung, Jae-Kyung, Cho, Jungsook, Lee, Heesoon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 334 KB

english, 2014

2

A chiral benzoylthiourea–pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones

Ban, Shu-rong, Zhu, Xi-xia, Zhang, Zhi-ping, Li, Qing-shan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 671 KB

english, 2014

3

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

Guo, Wenxing, Wisniewski, John A., Ji, Haitao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

4

Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives

More, Kunal N., Jang, Hyo Weon, Hong, Victor S., Lee, Jinho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

5

Synthesis and structure–activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists

Ye, Xiang-Yang, Morales, Christian L., Wang, Ying, Rossi, Karen A., Malmstrom, Sarah E., Abousleiman, Mojgan, Sereda, Larisa, Apedo, Atsu, Robl, Jeffrey A., Miller, Keith J., Krupinski, John, Wacker,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.56 MB

english, 2014

6

The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation

Edman, Karl, Ahlgren, Ragnhild, Bengtsson, Malena, Bladh, Håkan, Bäckström, Stefan, Dahmén, Jan, Henriksson, Krister, Hillertz, Per, Hulikal, Vijakumar, Jerre, Anders, Kinchin, Liz, Kåse, Charlotte, L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.07 MB

english, 2014

7

Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori

Tseng, Yen-Yu, Liou, Jyh-Ming, Hsu, Tsui-Ling, Cheng, Wei-Chieh, Wu, Ming-Shiang, Wong, Chi-Huey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 528 KB

english, 2014

8

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor

Basham, Kaitlin J., Bhonde, Vasudev R., Kieffer, Collin, Mack, James B.C., Hess, Matthew, Welm, Bryan E., Looper, Ryan E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

9

Coumestrol suppresses hypoxia inducible factor 1α by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells

Cho, Sung-Yun, Cho, Sunmi, Park, Eunkyung, Kim, Bonglee, Sohn, Eun Jung, Oh, Bumsuk, Lee, Eun-Ok, Lee, Hyo-Jeong, Kim, Sung-Hoon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 755 KB

english, 2014

10

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Volgraf, Matthew, Chan, Lina, Huestis, Malcolm P., Purkey, Hans E., Burkard, Michael, Geck Do, Mary, Harris, Julie, Hunt, Kevin W., Liu, Xingrong, Lyssikatos, Joseph P., Rana, Sumeet, Thomas, Allen A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

11

Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain

Fuwa, Haruhiko, Noguchi, Takuma, Kawakami, Masato, Sasaki, Makoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

12

Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking

Zhao, Hongtao, Gartenmann, Lisa, Dong, Jing, Spiliotopoulos, Dimitrios, Caflisch, Amedeo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 743 KB

english, 2014

13

2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists

Hu, Carol H., Qiao, Jennifer X., Han, Ying, Wang, Tammy C., Hua, Ji, Price, Laura A., Wu, Qimin, Shen, Hong, Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

14

Synthesis and radical-scavenging activity of a dimethyl catechin analogue

Imai, Kohei, Nakanishi, Ikuo, Ohno, Akiko, Kurihara, Masaaki, Miyata, Naoki, Matsumoto, Ken-ichiro, Nakamura, Asao, Fukuhara, Kiyoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 717 KB

english, 2014

15

Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase

Tollas, Szilvia, Bereczki, Ilona, Borbás, Anikó, Batta, Gyula, Vanderlinden, Evelien, Naesens, Lieve, Herczegh, Pál

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 406 KB

english, 2014

16

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents

Muthyala, Ramaiah, Rastogi, Namrata, Shin, Woo Shik, Peterson, Marnie L., Sham, Yuk Yin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 849 KB

english, 2014

17

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Higgins, Catherine, Bouazzaoui, Samira, Gaddale, Kishore, D’Costa, Zenobia, Templeman, Amy, O’Rourke, Martin, Young, Andrew, Scott, Christopher, Harrison, Tim, Mullan, Paul, Williams, Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 584 KB

english, 2014

18

Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action

Kisin-Finfer, Einat, Ferber, Shiran, Blau, Rachel, Satchi-Fainaro, Ronit, Shabat, Doron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

19

Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach

Elkaim, Judith, Lamblin, Marc, Laguerre, Michel, Rosenbaum, Jean, Lestienne, Patrick, Eloy, Laure, Cresteil, Thierry, Felpin, François-Xavier, Dessolin, Jean

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 572 KB

english, 2014

20

Antimalarial chemotherapy: Artemisinin-derived dimer carbonates and thiocarbonates

Mazzone, Jennifer R., Conyers, Ryan C., Tripathi, Abhai K., Sullivan, David J., Posner, Gary H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 652 KB

english, 2014

21

Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors

Rafferty, Stephen W., Eisner, Joel R., Moore, William R., Schotzinger, Robert J., Hoekstra, William J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 769 KB

english, 2014

22

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Pastor, Richard M., Burch, Jason D., Magnuson, Steven, Ortwine, Daniel F., Chen, Yuan, De La Torre, Kelly, Ding, Xiao, Eigenbrot, Charles, Johnson, Adam, Liimatta, Marya, Liu, Yichin, Shia, Steven, Wa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.73 MB

english, 2014

23

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Mori, Mattia, Moraca, Francesca, Deodato, Davide, Ferraris, Davide M., Selchow, Petra, Sander, Peter, Rizzi, Menico, Botta, Maurizio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 507 KB

english, 2014

24

Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors

Pulgar, Victor M., Keith Harp, Jill

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 422 KB

english, 2014

25

11C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

Andersen, Valdemar L., Hansen, Hanne D., Herth, Matthias M., Knudsen, Gitte M., Kristensen, Jesper L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 722 KB

english, 2014

26

Corrigendum to “Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling” [Bioorg. Med. Chem. Lett. 24 (2014) 294–297]

Hu, Jianlin, Chen, Yuqi, Xu, Xiaowei, Wu, Fan, Xing, Xiwen, Xu, Zhenghao, Xu, Jiahui, Weng, Xiaocheng, Zhou, Xiang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 182 KB

english, 2014

27

In vitro effect of a synthesized sulfonamido-based gallate on articular chondrocyte metabolism

Lin, Xiao, Zheng, Li, Liu, Qin, Liu, Buming, Jiang, Bingli, Peng, Xiaoyu, Lin, Cuiwu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 6.52 MB

english, 2014

28

Tomensides A–D, new antiproliferative phenylpropanoid sucrose esters from Prunus tomentosa leaves

Zhao, Wei, Huang, Xiao-Xiao, Yu, Li-Hong, Liu, Qing-Bo, Li, Ling-Zhi, Sun, Qian, Song, Shao-Jiang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 415 KB

english, 2014

29

Mechanistic aspects of the tyrosinase oxidation of hydroquinone

Ramsden, Christopher A., Riley, Patrick A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 422 KB

english, 2014

30

Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors

Woo, Jimin, Kim, Hyun-Young, Byun, Byung Jin, Chae, Chong-Hak, Lee, Ji Young, Ryu, Shi Yong, Park, Woo-Kyu, Cho, Heeyeong, Choi, Gildon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.78 MB

english, 2014

31

The discovery of diazepinone-based 5-HT3 receptor partial agonists

Manning, David D., Guo, Cheng, Zhang, Zhenjun, Ryan, Kristen N., Naginskaya, Jennifer, Choo, Sok Hui, Masih, Liaqat, Earley, William G., Wierschke, Jonathan D., Newman, Amy S., Brady, Catherine A., Ba

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 643 KB

english, 2014

32

Tyrosine phosphorylation of β-catenin affects its subcellular localization and transcriptional activity of β-catenin in Hela and Bcap-37 cells

Qian, He-Ya, Zhang, Ding-Guo, Wang, Hong-Wei, Pei, Dong-Sheng, Zheng, Jun-Nian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

33

Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens

Lin, Ting, Wang, Guanghui, Shan, Wenjun, Zeng, Dequan, Ding, Rong, Jiang, Xin, Zhu, Dan, Liu, Xiaoxuan, Yang, Shuiyuan, Chen, Haifeng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 656 KB

english, 2014

34

Chrotacumines G–J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity

Morita, Hiroshi, Nugroho, Alfarius Eko, Nagakura, Yuta, Hirasawa, Yusuke, Yoshida, Haruka, Kaneda, Toshio, Shirota, Osamu, Ismail, Intan Safinar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 309 KB

english, 2014

35

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 30 KB

english, 2014

36

Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin

Hodnik, Žiga, Łoś, Joanna M., Žula, Aleš, Zidar, Nace, Jakopin, Žiga, Łoś, Marcin, Sollner Dolenc, Marija, Ilaš, Janez, Węgrzyn, Grzegorz, Peterlin Mašič, Lucija, Kikelj, Danijel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 587 KB

english, 2014

37

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Ren, Jing, Li, Jian, Wang, Yueqin, Chen, Wuyan, Shen, Aijun, Liu, Hongchun, Chen, Danqi, Cao, Danyan, Li, Yanlian, Zhang, Naixia, Xu, Yechun, Geng, Meiyu, He, Jianhua, Xiong, Bing, Shen, Jingkang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.38 MB

english, 2014

38

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 3.29 MB

english, 2014

39

Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel

Sharma, Lalit Kumar, Cupit, Pauline M., Goronga, Tino, Webb, Thomas R., Cunningham, Charles

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 601 KB

english, 2014

40

Corrigendum to “Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23)” [Bioorg. Med. Chem. Lett. 23 (2013) 5361–5366]

Biftu, Tesfaye, Qian, Xiaoxia, Chen, Ping, Feng, Dennis, Scapin, Giovanna, Gao, Ying-Duo, Cox, Jason, Roy, Ranabir Sinha, Eiermann, George, He, Huabing, Lyons, Kathy, Salituro, Gino, Patel, Sangita, P

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 186 KB

english, 2014

41

Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors

Lu, Hejun, Tu, Wangyang, Fei, Hongbo, Xu, Guoji, Hu, Qiyue, Zhang, Lei, Lin, Bing, Yuan, Jijun, Yin, Junzhao, Gong, Aishen, Wan, Mimi, Wang, Dan, Zhu, Xiaoyan, Feng, Jun, Wang, Qian, Sun, Piaoyang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

42

Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure–bioactivity relationship

Bao, Jie, Luo, Jin-Feng, Qin, Xiao-Chu, Xu, Xin-Ya, Zhang, Xiao-Yong, Tu, Zheng-Chao, Qi, Shu-Hua

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 484 KB

english, 2014

43

Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands

Qiu, Xin, Zhao, Guo-Dong, Tang, Long-Qiang, Liu, Zhao-Peng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 838 KB

english, 2014

44

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

Zheng, Zhong, Parsons, Joshua B., Tangallapally, Rajendra, Zhang, Weixing, Rock, Charles O., Lee, Richard E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.68 MB

english, 2014

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