Volume 24; Issue 20

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Bioorganic & Medicinal Chemistry Letters
Volume 24; Issue 20

Bioorganic & Medicinal Chemistry Letters

Volume 24; Issue 20

1

Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents

Sashidhara, Koneni V., Rao, K. Bhaskara, Singh, Seema, Modukuri, Ram K., Aruna Teja, G., Chandasana, Hardik, Shukla, Shubha, Bhatta, Rabi S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 786 KB

english, 2014

2

Synthesis and characterization of valyloxy methoxy luciferin for the detection of valacyclovirase and peptide transporter

Walls, Zachary F., Gupta, Sheeba Varghese, Amidon, Gordon L., Lee, Kyung-Dall

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 381 KB

english, 2014

3

Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists

Horan, Joshua C., Sanyal, Sulagna, Choi, Younggi, Hill-Drzewi, Melissa, Patnaude, Lori, Anderson, Shawn, Fogal, Steve, Mao, Can, Cook, Brian N., Gueneva-Boucheva, Kristina, Fisher, Michael B., Hickey,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.52 MB

english, 2014

4

Synthesis and anti-proliferative activities of new derivatives of embelin

Singh, Baljinder, Guru, Santosh K., Sharma, Rashmi, Bharate, Sonali S., Khan, Inshad Ali, Bhushan, Shashi, Bharate, Sandip B., Vishwakarma, Ram A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

5

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Wang, Yue-Hu, Goto, Masuo, Wang, Li-Ting, Hsieh, Kan-Yen, Morris-Natschke, Susan L., Tang, Gui-Hua, Long, Chun-Lin, Lee, Kuo-Hsiung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 493 KB

english, 2014

6

Anti-tumor activity of novel biisoquinoline derivatives against breast cancers

Jaiswal, Aruna S., Hirsch-Weil, Dimitri, Proulx, Erick R., Hong, Sukwon, Narayan, Satya

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 758 KB

english, 2014

7

Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation

Liu, Hong-Fei, Wan, Ning, Huan, Meng-Lei, Jia, Yi-Yang, Yuan, Xiao-Feng, Zhou, Si-Yuan, Zhang, Bang-Le

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 670 KB

english, 2014

8

A 68Ga complex based on benzofuran scaffold for the detection of β-amyloid plaques

Watanabe, Hiroyuki, Ono, Masahiro, Iikuni, Shimpei, Yoshimura, Masashi, Matsumura, Kenji, Kimura, Hiroyuki, Saji, Hideo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 556 KB

english, 2014

9

The design and implementation of a generic lipopeptide scanning platform to enable the identification of ‘locally acting’ agonists for the apelin receptor

McKeown, Stephen C., Zecri, Frederic J., Fortier, Eric, Taggart, Andrew, Sviridenko, Lilya, Adams, Christopher M., McAllister, Kathryn H., Pin, Sokhom S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

10

Novel dammarane saponins from Gynostemma pentaphyllum and their cytotoxic activities against HepG2 cells

Piao, Xiang-Lan, Xing, Shao-Fang, Lou, Cai-Xia, Chen, Dao-Jin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 430 KB

english, 2014

11

5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R

Bernard-Gauthier, Vadim, Schirrmacher, Ralf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.44 MB

english, 2014

12

Structure-Plant Phytotoxic Activity Relationship of 7,7′-epoxylignanes, (+)- and (−)-verrucosin: Simplification on the aromatic ring substituents

Yamauchi, Satoshi, Nakayama, Kumiko, Nishiwaki, Hisashi, Shuto, Yoshihiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 992 KB

english, 2014

13

The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors

Sodji, Quaovi, Patil, Vishal, Jain, Surendra, Kornacki, James R., Mrksich, Milan, Tekwani, Babu L., Oyelere, Adegboyega K.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 522 KB

english, 2014

14

Synthesis and evaluation of anti-inflammatory activity of derivatives of the marine natural products fuscol and eunicol

Kerr, Russell G., Brophy, Shawn, Derksen, Darren J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 427 KB

english, 2014

15

Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

Roecker, Anthony J., Reger, Thomas S., Mattern, M. Christa, Mercer, Swati P., Bergman, Jeffrey M., Schreier, John D., Cube, Rowena V., Cox, Christopher D., Li, Dansu, Lemaire, Wei, Bruno, Joseph G., H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 503 KB

english, 2014

16

Enzymatic preparation of optically pure (+)-2-azabicyclo[2.2.1]hept-5-en-3-one by (−)-γ-lactamase from Bradyrhizobium japonicum USDA 6

Zhu, Shaozhou, Ren, Lu, Yu, Songzhu, Gong, Cuiyu, Song, Dawei, Zheng, Guojun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

17

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies

Hirayama, Shigeto, Wada, Naohisa, Kuroda, Naoya, Iwai, Takashi, Yamaotsu, Noriyuki, Hirono, Shuichi, Fujii, Hideaki, Nagase, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 594 KB

english, 2014

18

Centrifugation aided highly sensitive detection of nitrite with a dye–silica conjugate featuring cleavable linkages

Xu, Hehuan, Xue, Zhongwei, Han, Jiahuai, Su, Xinhui, Han, Shoufa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 936 KB

english, 2014

19

Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension

Shaw, Duncan, Hollingworth, Greg, Soldermann, Nicolas, Sprague, Elizabeth, Schuler, Walter, Vangrevelinghe, Eric, Duggan, Nicholas, Thomas, Matthew, Kosaka, Takatoshi, Waters, Nigel, van Eis, Maurice

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.66 MB

english, 2014

20

Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities

Madabhushi, Sridhar, Mallu, Kishore Kumar Reddy, Vangipuram, Venkata Sairam, Kurva, Srinivas, Poornachandra, Y., Ganesh Kumar, C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 542 KB

english, 2014

21

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors

Banerjee, Abhisek, Pawar, Mahesh Y., Patil, Sandip, Yadav, Pravin S., Kadam, Pradip A., Kattige, Vidya G., Deshpande, Durga S., Pednekar, Pallavi V., Pisat, Monali K., Gharat, Laxmikant A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 615 KB

english, 2014

22

Poly-guanidinoethylphenylethers organised around a benzene ring: Synthesis and evaluation of their antibacterial and cytotoxic properties

Massimba Dibama, Hugues, Mourer, Maxime, Duval, Raphaël E., Regnouf-de-Vains, Jean-Bernard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 427 KB

english, 2014

23

X-ray crystallographic analysis of IMP-1 metallo-β-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors

Hiraiwa, Yukiko, Saito, Jun, Watanabe, Takashi, Yamada, Mototsugu, Morinaka, Akihiro, Fukushima, Takayoshi, Kudo, Toshiaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 893 KB

english, 2014

24

Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP

Lee, Phil Jun, Shin, Iljin, Seo, Seung-Yong, Kim, Hyoungsu, Kim, Hong Pyo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

25

Synthesis and bioluminescence of difluoroluciferin

Pirrung, Michael C., Biswas, Goutam, De Howitt, Natalie, Liao, Jiayu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 466 KB

english, 2014

26

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors

Drung, Binia, Scholz, Christoph, Barbosa, Valéria A., Nazari, Azadeh, Sarragiotto, Maria H., Schmidt, Boris

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.90 MB

english, 2014

27

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 30 KB

english, 2014

28

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

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