Volume 24; Issue 23

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Bioorganic & Medicinal Chemistry Letters
Volume 24; Issue 23

Bioorganic & Medicinal Chemistry Letters

Volume 24; Issue 23

1

Synthesis of novel triazole-linked mefloquine derivatives: Biological evaluation against Plasmodium falciparum

Hamann, Anton R., de Kock, Carmen, Smith, Peter J., van Otterlo, Willem A.L., Blackie, Margaret A.L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 545 KB

english, 2014

2

Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo[2,1-b]thiazoles

Koppireddi, Satish, Chilaka, Deepika Raj Kumari, Avula, Sreenivas, Komsani, Jayaram Reddy, Kotamraju, Srigiridhar, Yadla, Rambabu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 350 KB

english, 2014

3

3-Arylcoumarins: Synthesis and potent anti-inflammatory activity

Pu, Wenchen, Lin, Yuan, Zhang, Jianshuo, Wang, Fei, Wang, Chun, Zhang, Guolin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 547 KB

english, 2014

4

2-Butyl-4-chloroimidazole based substituted piperazine-thiosemicarbazone hybrids as potent inhibitors of Mycobacterium tuberculosis

Jallapally, Anvesh, Addla, Dinesh, Yogeeswari, Perumal, Sriram, Dharmarajan, Kantevari, Srinivas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 841 KB

english, 2014

5

Antibody–drug conjugates—A new wave of cancer drugs

Bouchard, Hervé, Viskov, Christian, Garcia-Echeverria, Carlos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 702 KB

english, 2014

6

7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors

Grant, Eugene B., Foleno, Barbara D., Goldschmidt, Raul, Hilliard, Jamese J., Lin, Shu-Chen, Morrow, Brian, Paget, Steven D., Weidner-Wells, Michele A., Xu, Xiaodong, Xu, Xiaoqing, Murray, William V.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 869 KB

english, 2014

7

Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells

Kang, Seoung Mook, Lee, Jinsung, Jin, Jae Ho, Kim, Minju, Lee, Sunhoe, Lee, Hwi Ho, Shin, Ji-Sun, Lee, Kyung-Tae, Lee, Jae Yeol

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 848 KB

english, 2014

8

Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity

Liebens, Veerle, Gerits, Evelien, Knapen, Wouter J., Swings, Toon, Beullens, Serge, Steenackers, Hans P., Robijns, Stijn, Lippell, Anna, O’Neill, Alex J., Veber, Matija, Fröhlich, Mirjam, Krona, Annik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 714 KB

english, 2014

9

Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity

Maccari, Giorgio, Sanfilippo, Stefania, De Luca, Filomena, Deodato, Davide, Casian, Alexandru, Dasso Lang, Maria Chiara, Zamperini, Claudio, Dreassi, Elena, Rossolini, Gian Maria, Docquier, Jean-Denis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.18 MB

english, 2014

10

Discovery of potent iminoheterocycle BACE1 inhibitors

Caldwell, John P., Mazzola, Robert D., Durkin, James, Chen, Joseph, Chen, Xia, Favreau, Leonard, Kennedy, Matthew, Kuvelkar, Reshma, Lee, Julie, McHugh, Nansie, McKittrick, Brian, Orth, Peter, Stamfor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

11

Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging

Nebel, Natascha, Maschauer, Simone, Bartuschat, Amelie L., Fehler, Stefanie K., Hübner, Harald, Gmeiner, Peter, Kuwert, Torsten, Heinrich, Markus R., Prante, Olaf, Hocke, Carsten

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 429 KB

english, 2014

12

Amino acidic scaffolds bearing unnatural side chains: An old idea generates new and versatile tools for the life sciences

Stevenazzi, Andrea, Marchini, Mattia, Sandrone, Giovanni, Vergani, Barbara, Lattanzio, Maria

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

13

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist

Ohmi, Masashi, Shishido, Yuji, Inoue, Tadashi, Ando, Kazuo, Fujiuchi, Akiyoshi, Yamada, Akiko, Watanabe, Shuzo, Kawamura, Kiyoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 889 KB

english, 2014

14

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

Sola, Irene, Artigas, Albert, Taylor, Martin C., Gbedema, Stephen Y., Pérez, Belén, Clos, M. Victòria, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 350 KB

english, 2014

15

Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity

Kuang, Xingzhu, Li, Wei, Kanno, Yuichiro, Mochizuki, Michiru, Inouye, Yoshio, Koike, Kazuo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 628 KB

english, 2014

16

A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC− transporter

Yang, Hua, Miao, Qing, Johnson, Bruce F., Rishel, Michael J., Sossi, Vesna, Dinelle, Katherine, Bénard., François, Yapp, Donald T., Webster, Jack M., Schaffer, Paul

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 921 KB

english, 2014

17

Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform

Blackburn, Christopher, Barrett, Cynthia, Brunson, Mable, Chin, Janice, England, Dylan, Garcia, Kris, Gigstad, Kenneth, Gould, Alexandra, Gutierrez, Juan, Hoar, Kara, Rowland, R. Scott, Tsu, Christoph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 594 KB

english, 2014

18

A natural phenylpropionate derivative from Mirabilis himalaica inhibits cell proliferation and induces apoptosis in HepG2 cells

Lang, LingHu, Zhu, Shunqin, Zhang, Haoxing, Yang, Panpan, Fan, Haixia, Li, Shanlin, Liao, Zhihua, Lan, Xiaozhong, Cui, Hongjuan, Chen, Min

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.71 MB

english, 2014

19

Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells

Tao, Li, Xie, Jianmei, Wang, Yuting, Wang, Shi, Wu, Shuangchan, Wang, Qiman, Ding, Hong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

20

Amine-linked diquercitols as new α-glucosidase inhibitors

Worawalai, Wisuttaya, Wacharasindhu, Sumrit, Phuwapraisirisan, Preecha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 884 KB

english, 2014

21

Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids

Shankaraiah, Nagula, Nekkanti, Shalini, Chudasama, Karmarajsinh J., Senwar, Kishna Ram, Sharma, Pankaj, Jeengar, Manish Kumar, Naidu, V.G.M., Srinivasulu, Vunnam, Srinivasulu, Gannoju, Kamal, Ahmed

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

22

‘Naked-eye’ quinoline-based ‘reactive’ sensor for recognition of Hg2+ ion in aqueous solution

Zhang, Yanhua, Yan, Yuanyuan, Chen, Suying, Gao, Zhinan, Xu, Hui

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

23

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Azimioara, Mihai, Alper, Phil, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mecom, John, McNeill, Matthew, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 851 KB

english, 2014

24

Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors

Kim, Junwon, Kwon, Jeongjin, Lee, Doohyun, Jo, Suyeon, Park, Dong-Sik, Choi, Jihyun, Park, Eunjung, Hwang, Jong Yeon, Ko, Yoonae, Choi, Inhee, Ju, Moon Kyeong, Ahn, JiYe, Kim, Junghwan, Han, Sung-Jun,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.25 MB

english, 2014

25

Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-aminopiperidine derivatives

Vilums, M., Zweemer, A.J.M., Dekkers, S., Askar, Y., de Vries, H., Saunders, J., Stamos, D., Brussee, J., Heitman, L.H., IJzerman, A.P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

26

Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 655 KB

english, 2014

27

Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation

Qu, Fan-Zhi, Liu, Ya-Fei, Cao, Jia-Qing, Wang, Xu-De, Zhang, Xiao-Shu, Zhao, Chen, Zhao, Yu-Qing

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 480 KB

english, 2014

28

Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents

Joubert, Jacques, Fortuin, Elton E., Taylor, Dale, Smith, Peter J., Malan, Sarel F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 394 KB

english, 2014

29

The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.52 MB

english, 2014

30

Lithocarpic acids O–S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus

Ning, Ruo-nan, Wang, Hong-min, Shen, Yu, Chen, Zhen-hua, Zhang, Ru-jun, Leng, Ying, Zhao, Wei-min

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 520 KB

english, 2014

31

2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists

Lu, Hongfu, Yang, Ting, Xu, Zhongmiao, Wren, Paul B., Zhang, Yueting, Cai, Xin, Patel, Metul, Dong, Kelly, Zhang, Qing, Zhang, Wei, Guan, Xiaoming, Xiang, Jianing, Elliott, John D., Lin, Xichen, Ren,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

32

Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model

Mishra, Rajesh Kumar, Baker, Max T.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 323 KB

english, 2014

33

The effect of pKa on pyrimidine/pyridine-derived histamine H4 ligands

Savall, Brad M., Meduna, Steven P., Venable, Jennifer, Wei, Jianmei, Smith, Russell C., Hack, Michael D., Thurmond, Robin L., McGovern, Patricia, Edwards, James P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 912 KB

english, 2014

34

Tritium-labeled (E,E)-2,5-bis(4′-hydroxy-3′-carboxystyryl)benzene as a probe for β-amyloid fibrils

Matveev, Sergey V., Kwiatkowski, Stefan, Sviripa, Vitaliy M., Fazio, Robert C., Watt, David S., LeVine, Harry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 465 KB

english, 2014

35

Aurones as histone deacetylase inhibitors: Identification of key features

Zwick, Vincent, Chatzivasileiou, Alkiviadis-Orfefs, Deschamps, Nathalie, Roussaki, Marina, Simões-Pires, Claudia A., Nurisso, Alessandra, Denis, Iza, Blanquart, Christophe, Martinet, Nadine, Carrupt,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.36 MB

english, 2014

36

Photo-dependent protein biosynthesis using a caged aminoacyl-tRNA

Akahoshi, Akiya, Doi, Yoshio, Sisido, Masahiko, Watanabe, Kazunori, Ohtsuki, Takashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 478 KB

english, 2014

37

Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes

Zhang, Yan, Shen, Mingyun, Cui, Sunliang, Hou, Tingjun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 475 KB

english, 2014

38

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels

Ortar, Giorgio, Schiano Moriello, Aniello, Morera, Enrico, Nalli, Marianna, Di Marzo, Vincenzo, De Petrocellis, Luciano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 678 KB

english, 2014

39

Inhibitory effects of ginseng sapogenins on the proliferation of triple negative breast cancer MDA-MB-231 cells

Kwak, Jin Ho, Park, Jun Yeon, Lee, Dahae, Kwak, Jae Young, Park, Eun Hwa, Kim, Ki Hyun, Park, Hye-Jin, Kim, Hyun Young, Jang, Hyuk Jai, Ham, Jungyeob, Hwang, Gwi Seo, Yamabe, Noriko, Kang, Ki Sung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 460 KB

english, 2014

40

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement

Tuyishime, Marina, Danish, Matt, Princiotto, Amy, Mankowski, Marie K., Lawrence, Rae, Lombart, Henry-Georges, Esikov, Kirill, Berniac, Joel, Liang, Kuang, Ji, Jingjing, Ptak, Roger G., Madani, Navid,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.49 MB

english, 2014

41

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 30 KB

english, 2014

42

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 3.06 MB

english, 2014

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