Volume 25; Issue 10

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Bioorganic & Medicinal Chemistry Letters
Volume 25; Issue 10

Bioorganic & Medicinal Chemistry Letters

Volume 25; Issue 10

1

Design strategies to address kinetics of drug binding and residence time

Cusack, Kevin P., Wang, Ying, Hoemann, Michael Z., Marjanovic, Jasmina, Heym, Roland G., Vasudevan, Anil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 582 KB

english, 2015

2

Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives

Wu, Wenneng, Chen, Qin, Tai, Anqi, Jiang, Guangqi, Ouyang, Guiping

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 571 KB

english, 2015

3

Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents

Yadagiri, Bandi, Gurrala, Srikanth, Bantu, Rajashaker, Nagarapu, Lingaiah, Polepalli, Sowjanya, Srujana, Garimella, Jain, Nishant

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 341 KB

english, 2015

4

Sulfamic acid promoted one-pot three-component synthesis and cytotoxic evaluation of spirooxindoles

Kamal, Ahmed, Babu, Korrapati Suresh, Vishnu Vardhan, M.V.P.S., Hussaini, S.M. Ali, Mahesh, Rasala, Shaik, Siddiq Pasha, Alarifi, Abdullah

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 930 KB

english, 2015

5

Dopamine D1 receptor-agonist interactions: A mutagenesis and homology modeling study

Mente, Scot, Guilmette, Edward, Salafia, Michelle, Gray, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 850 KB

english, 2015

6

Silver(I) complexes of 2,4-dihydroxybenzaldehyde–amino acid Schiff bases—Novel noncompetitive α-glucosidase inhibitors

Zheng, Jingwei, Ma, Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

7

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling

Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Sylvain, Catherine, Clough, Jeffrey, Carroll, David, Keim, Holger, Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Herlaar, Ellen, Issakani, Sarkiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 369 KB

english, 2015

8

Classifying shape coverage in fragment libraries using a fingerprinting approach

Richardson, Christine M., Lipkin, Michael J., Sheppard, David W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

9

‘Turn On/Off’ fluorescence probe for the screening of unactivated Bruton’s tyrosine kinase

Kawahata, Wataru, Asami, Tokiko, Fujii, Ikuo, Sawa, Masaaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 826 KB

english, 2015

10

TR-FRET binding assay targeting unactivated form of Bruton’s tyrosine kinase

Asami, Tokiko, Kawahata, Wataru, Sawa, Masaaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 505 KB

english, 2015

11

Pyridinic analog of the natural product (−)-spectaline as potential adjuvant for the treatment of central nervous system disorders

Valli, Marilia, Betti, Andresa Heemann, Danuello, Amanda, Pivatto, Marcos, Centurião, Fernanda, Antonio, Camila Boque, Rates, Stela Maris Kuze, Bolzani, Vanderlan da Silva

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 420 KB

english, 2015

12

Antibacterial activity of ruthenium(II) polypyridyl complex manipulated by membrane permeability and cell morphology

Sun, Dongdong, Zhang, Weiwei, Lv, Mengting, Yang, Endong, Zhao, Qian, Wang, Weiyun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 881 KB

english, 2015

13

Synthesis and structure–activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents

Xue, Tao, Ding, Shi, Guo, Bin, Chu, Wenjing, Wang, Hui, Yang, Yushe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.62 MB

english, 2015

14

Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

Faísca Phillips, Ana Maria, Nogueira, Fátima, Murtinheira, Fernanda, Barros, Maria Teresa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 324 KB

english, 2015

15

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs)

Arikawa, Yasuyoshi, Hasuoka, Atsushi, Nishida, Haruyuki, Hirase, Keizo, Inatomi, Nobuhiro, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Imanishi, Akio, Itoh, Fumio, Kajino, Masahiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 344 KB

english, 2015

16

Modulating Acinetobacter baumannii biofilm development with molecules containing 3,4,5-trimethoxy-N,N′,N′-trimethylbenzohydrazide moiety

Sambanthamoorthy, Karthik, Hickman, Mark, Pattabiraman, Nagarajan, Palys, Thomas, Wagar, Eric J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 920 KB

english, 2015

17

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents

Mishra, Ram C., Gundala, Sushma R., Karna, Prasanthi, Lopus, Manu, Gupta, Kamlesh K., Nagaraju, Mulpuri, Hamelberg, Donald, Tandon, Vibha, Panda, Dulal, Reid, Michelle D., Aneja, Ritu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.37 MB

english, 2015

18

Synthesis of mycothiol conjugate analogues and evaluation of their antimycobacterial activity

Riordan, Scott W., Field, Jessica J., Corkran, Hilary M., Dasyam, Nathaniel, Stocker, Bridget L., Timmer, Mattie S.M., Harvey, Joanne E., Teesdale-Spittle, Paul H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 672 KB

english, 2015

19

Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity

Sanabria-Ríos, David J., Rivera-Torres, Yaritza, Rosario, Joshua, Ríos, Camille, Gutierrez, Ricardo, Carballeira, Néstor M., Vélez, Christian, Zayas, Beatriz, Álvarez-Colón, Félix, Ortiz-Soto, Gabriel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

20

Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors

Chen, Jing, Gao, Li-Xin, Gong, Jing-Xu, Jiang, Cheng-Shi, Yao, Li-Gong, Li, Jing-Ya, Li, Jia, Xiao, Wei, Guo, Yue-Wei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.20 MB

english, 2015

21

Syntheses of natural 1,3-polyol/α-pyrone and its all stereoisomers to estimate antifungal activities against plant pathogenic fungi

Yamauchi, Satoshi, Isozaki, Yasuyoshi, Nishiwaki, Hisashi, Akiyama, Koichi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 677 KB

english, 2015

22

Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea

Sun, Shi, Canning, Corene B., Bhargava, Kanika, Sun, Xiuxiu, Zhu, Wenjun, Zhou, Ninghui, Zhang, Yifan, Zhou, Kequan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 304 KB

english, 2015

23

Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors

Glunz, Peter W., Cheng, Xuhong, Cheney, Daniel L., Weigelt, Carolyn A., Wei, Anzhi, Luettgen, Joseph M., Wong, Pancras C., Wexler, Ruth R., Priestley, E. Scott

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.83 MB

english, 2015

24

Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition

Leyva, Melissa J., Kim, Yeong Sang, Peach, Megan L., Schneekloth, John S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

25

Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations

Basak, Ajoy, Goswami, Mukunda, Rajkumar, Abishankari, Mitra, Tapobrata, Majumdar, Swapan, O’Reilly, Paul, Bdour, Hussam M., Trudeau, Vance L., Basak, Amit

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.56 MB

english, 2015

26

Synthesis of benzoxazole derivatives of honokiol as insecticidal agents against Mythimna separata Walker

Yang, Chun, Zhi, Xiaoyan, Xu, Hui

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

27

Cytotoxic and antioxidant constituents from the leaves of Psidium guajava

Feng, Xiao-he, Wang, Zi-hao, Meng, Da-li, Li, Xian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 357 KB

english, 2015

28

ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles

El-Damasy, Ashraf Kareem, Cho, Nam-Chul, Kang, Soon Bang, Pae, Ae Nim, Keum, Gyochang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

29

Strigolactam: New potent strigolactone analogues for the germination of Orobanche cumana

Lachia, Mathilde, Wolf, Hanno Christian, Jung, Pierre Joseph Marcel, Screpanti, Claudio, De Mesmaeker, Alain

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 613 KB

english, 2015

30

Development of a photolabile protecting group for phosphodiesters in oligonucleotides

Saneyoshi, Hisao, Shimamura, Kanami, Sagawa, Naoki, Ando, Yuki, Tomori, Takahito, Okamoto, Itaru, Ono, Akira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 909 KB

english, 2015

31

Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors

Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Carroll, David, Clough, Jeffrey, Keim, Holger, Sylvain, Catherine, Rossi, Alexander B., Coquilla, Christina, Issakani, Sarkiz D., Masuda, Esteban S.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 725 KB

english, 2015

32

Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.

Kim, Eun La, Wang, Haibo, Park, Ju Hee, Hong, Jongki, Choi, Jae Sue, Im, Dong Soon, Chung, Hae Young, Jung, Jee H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 560 KB

english, 2015

33

Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis

Stefańska, Joanna, Antoszczak, Michał, Stępień, Karolina, Bartoszcze, Michał, Mirski, Tomasz, Huczyński, Adam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 812 KB

english, 2015

34

Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Hsieh, Yi-Han, Liu, Kuang-Kai, Sulake, Rohidas S., Chao, Jui-I., Chen, Chinpiao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 576 KB

english, 2015

35

A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium

Mukerjee, Anindita, Iyidogan, Pinar, Castellanos-Gonzalez, Alejandro, Cisneros, José A., Czyzyk, Daniel, Ranjan, Amalendu Prakash, Jorgensen, William L., White, A. Clinton, Vishwanatha, Jamboor K., An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 585 KB

english, 2015

36

Synthesis and characterization of gadolinium—Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent

Kim, Young-Seung, Zhou, Yang, Bryant, Henry, Milenic, Diane E., Baidoo, Kwamena E., Lewis, Bobbi K., Frank, Joseph A., Brechbiel, Martin W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 621 KB

english, 2015

37

[13C3,15N1]-labeled isodesmosine: A potential internal standard for LC–MS/MS analysis of desmosines in elastin degradation

Tanigawa, Takahiro, Komatsu, Akira, Usuki, Toyonobu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 324 KB

english, 2015

38

PTP1B inhibitors from stems of Angelica keiskei (Ashitaba)

Li, Jin-long, Gao, Li-xin, Meng, Fan-wang, Tang, Chun-lan, Zhang, Ru-jun, Li, Jing-ya, Luo, Cheng, Li, Jia, Zhao, Wei-min

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 891 KB

english, 2015

39

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

Dockendorff, Chris, Faloon, Patrick W., Pu, Jun, Yu, Miao, Johnston, Stephen, Bennion, Melissa, Penman, Marsha, Nieland, Thomas J.F., Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Miche

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.92 MB

english, 2015

40

Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists

Hennessy, Edward J., Grewal, Gurmit, Byth, Kate, Kamhi, Victor M., Li, Danyang, Lyne, Paul, Oza, Vibha, Ronco, Lucienne, Rooney, Michael T., Saeh, Jamal C., Su, Qibin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

41

Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives

Liéby-Muller, Frédéric, Heudré Le Baliner, Quentin, Grisoni, Serge, Fournier, Emmanuel, Guilbaud, Nicolas, Marion, Frédéric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 490 KB

english, 2015

42

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

Thomas, James B., Giddings, Angela M., Olepu, Srinivas, Wiethe, Robert W., Warner, Keith R., Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P., Gilmour, Brian P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 717 KB

english, 2015

43

Facile design of organic–inorganic hybrid gels for molecular recognition of nucleoside triphosphates

Jeon, Jong-Hwan, Kakuta, Takahiro, Tanaka, Kazuo, Chujo, Yoshiki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.76 MB

english, 2015

44

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 31 KB

english, 2015

45

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 4.08 MB

english, 2015

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