Volume 25; Issue 12

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Bioorganic & Medicinal Chemistry Letters
Volume 25; Issue 12

Bioorganic & Medicinal Chemistry Letters

Volume 25; Issue 12

1

Separation and peroxisome proliferator-activated receptor-γ agonist activity evaluation of synthetic racemic bavachinin enantiomers

Du, Guoxin, Feng, Li, Yang, Zhuo, Shi, Jiye, Huang, Cheng, Guo, Fujiang, Li, Bo, Zhu, Weiliang, Li, Yiming

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 667 KB

english, 2015

2

Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB

Choi, Minho, Jo, Hyeju, Park, Hyun-Jung, Sateesh Kumar, Arepalli, Lee, Joonkwang, Yun, Jieun, Kim, Youngsoo, Han, Sang-bae, Jung, Jae-Kyung, Cho, Jungsook, Lee, Kiho, Kwak, Jae-Hwan, Lee, Heesoon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 404 KB

english, 2015

3

Isolation, semi-synthesis and bio-evaluation of spatane derivatives from the brown algae Stoechospermum marginatum

Chinnababu, B., Purushotham Reddy, S., Sankara Rao, P., Loka Reddy, V., Sudheer Kumar, B., Rao, J. Venkateswara, Prakasham, R.S., Suresh Babu, K.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 477 KB

english, 2015

4

An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica

Saruul, Erdenebileg, Murata, Toshihiro, Selenge, Erdenechimeg, Sasaki, Kenroh, Yoshizaki, Fumihiko, Batkhuu, Javzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 393 KB

english, 2015

5

Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells

Kim, Young-Joo, Kang, Ki Sung, Choi, Kyung-Chul, Ko, Hyeonseok

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 454 KB

english, 2015

6

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency

Wu, Yue, Hu, Mingyang, Yang, Li, Li, Xiang, Bian, Jinlei, Jiang, Fen, Sun, Haopeng, You, Qidong, Zhang, Xiaojin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 830 KB

english, 2015

7

Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors

Therrien, Eric, Larouche, Guillaume, Nguyen, Natalie, Rahil, Jubrail, Lemieux, Anne-Marie, Li, Zuomei, Fournel, Marielle, Yan, Theresa P., Landry, Anne-Julie, Lefebvre, Sylvain, Wang, James J., MacBet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 384 KB

english, 2015

8

Progress in discovery of small-molecule modulators of protein–protein interactions via fragment screening

Magee, Thomas V.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

9

Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice

Roopashree, Rangaswamy, Mohan, Chakrabhavi Dhananjaya, Swaroop, Toreshettahally Ramesh, Jagadish, Swamy, Raghava, Byregowda, Balaji, Kyathegowdanadoddi Srinivas, Jayarama, Shankar, Basappa,, Rangappa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 875 KB

english, 2015

10

Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin

Mutai, Peggoty, Pavadai, Elumalai, Wiid, Ian, Ngwane, Andile, Baker, Bienyameen, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 987 KB

english, 2015

11

Anticancer drug-based multifunctional nanogels through self-assembly of dextran–curcumin conjugates toward cancer theranostics

Nagahama, Koji, Sano, Yoshinori, Kumano, Takayuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 918 KB

english, 2015

12

Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities

Yan, Yong-Ming, Li, Li-Ji, Qin, Xiao-Chu, Lu, Qing, Tu, Zheng-Chao, Cheng, Yong-Xian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 460 KB

english, 2015

13

Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Clarke, Michael O., Mackman, Richard, Byun, Daniel, Hui, Hon, Barauskas, Ona, Birkus, Gabriel, Chun, Byoung-Kwon, Doerffler, Edward, Feng, Joy, Karki, Kapil, Lee, Gary, Perron, Michel, Siegel, Dustin,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 595 KB

english, 2015

14

Activity of lipo-cyclic γ-AApeptides against biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa

Padhee, Shruti, Li, Yaqiong, Cai, Jianfeng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

15

Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor

Raeppel, Stéphane L., Raeppel, Franck, Therrien, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

16

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3)

Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Gill, Charles, Black, Todd, Nargund, Ravi, Meinke, Peter T., Olsen, David B., Lagrutta, Armando, Wei, Changqing, Peng, Xua

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.98 MB

english, 2015

17

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties

Kuduk, Scott D., Skudlarek, Jason W., DiMarco, Christina N., Bruno, Joseph G., Pausch, Mark H., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Garson, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

18

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Edfeldt, Fredrik, Evenäs, Johan, Lepistö, Matti, Ward, Alison, Petersen, Jens, Wissler, Lisa, Rohman, Mattias, Sivars, Ulf, Svensson, Karin, Perry, Matthew, Feierberg, Isabella, Zhou, Xiao-Hong, Hanss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.24 MB

english, 2015

19

Design, synthesis and preliminary evaluation of 18F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor

Saccomanni, Giuseppe, Pascali, Giancarlo, Carlo, Sara Del, Panetta, Daniele, De Simone, Mariarosaria, Bertini, Simone, Burchielli, Silvia, Digiacomo, Maria, Macchia, Marco, Manera, Clementina, Salvado

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 895 KB

english, 2015

20

Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives

Chen, Zhong, Duan, Huaqing, Wang, Minglei, Han, Li, Liu, Yanli, Zhu, Yongming, Yang, Shilin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 559 KB

english, 2015

21

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Yu, Miao, Youngsaye, Willmen, Nag, Partha P., Bennion, Melissa, Penman, Marsha, Nieland, Thomas J.F., Dandapani, Sivaraman, Perez, José R., Mun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.54 MB

english, 2015

22

Parthenolide prodrug LC-1 slows growth of intracranial glioma

Hexum, Joseph K., Becker, Chani M., Kempema, Aaron M., Ohlfest, John R., Largaespada, David A., Harki, Daniel A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 341 KB

english, 2015

23

Design, synthesis and anticancer activity of matrine–1H-1,2,3-triazole–chalcone conjugates

Zhao, Lihui, Mao, Lina, Hong, Ge, Yang, Xiaojiao, Liu, Tianjun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 844 KB

english, 2015

24

N-Arylmethylaminoquercitols, a new series of effective antidiabetic agents having α-glucosidase inhibition and antioxidant activity

Worawalai, Wisuttaya, Wacharasindhu, Sumrit, Phuwapraisirisan, Preecha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 809 KB

english, 2015

25

Incorporation of an acyclic alkynyl nucleoside analog into siRNA improves silencing activity and nuclease resistance

Ogata, Aya, Ueno, Yoshihito

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 485 KB

english, 2015

26

Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen

Ley, Corinne R., Beattie, Nathan R., Dannoon, Shorouk, Regan, Melanie, VanBrocklin, Henry, Berkman, Clifford E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 681 KB

english, 2015

27

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers

Ivashkin, Pavel, Lemonnier, Gérald, Tora, Amélie S., Pin, Jean-Philippe, Goudet, Cyril, Jubault, Philippe, Pannecoucke, Xavier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 613 KB

english, 2015

28

Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay

Arns, Steve, Tan, Jason, Sun, Sharon, Galey, Adam, Zisman, Natalia, Ross, Fiona, Udechukwu, Jenna, Dercho, Samantha, Gusti, Vionarica, Paquette, Jay, Webb, Murray, Bourque, Elyse, Withers, Stephen G.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 706 KB

english, 2015

29

A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X

Gao, Xingming, Zhu, Mengyuan, Fan, Haiying, Yang, Wenqian, Ni, Weijuan, Karnati, Vishnu V.R., Gao, Shouhai, Carson, John, Weston, Brent, Wang, Binghe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

30

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 31 KB

english, 2015

31

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

File:

PDF, 2.36 MB

2015

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