Volume 25; Issue 15

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Bioorganic & Medicinal Chemistry Letters
Volume 25; Issue 15

Bioorganic & Medicinal Chemistry Letters

Volume 25; Issue 15

1

Structure–activity relationship study of E6 as a novel necroptosis inducer

Mou, Jianfeng, Park, Ann, Cai, Yu, Yuan, Junying, Yuan, Chengye

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 347 KB

english, 2015

2

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Pelcman, Benjamin, Sanin, Andrei, Nilsson, Peter, No, Kiyo, Schaal, Wesley, Öhrman, Sara, Krog-Jensen, Christian, Forsell, Pontus, Hallberg, Anders, Larhed, Mats, Boesen, Thomas, Kromann, Hasse, Vogen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 382 KB

english, 2015

3

Synthesis and antimicrobial evaluation of 5-aryl-1,2,4-triazole-3-thione derivatives containing a rhodanine moiety

Li, Chao, Liu, Jia-Chun, Li, Ya-Ru, Gou, Cheng, Zhang, Mei-Ling, Liu, Hong-Yan, Li, Xiao-Zhen, Zheng, Chang-Ji, Piao, Hu-Ri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 530 KB

english, 2015

4

Synthesis and biological evaluation of curcumin derivatives containing NSAIDs for their anti-inflammatory activity

Liu, Wenfeng, Li, Yonlian, Yue, Yuan, Zhang, Kun, Chen, Qian, Wang, Huaqian, Lu, Yujing, Huang, Mou-Tuan, Zheng, Xi, Du, Zhiyun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.17 MB

english, 2015

5

Use of molecular modeling aided design to dial out hERG liability in adenosine A2A receptor antagonists

Deng, Qiaolin, Lim, Yeon-Hee, Anand, Rajan, Yu, Younong, Kim, Jae-hun, Zhou, Wei, Zheng, Junying, Tempest, Paul, Levorse, Dorothy, Zhang, Xiaoping, Greene, Scott, Mullins, Deborra, Culberson, Chris, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 446 KB

english, 2015

6

Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif

Kino, Ryuto, Araya, Takushi, Arai, Tadamasa, Sohma, Youhei, Kanai, Motomu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 915 KB

english, 2015

7

Design, synthesis and biological evaluation of paralleled Aza resveratrol–chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury

Chen, Wenbo, Ge, Xiangting, Xu, Fengli, Zhang, Yali, Liu, Zhiguo, Pan, Jialing, Song, Jiao, Dai, Yuanrong, Zhou, Jianmin, Feng, Jianpeng, Liang, Guang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

8

Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents

Emmadi, Narender Reddy, Bingi, Chiranjeevi, Kotapalli, Sudha Sravanti, Ummanni, Ramesh, Nanubolu, Jagadeesh Babu, Atmakur, Krishnaiah

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 543 KB

english, 2015

9

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Fauber, Benjamin P., Gobbi, Alberto, Robarge, Kirk, Zhou, Aihe, Barnard, Adrian, Cao, Jianhua, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Ganguli, Arunima, Hawkins, Julie, Johnson, Adam R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 843 KB

english, 2015

10

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Chao, Jianhua, Enyedy, Istvan, Van Vloten, Kurt, Marcotte, Douglas, Guertin, Kevin, Hutchings, Richard, Powell, Noel, Jones, Howard, Bohnert, Tonika, Peng, Chi-Chi, Silvian, Laura, Hong, Victor Sukbon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

11

18F-Fluorodeoxyglucamines: Reductive amination of hydrophilic 18F-fluoro-2-deoxyglucose with lipophilic amines for the development of potential PET imaging agents

Baranwal, Aparna, Mukherjee, Jogeshwar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 724 KB

english, 2015

12

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2

Srinivas, V., Mohan, Chakrabhavi Dhananjaya, Baburajeev, C.P., Rangappa, Shobith, Jagadish, Swamy, Fuchs, Julian E., Sukhorukov, Alexey Yu., Chandra,, Mason, Daniel J., Sharath Kumar, Kothanahally Sh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 819 KB

english, 2015

13

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments

Tintori, Cristina, Esposito, Francesca, Morreale, Francesca, Martini, Riccardo, Tramontano, Enzo, Botta, Maurizio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

14

Recent trends in orexin research—2010 to 2015

Boss, Christoph, Roch, Catherine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

15

Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents

Yadav, Rammohan R., Sharma, Sadhana, Joshi, Prashant, Wani, Abubakar, Vishwakarma, Ram A., Kumar, Ajay, Bharate, Sandip B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 974 KB

english, 2015

16

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists

Nemoto, Toru, Iihara, Yusuke, Hirayama, Shigeto, Iwai, Takashi, Higashi, Eika, Fujii, Hideaki, Nagase, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 475 KB

english, 2015

17

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Wang, Tao, Banerjee, Daliya, Bohnert, Tonika, Chao, Jianhua, Enyedy, Istvan, Fontenot, Jason, Guertin, Kevin, Jones, Howard, Lin, Edward Y., Marcotte, Douglas, Talreja, Tina, Van Vloten, Kurt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.70 MB

english, 2015

18

Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors

Degnan, Andrew P., Tora, George O., Han, Ying, Rajamani, Ramkumar, Bertekap, Robert, Krause, Rudolph, Davis, Carl D., Hu, Joanna, Morgan, Daniel, Taylor, Sarah J., Krause, Kelly, Li, Yu-Wen, Mattson,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

19

Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic properties

Shinoda, Kiyomichi, Sohma, Youhei, Kanai, Motomu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 833 KB

english, 2015

20

Identification of 3,5,6-substituted indolin-2-one’s inhibitors of Aurora B by development of a luminescent kinase assay

Zhang, Leilei, Yang, Tianming, Xie, Xilei, Liu, Gang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 5.73 MB

english, 2015

21

Suppression of CSN5 promotes the apoptosis of gastric cancer cells through regulating p53-related apoptotic pathways

Sang, Miao-Miao, Du, Wen-Qi, Zhang, Rui-Yan, Zheng, Jun-Nian, Pei, Dong-Sheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1024 KB

english, 2015

22

An efficient synthesis and in vitro antibacterial evaluation of ruthenium–quinolinol complexes

Malipeddi, Mahima, Lakhani, Chirag, Chhabra, Mohit, Paira, Priyankar, Vidya, R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 666 KB

english, 2015

23

Pradimicin A, a d-mannose-binding antibiotic, binds pyranosides of l-fucose and l-galactose in a calcium-sensitive manner

Nakagawa, Yu, Watanabe, Yasunori, Igarashi, Yasuhiro, Ito, Yukishige, Ojika, Makoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 583 KB

english, 2015

24

Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease

Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 704 KB

english, 2015

25

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Peters, Hannah L., Jochmans, Dirk, de Wilde, Adriaan H., Posthuma, Clara C., Snijder, Eric J., Neyts, Johan, Seley-Radtke, Katherine L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 423 KB

english, 2015

26

Polymerase incorporation of a 2′-deoxynucleoside-5′-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue

Morihiro, Kunihiko, Hoshino, Hidekazu, Hasegawa, Osamu, Kasahara, Yuuya, Nakajima, Kohsuke, Kuwahara, Masayasu, Tsunoda, Shin-ichi, Obika, Satoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 786 KB

english, 2015

27

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.71 MB

english, 2015

28

New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth.

Suzuki, Mitsuko, Tung, Nguyen Huu, Kwofie, Kofi D., Adegle, Richard, Amoa-Bosompem, Michael, Sakyiamah, Maxwell, Ayertey, Frederick, Owusu, Kofi Baffour-Awuah, Tuffour, Isaac, Atchoglo, Philip, Frempo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 580 KB

english, 2015

29

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase

Pelcman, Benjamin, Sanin, Andrei, Nilsson, Peter, Schaal, Wesley, Olofsson, Kristofer, Krog-Jensen, Christian, Forsell, Pontus, Hallberg, Anders, Larhed, Mats, Boesen, Thomas, Kromann, Hasse, Claesson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.07 MB

english, 2015

30

Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure–activity relationships and bioanalytical studies

Hemmer, Marc, Krawczyk, Sören, Simon, Ina, Hilgeroth, Andreas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 378 KB

english, 2015

31

Synthesis, molecular docking and anticancer studies of peptides and iso-peptides

Jabeen, Farukh, Panda, Siva S., Kondratyuk, Tamara P., Park, Eun-Jung, Pezzuto, John M., Ihsan-ul-haq,, Hall, C. Dennis, Katritzky, Alan R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

32

Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents

Suto, Yutaka, Nakajima-Shimada, Junko, Yamagiwa, Noriyuki, Onizuka, Yoko, Iwasaki, Genji

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 611 KB

english, 2015

33

Alternative synthesis of 3-acetyl, 3-epoxy, and 3-formyl chlorins from a 3-vinyl chlorin, methyl pyropheophorbide-a, via iodination

Oba, Toru, Masuya, Takuto, Yasuda, Satoru, Ito, Satoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 426 KB

english, 2015

34

Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities

Ratnakar Reddy, K., Poornachandra, Y., Jitender Dev, G., Mallareddy, G., Nanubolu, Jagadeesh B., Kumar, C. Ganesh, Narsaiah, B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 554 KB

english, 2015

35

Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors

Park, Suzie, Kim, Han-Shin, Ok, Kiwon, Kim, YunHye, Park, Hee-Deung, Byun, Youngjoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.30 MB

english, 2015

36

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 30 KB

english, 2015

37

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.08 MB

english, 2015

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