Volume 25; Issue 22

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Bioorganic & Medicinal Chemistry Letters
Volume 25; Issue 22

Bioorganic & Medicinal Chemistry Letters

Volume 25; Issue 22

1

Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA

Del Prete, Sonia, Vullo, Daniela, Osman, Sameh M., AlOthman, Zeid, Capasso, Clemente, Supuran, Claudiu T.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 606 KB

english, 2015

2

Inhibitory effects of compounds from Styrax obassia on NO production

Cao, Thao Quyen, Tran, Manh Hung, Kim, Jeong Ah, Tran, Phuong Thao, Lee, Jeong-Hyung, Woo, Mi Hee, Lee, Hyeong-Kyu, Min, Byung Sun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 815 KB

english, 2015

3

Development of a novel tricyclic class of potent and selective FIXa inhibitors

Meng, Dongfang, Andre, Patrick, Bateman, Thomas J., Berger, Richard, Chen, Yi-Heng, Desai, Kunal, Dewnani, Sunita, Ellsworth, Kenneth, Feng, Daming, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 4.08 MB

english, 2015

4

Molecular hybridization yields triazole bronchodilators for the treatment of COPD

Jones, Lyn H., Burrows, Jane, Feeder, Neil, Glossop, Paul, James, Kim, Jones, Rhys M., Kenyon, Amy S., Patel, Sheena, Roberts, Dannielle F., Selby, Matthew D., Strang, Ross S., Stuart, Emilio F., Trev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

5

Liquid scintillators with near infrared emission based on organoboron conjugated polymers

Tanaka, Kazuo, Yanagida, Takayuki, Yamane, Honami, Hirose, Amane, Yoshii, Ryousuke, Chujo, Yoshiki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 422 KB

english, 2015

6

Single excitation three color folded DNA probe for SNP typing

Joo, Han Na, Seo, Young Jun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 652 KB

english, 2015

7

Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization

Youn, Sihyun, Kim, Kyung Im, Ptacek, Jakub, Ok, Kiwon, Novakova, Zora, Kim, YunHye, Koo, JaeHyung, Barinka, Cyril, Byun, Youngjoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1014 KB

english, 2015

8

Novel cycloartane triterpenoids from the Nepal native plant Caragana sukiensis

Mandal, Reeta, Siva, Bandi, Phani Babu, V.S., Suresh Babu, K., Jagadeesh, B., Ranjit, Rosa, Shrestha, Kanti, Gewali, Mohan Bikram

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 588 KB

english, 2015

9

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

10

Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells

Zhang, Cheng-Chen, Yin, Xia, Cao, Chen-Yu, Wei, Jing, Zhang, Qiang, Gao, Jin-Ming

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

11

Synthesis of heterocycle-attached methylidenebenzenesulfonohydrazones as antifungal agents

Gao, Zhinan, Lv, Min, Li, Qin, Xu, Hui

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1001 KB

english, 2015

12

New fluorinated agonists for targeting the sphingosin-1-phosphate receptor 1 (S1P1)

Shaikh, Rizwan S., Keul, Petra, Schäfers, Michael, Levkau, Bodo, Haufe, Günter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 763 KB

english, 2015

13

Synthesis, antimycobacterial and antibacterial activity of l-[(1R,2S)-2-fluorocyclopropyl]naphthyridone derivatives containing an oxime-functionalized pyrrolidine moiety

Huang, Ju, Liu, Hongtao, Liu, Mingliang, Zhang, Rui, Li, Linhu, Wang, Bin, Wang, Minghua, Wang, Chunlan, Lu, Yu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 770 KB

english, 2015

14

Adenosine/guanosine preferring nucleoside ribohydrolase is a distinct, druggable antitrichomonal target

Beck, Sierra, Muellers, Samantha N., Benzie, Annie Laurie, Parkin, David W., Stockman, Brian J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 875 KB

english, 2015

15

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Boy, Kenneth M., Guernon, Jason M., Wu, Yong-Jin, Zhang, Yunhui, Shi, Joe, Zhai, Weixu, Zhu, Shirong, Gerritz, Samuel W., Toyn, Jeremy H., Meredith, Jere E., Barten, Donna M., Burton, Catherine R., Al

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.97 MB

english, 2015

16

Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent

Cao, Jia, Adler, Ben, Perlmutter, Patrick

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 357 KB

english, 2015

17

Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide

Rosa, Mònica, Marcelo, Filipa, Calle, Luis P., Rougeot, Catherine, Jiménez-Barbero, Jesús, Arsequell, Gemma, Valencia, Gregorio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 537 KB

english, 2015

18

Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT2A receptor

Ponnala, Shashikanth, Kapadia, Nirav, Madapa, Sudharshan, Alberts, Ian L., Harding, Wayne W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 825 KB

english, 2015

19

Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cells

Cha, Jin Wook, Lee, Seung Il, Kim, Min Cheol, Thida, Mya, Lee, Jae Wook, Park, Jin-Soo, Kwon, Hak Cheol

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

20

Novel concept of enzyme selective nicotinamide adenine dinucleotide (NAD)-modified inhibitors based on enzyme taxonomy from the diphosphate conformation of NAD

Fujii, Mikio, Kitagawa, Yasuyuki, Iida, Shui, Kato, Keisuke, Ono, Machiko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 726 KB

english, 2015

21

Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages

Eguchi, Keisuke, Kato, Hikaru, Fujiwara, Yukio, Losung, Fitje, Mangindaan, Remy E.P., de Voogd, Nicole J., Takeya, Motohiro, Tsukamoto, Sachiko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 612 KB

english, 2015

22

Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors

Konno, Hiroyuki, Sato, Taki, Saito, Yugo, Sakamoto, Iori, Akaji, Kenichi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.48 MB

english, 2015

23

Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005

Kim, Jong Won, Ko, Sung-Kyun, Son, Sangkeun, Shin, Kee-Sun, Ryoo, In-Ja, Hong, Young-Soo, Oh, Hyuncheol, Hwang, Bang Yeon, Hirota, Hiroshi, Takahashi, Shunji, Kim, Bo Yeon, Osada, Hiroyuki, Jang, Jae-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 574 KB

english, 2015

24

Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists

Dai, Xing, Stamford, Andrew, Liu, Hong, Neustadt, Bernard, Hao, Jingsong, Kowalski, Tim, Hawes, Brian, Xu, Xiaoying, Baker, Hana, O’Neill, Kim, Woods, Morgan, Tang, Huadong, Greenlee, William

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

25

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

Ericson, Mark D., Schnell, Sathya M., Freeman, Katie T., Haskell-Luevano, Carrie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 358 KB

english, 2015

26

Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M1 and M4 muscarinic acetylcholine receptors agonists

Uruno, Yoshiharu, Konishi, Yasuko, Suwa, Atsushi, Takai, Kentaro, Tojo, Kengo, Nakako, Tomokazu, Sakai, Mutsuko, Enomoto, Takeshi, Matsuda, Harumi, Kitamura, Atsushi, Sumiyoshi, Takaaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

27

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Kung, Daniel W., Griffith, David A., Esler, William P., Vajdos, Felix F., Mathiowetz, Alan M., Doran, Shawn D., Amor, Paul A., Bagley, Scott W., Banks, Tereece, Cabral, Shawn, Ford, Kristen, Garcia-Ir

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

28

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

Misawa, Takashi, Yorioka, Momoko, Demizu, Yosuke, Noguchi-Yachide, Tomomi, Ohoka, Nobumichi, Kurashima-Kinoshita, Megumi, Motoyoshi, Hitomi, Nojiri, Hisao, Kittaka, Atsushi, Makishima, Makoto, Naito,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 759 KB

english, 2015

29

New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng

Ma, Li-Yuan, Zhou, Qi-Le, Yang, Xiu-Wei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 548 KB

english, 2015

30

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 30 KB

english, 2015

31

Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors

Stehouwer, Jeffrey S., Bourke, Chase H., Owens, Michael J., Voll, Ronald J., Kilts, Clinton D., Goodman, Mark M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

32

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 7.11 MB

english, 2015