Volume 3; Issue 1

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Bioorganic & Medicinal Chemistry Letters
Volume 3; Issue 1

Bioorganic & Medicinal Chemistry Letters

Volume 3; Issue 1

1

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 426 KB

english, 1993

2

Excitatory amino acid related agents

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 360 KB

english, 1993

3

Synthesis of L-2-(2,3-dicarboxyclopropyl)glycines. Novel conformationally restricted glutamate analogues.

Yasufumi Ohfune, Keiko Shimamoto, Michiko Ishida, Haruhiko Shinozaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 299 KB

english, 1993

4

Competitive NMDA receptor antagonists: synthesis of β-ketophosphonate-substituted piperidine carboxylic acid derivatives

Jeffrey P. Whitten, Rowena V. Cube, Bruce M. Baron, Ian A. McDonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 232 KB

english, 1993

5

Competitive NMDA receptor antagonists; (R)-4-Oxo-5-phosphononorvaline structure-activity relationships

Jeffrey P. Whitten, Bruce M. Baron, Ian A. McDonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 239 KB

english, 1993

6

Enzymatic asymmetric synthesis of (2R, 4R, 5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid, a potent, selective and competitive NMDA antagonist

G.S. Hamilton, Z. Huang, R.J. Patch, B.A. Narayanan, J.W. Ferkany

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 347 KB

english, 1993

7

Pharmacology of (2R, 4R, 5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 17742); a selective, systemically active, competitive NMDA antagonist

J.W. Ferkany, J.S.A. Willetts, D.B. Borosky, E.W. Clissold, Karbon, G.S. Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 408 KB

english, 1993

8

Synthesis and anticonvulsant activity of the (+)- and (−)-enantiomers of 1,2,3,4-tetrahydro-5-(2-phosphonoethyl)-3-isoquinolinecarboxylic acid, a competitive NMDA antagonist

Christopher F. Bigge, Jiang-Ping Wu, Thomas C. Malone, Charles P. Taylor, Mark G. Vartanian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 335 KB

english, 1993

9

Tetrazole amino acids as competitive NMDA antagonists

Paul L. Ornstein, M.Brian Arnold, Debbie Evrard, J.David Leander, David Lodge, Darryle D. Schoepp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 391 KB

english, 1993

10

Synthesis and biological activity of conformationally constrained 4a-phenanthreneamine derivatives as noncompetitive NMDA antagonists

Thomas C. Malone, Daniel F. Ortwine, Graham Johnson, Albert W. Probert Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 404 KB

english, 1993

11

Synthesis and activity of spiroisoindolines as novel noncompetitive NMDA antagonists

Thomas M. Bare, Clyde W. Draper, Charles D. McLaren, Linda M. Pullan, Jitendra Patel, Jitendra B. Patel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 392 KB

english, 1993

12

Anticonvulsant activity of glycine-site NMDA antagonists. 1. 2-carboxyl prodrugs of 5,7-dichlorokynurenic acid

Kevin W. Moore, Paul D. Leeson, Robert W. Carling, Mark D. Ticklebank, Lakhbir Singh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 255 KB

english, 1993

13

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

Robert W. Carling, Paul D. Leeson, Angela M. Moseley, Julian D. Smith, Kay Saywell, Mark D. Tricklebank, John A. Kemp, George R. Marshall, Alan C. Foster, Sarah Grimwood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 448 KB

english, 1993

14

Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor

Paul D. Leeson, Brian J. Williams, Michael Rowley, Kevin W. Moore, Raymond Baker, John A. Kemp, Tony Priestley, Alan C. Foster, Angus E. Donald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 432 KB

english, 1993

15

N-sulfonyl derivatives of 6,7-dichloro 3,4-dihydro-3-oxo-quinoxalinecarboxylate as glycine-site NMDA and AMPA antagonists

Sheryl J. Hays, Peter A. Boxer, Charles P. Taylor, Mark G. Vartanian, Lillian J. Robichaud, Elsebet Ø. Nielsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 323 KB

english, 1993

16

Structure-activity relationships of a series of glycine antagonists related to 5,7-dichlorokynurenic acid and 3-(2-carboxy-6-chloroindol-3-yl)acetic acid

Edward C.R. Smith, Loretta A. McQuaid, David O. Calligaro, Patrick J. O'Malley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 272 KB

english, 1993

17

Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain

Ian J. Reynolds, Kristi D. Rothermund, Sunita Rajdev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 359 KB

english, 1993

18

Oxindole N-Methyl-D-Aspartate (NMDA) antagonists

B.L. Chenard, T.W. Butler, I.A. Shalaby, M.A. Prochniak, B.K. Koe, C.B. Fox

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 269 KB

english, 1993

19

Synthesis and pharmacological characterization of l-trans-4-tetrazolylproline (ly300020): A novel systemically-active ampa receptor agonist

James A. Monn, Matthew J. Valli, Rebecca A. True, Darryl D. Schoepp, J.David Leander, David Lodge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 341 KB

english, 1993

20

Structure-activity relationships of 2,3-benzodiazepine compounds with glutamate antagonistic action

István Tarnawa, Pál Berzsenyi, Ferenc Andrási, Péter Botka, Tamás Hámori, István Ling, Jenö Körösi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 439 KB

english, 1993

21

Isatin oximes - A novel series of bioavailable non-NMDA antagonists

Frank Wätjen, Elsebet Ø. Nielsen, Jørgen Drejer, Leif H. Jensen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 177 KB

english, 1993

22

Enzymatic resolution of AMPA by use of α-chymotrypsin

Birgitte Nielsen, Herdis Fisker, Bjarke Ebert, Ulf Madsen, David R. Curtis, Povl Krogsgaard-Larsen, Jan J. Hansen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 628 KB

english, 1993

23

Conformationally restricted inhibitors of the high affinity L-glutamate transporter

Richard J. Bridges, Frank E. Lovering, John M. Humphrey, Mark S. Stanley, Tracy N. Blakely, Michael F. Cristofaro, A.Richard Chamberlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 3.20 MB

english, 1993