Volume 3; Issue 2

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Bioorganic & Medicinal Chemistry Letters
Volume 3; Issue 2

Bioorganic & Medicinal Chemistry Letters

Volume 3; Issue 2

1

4-hydroxyphenoxymethylene bisphosphonic acid derivatives: potent, non-hydrolysable inhibitors of MYO-inositol monophosphatase

Stephen R. Fletcher, Raymond Baker, Tamara Ladduwahetty, Andrew Sharpe, Martin Teall, John R. Atack

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 290 KB

english, 1993

2

Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents

Jun Qing Guo, Yong Qian Wu, Wayne L. Farmer, Kirk A. Douglas, Patrick M. Woster, Joanne Garofalo, Cyrus J. Basshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 465 KB

english, 1993

3

Conformational preference of N-acyl urea containing valine residue in DMSO d6

R. Jayakumar, Vasantha Pattabhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 238 KB

english, 1993

4

Chemoenzymatic synthesis of optically active α-tocopherol side chain

Kunihiko Takabe, Hiroyuki Sawada, Tetsuo Satani, Takashi Yamada, Takao Katagiri, Hidemi Yoda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 246 KB

english, 1993

5

Efficiency of non-ionic telomeric surfactants for the solubilization of subcellular fractions proteins

Jean C. Maurizis, André A. Pavia, Bernard Pucci

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 302 KB

english, 1993

6

(E) and (Z)5′-fluoro olefin carbocyclic nucleosides: effect of olefin geometry on inhibition of s-adenosyl-l-homocysteine hydrolase

Donald P. Matthews, Michael L. Edwards, Shujaath Mehdi, Jack R. Koehl, Jeffrey A. Wolos, James R. McCarthy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 289 KB

english, 1993

7

A new chromogenic beta-galactosidase substrate based on the redox indicator dye ‘methyl purple’

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 202 KB

english, 1993

8

Resistance of the 2,2,2-trifluoroethoxy aryl moiety to the cytochrome P-450 metabolism in rat liver microsomes

Josep Irurre Jr., Josefina Casas, Angel Messeguer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 315 KB

english, 1993

9

Nucleosides and nucleotides. 117. A transition-state analogue in purine nucleotide biosynthesis: the design and synthesis of an imidazo[4,5-c]azepine nucleoside

Noriaki Minakawa, Takuma Sasaki, Akira Matsuda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 251 KB

english, 1993

10

Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

V.D. Mehta, P.V. Kulkarni, R.P. Mason, P.P. Antich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 422 KB

english, 1993

11

Synthesis of Novel N-substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides

F. Vandendriessche, M. Voortmans, J. Hoogmartens, A. Van Aerschot, P. Herdewijn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 329 KB

english, 1993

12

New TXA2/PGH2 receptor antagonists based on the carbacyclin skeleton

U. Klar, A. Pletsch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 406 KB

english, 1993

13

Synthesis and 5-HT3 receptor agonist activity of arylureas derived from histamine.

J. Bermudez, P. Boyland, F.D. King, R.J. Summersell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 220 KB

english, 1993

14

Synthesis and mechanistic studies of a ‘tetrazole-tethered” cephalosporin-quinolone hybrid

S.L. Dax, D.L. Pruess, P.L. Rossman, C.-c. Wei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 341 KB

english, 1993

15

Novel sigma receptor ligands 1.

S.R. Schow, S.W. Tam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 357 KB

english, 1993

16

Novel sigma receptor ligands 2.

S.R. Schow, S.W. Tam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 234 KB

english, 1993

17

Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimetics

Timothy P. Burkholder, Edward W. Huber, Gary A. Flynn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

18

Synthesis of non-reducing disaccharides. New analogues of trehalosamine constructed from acosamine and ristomine

Ferenc Sztaricskai, Miklós Hornyák, István Komáromi, Gyula batta, István F. Pelyvás

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 321 KB

english, 1993

19

Palladium catalyzed syntheses of phenyl-substittuted pgf2α analogues: potential antigluaucoma agents

Charlotta Liljebris, Bahram Resul, Uli Hacksell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 281 KB

english, 1993

20

K-13 and of4949: Evaluation of key partial structures and pharmacophore delineation

Dale L. Boger, Daniel Yohannes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 372 KB

english, 1993

21

Short and unexpectedly potent difluorostatone type inhibitors of HIV-1 protease

D. Schirlin, S. Baltzer, V. Van Dorsselaer, F. Weber, C. Weill, J.M. Altenburger, B. Neises, G. Flynn, J.M. Rémy, C. Tarnus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 346 KB

english, 1993

22

Substituted N,N′-diphenyl ureas as potent inhibitors of acyl-CoA:Cholesterol acyltransferase (ACAT)

B.K. Trivedi, T.L. Stoeber, R.L. Stanfield, A.D. Essenburg, K.L. Hamelehle, B.R. Krause

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 257 KB

english, 1993

23

Aromatic-aromatic ring interactions tested in cyclophanes

Dong H. Kim, Soo-Suk Lee, Dongmok Whang, Kimoon Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 395 KB

english, 1993

24

Oligodeoxyribonucleotides containing N7-(2-deoxy-β-d-erythro-pentofuranosyl)adenine

Frank Seela, Holger Winter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 261 KB

english, 1993

25

4-Aryltetrahydropyridines as selective σ ligands

David J. Wustrow, Lawrence D. Wise, Thomas A. Pugsley, Leonard T. Meltzer, Thomas G. Heffner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 251 KB

english, 1993

26

Semisynthetic modification of hygromycin A. 2. synthesis and antibacterial activity of aryl analogs.

Scott J. Hecker, Christopher B. Cooper, Kyle T. Blair, Susan C. Lilley, Martha L. Minich, Kim M. Werner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 455 KB

english, 1993

27

Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists

Paul D. Leeson, Raymond Baker, Robert W. Carling, Janusz J. Kulagowski, Ian M. Mawer, Mark P. Ridgill, Michael Rowley, Julian D. Smith, Ian Stansfield, Graeme I. Stevenson, Alan C. Foster, John A. Kem

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 390 KB

english, 1993

28

Synthesis of new amide-linked N-hydroxyurea 5-lipoxygenase inhibitors by an intramolecular oxygen to nitrogen acyl transfer

Joseph F. Dellaria Jr., Kevin J. Sallin, Karen Rodriques

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 293 KB

english, 1993

29

Phosphonates and thiophosphonates as sulfate surrogates: synthesis of estrone 3-methylthiophosphonate, a potent inhibitor of estrone sulfatase

Nicola M Howarth, Gary Cooper, Atul Purohit, Lorna Duncan, Michael J Reed, Barry VL Potter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 337 KB

english, 1993

30

A facile synthesis of the novel Neurokinin A antagonist SR 48968

Jeffrey J. Hale, Paul E. Finke, Malcolm MacCoss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 261 KB

english, 1993

31

Quantitative structure -actvity relationship studies of aromatic and heteroaromatic nitro compounds using neural network

Nanda Ghoshal, Sudhindra N. Mukhopadhyay, Tapan K. Ghoshal, Basudeb Achari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 202 KB

english, 1993

32

Design and synthesis of a DNA-cleaving metallopeptide

Daniel F. Shullenberger, Eric C. Long

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 303 KB

english, 1993

33

Potent, non-peptidic oxytocin receptor antagonists from a natural source

Gino M. Salituro, Douglas J. Pettibone, Bradley V. Clineschmidt, Joanne M. Williamson, Deborah L. Zink

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 263 KB

english, 1993

34

Chemistry of the new immunosuppressant KH-1060: new synthons and x-ray evidence for unique side-chain geometry

Stephen R. Wilson, Hong Zhao, John Dewan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 244 KB

english, 1993

35

Identification of a new fluorescent compound isolated from human lens insoluble protein fraction

Amane Inoue, Kenshi Satoh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 151 KB

english, 1993

36

Solid phase synthesis of DNA containing 5-NH2-2′-deoxyuridine

Dinesh A Barawkar, K.N. Ganesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 357 KB

english, 1993

37

Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase

Robert K. Griffith, Richard A. DiPietro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 243 KB

english, 1993

38

High-purity porcine pancreatic lipase: novel effects in catalyzing hydrolysis of esters derived from bicyclo[3.2.0]hept-2-EN-6-OLS

Omar Parve, Anne Pals, Vello Kadarpik, Ülo Lille, Peeter Sikk, Aivar Löokene, Toomas Välimäe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 145 KB

english, 1993

39

Enantioselective preparation of novel bicyclo[3.2.0]heptane derivatives using ester hydrolysis catalyzed by novo lipolaseTM

Omar Parve, Anne Pals, Vello Kadarpik, Lilja Lahe, Ülo Lille, Peeter Sikk, Aivar Lóokene, Välimäe Toomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 299 KB

english, 1993

40

Novel results on the biocyclisation of 2,3-oxidosqualene analogs by sterol cyclase

Alain Krief, Patrick Pasau, Eric Guittet, Yang Yin Shan, Marc Herin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 364 KB

english, 1993

41

Substituted pyrrolidin-2-one biphenyltetrazoles as angiotensin II antagonists

W.V. Murray, P. Lalan, A. Gill, M.F. Addo, J.M. Lewis, D.K.H. Lee, M.P. Wachter, R. Rampulla, D.C. Underwood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 363 KB

english, 1993

42

Announcements

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 94 KB

english, 1993

43

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 923 KB

english, 1993

44

The synthesis and anti-hiv activity of pyrimidine dioxolanyl nucleosides

Lawrence J. Wilson, Woo-Baeg Choi, Travis Spurling, Dennis C. Liotta, Raymond F. Schinazi, Deborah Cannon, George R. Painter, Marty St. Clair, Phillip A. Furman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 448 KB

english, 1993

45

DNA gyrase inhibitory and antibacterial activity of some flavones(1)

K.A. Ohemeng, C.F. Schwender, K.P. Fu, J.F. Barrett

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 356 KB

english, 1993

46

Monocyclization of N-(2,2-diethoxyethyl)-1,2-diphenylethylamines to the 4-aryl-hydroxy-2,3,4,5-tetrahydro-iH-3-benzazepine ring system

Kyle R. Gee, Eckard Weber, John F.W. Keana

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 166 KB

english, 1993

47

Preparation of the enantiomers of the analgesic E-3710.

Juan A. Hueso-Rodríguez, Joana Berrocal, Bonifacio Gutiérrez, Antonio J. Farré, Jordi Frigola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 285 KB

english, 1993

48

An NMR method for elucidating the stereochemistry of protein farnesylation

Richard A. Gibbs, Yong Qi Mu, Fang Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 301 KB

english, 1993

49

Probing a catalytic antibody active site using spin-labelled haptens

Paul S. Skerker, Jeffrey W. Jacobs, Douglas S. Clark, Peter G. Schultz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 254 KB

english, 1993

50

Application of hygromycin a structure activity relationships to the antibiotic A201A.

Scott J. Hecker, Susan C. Lilley, Martha L. Minich, Kim M. Werner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 262 KB

english, 1993

51

Phenylphosphonate monoester analogs of cocaine. Potential haptens for the generation of catalytic antibodies

Nizal S. Chandrakumar, Christopher P. Carron, Debra M. Meyer, Patrick M. Beardsley, Susan A. Nash, Linda L. Tam, Michael Rafferty

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 278 KB

english, 1993

52

Synthesis and release of doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate

Thomas W. Hudyma, Karen Bush, Kimberly L. Colson, Raymond A. Firestone, H.Dalton King

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 346 KB

english, 1993

53

Silver selective pyridine based diamide-diester 18-membered macrocycle- Syntheis and ionophore character

Subodh Kumar, Rajinder Singh, Karjit Singh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 128 KB

english, 1993

54

1,3- And 1,5-bisbiphenylyl substituted 3-metcaptotriazoles as angiotensin II receptor antagonists

V.T. Bandurco, W.V. Murray, A. Gill, M. Addo, J. Lewis, M.P. Wachter, S. Hadden, D.C. Underwood, W.-M. Cheung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 256 KB

english, 1993

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