Volume 3; Issue 5

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Bioorganic & Medicinal Chemistry Letters
Volume 3; Issue 5

Bioorganic & Medicinal Chemistry Letters

Volume 3; Issue 5

1

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 647 KB

english, 1993

2

Foreword

David C. Horwell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 64 KB

english, 1993

3

The design of a dipeptide library for screening at peptide receptor sites

David C. Horwell, William Howson, Giles S. Ratcliffe, David C. Rees

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 321 KB

english, 1993

4

The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics

Ute Gerhard, Mark S. Searle, Dudley H. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 456 KB

english, 1993

5

Protection of the peptide bond against α-chymotrypsin by the prodrug approach

Anne H. Kahns, Gitte J. Friis, Hans Bundgaard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 257 KB

english, 1993

6

Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs

H. Hamilton, B. Steinbaugh, J. Blankley, M. Taylor, O.H. Chan, B. Stewart, R. Schroeder, M. Ryan, S. Rapundalo, J. Cook, A. Bernabei, C. Stewart

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 313 KB

english, 1993

7

Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties

T.K. Sawyer, J.F. Fisher, J.B. Hester, C.W. Smith, A.G. Tomasselli, W.G. Tarpley, P.S. Burton, J.O. Hui, T.J. McQuade, R.A. Conradi, V.S. Bradford, L. Liu, J.H. Kinner, J. Tustin, D.L. Alexander, A.W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 497 KB

english, 1993

8

Gem-cycloalkyl substituted thiol inhibitors of neutral endopeptidase 24.11. Synthesis via nucleophilic opening of 2,2-spiro-β-lactones

Keith James, Michael J. Palmer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 417 KB

english, 1993

9

A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin

Maria K. Hristova-Kazmierski, P. Horan, P. Davis, H.I. Yamamura, T. Kramer, R. Horvath, W.M. Kazmierski, F. Porreca, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 246 KB

english, 1993

10

Nonpeptide β-turn mimetics of enkephalin

Ting Su, Hiroshi Nakanishi, Liang Xue, Barbara Chen, Sudersan Tuladhar, Michael E. Johnson, Michael Kahn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 467 KB

english, 1993

11

Structure-based design and pharmacological properties of potent selective and systemically active CCK-B peptidomimetics

Bernard P. Roques, Pierre-Jean Corringer, Muriel Derrien, Valérie Daugé, Christiane Durieux

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 308 KB

english, 1993

12

On the significance of the C-terminal primary amide in cholecystokinin

Marc Rolland, Marie-Françoise Lignon, Marie-Christine Galas, Nicole Bernad, Marc Rodriguez, Pierre Fulcrand, Jean Martinez

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 353 KB

english, 1993

13

Toward developing peptidomimetics: Successful replacement of backbone amide bonds in tetrapeptide-based CCK-A receptor agonists

Kazumi Shiosaki, Chun Wel Lin, M.Robert Leanna, Howard E. Morton, Thomas R. Miller, David Witte, Michael Stashko, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 456 KB

english, 1993

14

Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists

Francesco Makovec, Laura Mennuni, Walter Peris, Laura Revel, Lucio C. Rovati

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 422 KB

english, 1993

15

Multipurpose receptor ligands: β-carboline cholecystokinin antagonists

Ben E. Evans, Kenneth E. Rittle, Raymond S.L. Chang, Victor J. Lotti, Stephen B. Freedman, Roger M. Freidinger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 312 KB

english, 1993

16

Benzolactams as non-peptide cholecystokinin receptor ligands

Mark G. Bock, Robert M. DiPardo, Daniel F. Veber, Raymond S.L. Chang, Victor J. Lotti, Stephen B. Freedman, Roger M. Freidinger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 326 KB

english, 1993

17

Diphenylpyrazolidinone and benzodiazepine cholecystokinin antagonists: A case of convergent evolution in medicinal chemistry

J.Jeffry Howbert, Karen L. Lobb, Thomas C. Britton, Norman R. Mason, Robert F. Bruns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 494 KB

english, 1993

18

Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class

M. Higginbottom, D.C. Horwell, E. Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 268 KB

english, 1993

19

Synthesis of a potent and selective non-peptide CCK-B/gastrin receptor antagonist tritiated ligand.

D. Hill, D.C. Horwell, J.C. Hunter, C.O. Kneen, M.C. Pritchard, N. Suman-Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 228 KB

english, 1993

20

The rational design and synthesis of non-peptide ‘rhegnylogues” of CCK-26-33 - a novel series of CCK-A selective ligands

G.T. Bourne, D.C. Horwell, M.C. Pritchard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 404 KB

english, 1993

21

The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists

David J. Carini, Andrew T. Chiu, Pancras C. Wong, Alexander L. Johnson, Ruth R. Wexler, Pieter B.M.W.M. Timmermans

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 280 KB

english, 1993

22

Quinoline, 1,5-naphthyridine and pyridine derivatives as potent, nonpeptidic angiotensin II receptor antagonists

C.P. Allott, R.H. Bradbury, M. Dennis, E. Fisher, R.W.A. Luke, J.S. Major, A.A. Oldham, R.J. Pearce, A.C. Reid, D.A. Roberts, D.A. Rudge, S.T. Russell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 495 KB

english, 1993

23

The syntheses and binding affinities of tools for the study of angiotensin AT2 receptors

John C. Hodges, Jeremy J. Edmunds, Gerald D. Nordblom, Gina H. Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 262 KB

english, 1993

24

Refinement of a molecular model of angiotensin II (AII) employed in the discovery of potent nonpeptide antagonists

James M. Samanen, Catherine E. Peishoff, Richard M. Keenan, Joseph Weinstock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 400 KB

english, 1993

25

Peptide azoles: A new class of biologically-active dipeptide mmetics.

Tom Gordon, Philip Hansen, Barry Morgan, Jasbir Singh, Eugene Baizman, Susan Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 406 KB

english, 1993

26

Nuclear variations of quinuclidine substance P antagonists: 2-diphenylmethyl-1-azabicyclo[3.2.2]nonan-3-amines

John A. Lowe III, Susan E. Drozda, R.Michael Snider, Kelly P. Longo, James P. Rizzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 247 KB

english, 1993

27

Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor

Xavier Emonds-Alt, Vincenzo Proietto, Didier Van Broeck, Pol Vilain, Charles Advenier, Gervais Neliat, Gérard Le Fur, Jean-Claude Brelère

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 359 KB

english, 1993

28

Low molecular weight neurokinin NK2 antagonists

P.W. Smith, A.B. McElroy, J.M. Pritchard, M.j. Deal, G.B. Ewan, R.M. Hagan, S.j. Ireland, D. Ball, I. Beresford, R. Sheldrick, C.C. Jordan, P. Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 377 KB

english, 1993

29

Novel Y2-selective, reduced-size agonists of neuropeptide Y

Annette G. Beck-Sickinger, Eike Hoffmann, Wolfram Gaida, Eric Grouzmann, Hansjörg Dürr, Günther Jung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 398 KB

english, 1993

30

Antagonists of luteinising hormone-releasing hormone (LHRH). Progress towards non-peptide leads

A.S. Dutta, J.J. Gormley, J.R. Woodburn, P.K.C. Paul, D.J. Osguthorpe, M.M. Campbell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 426 KB

english, 1993

31

A structure-affinity study of the amino acid side-chains in neurotensin : N and C terminal deletions and Ala-scan

Jenny A. Henry, David C. Horwell, Kenneth G. Meecham, David C. Rees

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 331 KB

english, 1993

32

Backbone modified formyl-methionyl tripeptide chemoattractants

F. Formaggio, M. Pantano, M. Crisma, C. Toniolo, W.H.J. Boesten, H.E. Schoemaker, J. Kamphuis, E.L. Becker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 304 KB

english, 1993

33

The design and synthesis of kappa opioid ligands based on a binding model for kappa agonists

Michael Higginbottom, William Nolan, John O'Toole, Giles S. Ratcliffe, David C. Rees, Edward Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 349 KB

english, 1993