Volume 3; Issue 8

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Bioorganic & Medicinal Chemistry Letters
Volume 3; Issue 8

Bioorganic & Medicinal Chemistry Letters

Volume 3; Issue 8

1

Announcements

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 199 KB

english, 1993

2

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 1.06 MB

english, 1993

3

Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations

Peter Gmeiner, Josef Sommer, Joachim Mierau, Georg Höfner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 2.79 MB

english, 1993

4

The design and synthesis of novel hydroxyproline inhibitors of HIV-1 proteinase

Duncan S. Holmes, Richard C. Bethell, Michael M. Hann, John Kitchin, Ian D. Starkey, Richard Storer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 2.64 MB

english, 1993

5

Cyclic ether acetal platelet activating factor (PAF) receptor antagonists I: 3-pyridyl derivatives

Mark Whittaker, Timothy M. Thompson, Zoë M. Spavold, Michael Price, Andrew Miller, W.Alan Galloway, Fiona Fraser, Christopher D. Floyd, Alan H. Drummond, Alan H. Davidson, Stephen A. Bowles, Deborah S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 474 KB

english, 1993

6

Cyclic ether acetal platelet activating factor (PAF) receptor antagonists II: imidazo[4,5-c]pyridyl derivatives

L.Michael Wood, Mark Whittaker, David J. Timmis, Timothy M. Thompson, Lydia Saroglou, Andrew Miller, Alan H. Davidson, Mark S. Christodoulou, Karen S. Cackett, Stephen A. Bowles, Deborah S. Bebbington

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 403 KB

english, 1993

7

Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

Stephen J Mills, Stephen T Safrany, Robert A Wilcox, Stefan R Nahorski, Barry VL Potter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 343 KB

english, 1993

8

2-NAP: a selective, hydrophilic, non-peptide CCKA - receptor antagonist derived from the cholecystokinin C-terminal dipeptide.

Iain M. McDonald, Michael J. Bodkin, Howard B. Broughton, David J. Dunstone, S.Barret Kalindjian, Caroline M.R. Low

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 444 KB

english, 1993

9

A new structural analogue antagonist of peptido-leukotrienes. The discovery of bay x7195

T.S. Abram, H. Böshagen, J.E. Butler, N.J. Cuthbert, H.P. Francis, P.J. Gardiner, W. Hartwig, H.C. Kluender, P. Norman, H. Meier, U. Rosentreter, K.H. Schlemmer, S.R. Tudhope, W.A. Taylor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 420 KB

english, 1993

10

A highly efficient synthesis of RWJ 47639: a novel orally active angiotensin II receptor antagonist.

Jeffrey D. Hsi, William V. Murray, Alan Gill

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 282 KB

english, 1993

11

On the function of the 2′-hydroxyl group in the peptidyl tRNA terminus during elongation in ribosomal peptide biosynthesis

Stanley I. Goldberg, Xing-Ping Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 270 KB

english, 1993

12

Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position

Burton H. Jaynes, Christopher B. Cooper, Scott J. Hecker, Kyle T. Blair, Nancy C. Elliott, Susan C. Lilley, Martha L. Minich, Douglas L. Schicho, Kim M. Werner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 462 KB

english, 1993

13

Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.

Stuart W McCombie, Robert W Bishop, Donna Carr, Emily Dobek, Michael P Kirkup, Paul Kirschmeier, Sue-Ing Lin, Joanne Petrin, Karen Rosinski, Bandarpalle B Shankar, Oswald Wilson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 490 KB

english, 1993

14

Antiviral optically pure dioxolane purine nucleosides analogues

M.Arshad Siddiqui, William L. Brown, Nghe Nguyen-Ba, Dilip M. Dixit, Tarek S. Mansour, Elizabeth Hooker, K.Claire Viner, Janet M. Cameron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 266 KB

english, 1993

15

Synthesis of phosphodiester and triester derivatives of AZT with tethered N-methyl piperazine and N,N,N′ trimethylethylenediamine.

Carole Desseaux, Tam Huynh-Dinh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 303 KB

english, 1993

16

Synthesis and antiflammatory activity of some 3-heterocycle-1,2-benzisothiazoles

Shanti N. Sawhney, Pawan K. Sharma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 256 KB

english, 1993

17

Derivatives of quinuclidine as 5-HT3 receptor antagonists: influence of an additional carbonyl group on the recognition of chirality by the receptor.

M. Langlois, J.L. Soulier, M. Allainmat, S. Shen, C. Gallais

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 372 KB

english, 1993

18

4,5,6,7-Tetrahdryo-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiiotensin II receptor antagonists

Takashi Yanagisawa, Naoto Ueyama, Tomoyuki Kawai, Motoharu Sonegawa, Hiromi Baba, Seiichiro Mochizuki, Kazukiro Kozakai, Tsuyoshi Tomiyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 386 KB

english, 1993

19

Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsins

Guojian Xie, A.Richard Morgan, J.William Lown

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 400 KB

english, 1993

20

(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase

Choung Un Kim, Peter F. Misco, Bing Y. Luh, Brian Terry, Gregory Bisacchi, Muzammil M. Mansuri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 300 KB

english, 1993

21

Stereochemistry of the KDO8P synthase. An efficient synthesis of the 3-fluoro analogues of KDO8P

Amnon Kohen, Ronit Berkovich, Valery Belakhov, Timor Baasov

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 489 KB

english, 1993

22

Insight into the catalytic mechanism of KDO8P synthase. Synthesis and evaluation of the isosteric phosphonate mimic of the putative cyclic intermediate

Shani Sheffer-Dee-Noor, Valery Belakhov, Timor Baasov

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 476 KB

english, 1993

23

Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitors

Robert E. Babine, Nan Zhang, Steven R. Schow, Michael R. Jirousek, Bernard D. Johnson, Suresh S. Kerwar, Parimal R. Desai, Randal A. Byrn, Richard C. Hastings, Michael M. Wick

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 374 KB

english, 1993

24

Synthesis and biological evaluation of a series of HIV-1 protease inhibitors

Michael P. Trova, Robert E. Babine, Randal A. Byrn, Wellington T. Casscles Jr., Richard C. Hastings, Grace C. Hsu, Michael R. Jirousek, Bernard D. Johnson, Suresh S. Kerwar, Steven R. Schow, Allan Wis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 476 KB

english, 1993

25

Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases

Carlos García-Echeverría, Daniel H. Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 324 KB

english, 1993

26

A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase

C.Nicholas Hodge, John Pierce

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 304 KB

english, 1993

27

A concise enantioselective synthesis of rans-olefin dipeptide isosteres

Richard Beresis, James S. Panek

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 487 KB

english, 1993

28

A combined chemical-enzymatic synthesis of a new phosphoramidate analogue of phosphoenolpyruvate

Shani Sheffer-Dee-Noor, Timor Baasov

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 345 KB

english, 1993

29

Synthesis and biological activity of 3′,4′,5′-trihydroxy etoposide

Mark G. Saulnier, Karen L. LeBoulluec, Danny P.C. McGee, Byron H. Long, Alfred R. Crosswell, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 379 KB

english, 1993

30

Hypoglycaemic activity of an analogue of human growth hormone [6-13] incorporating a d-ala-pro dipeptide unit

Philip E. Thompson, Noel Lim, Effendi Wijaya, Frank M. Ng, Milton T.W. Hearn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 252 KB

english, 1993

31

Synthesis of a biologically active chlorinated analog of (E,E)-8,10- dodecadienol (codlemone)

Frédérique Tellier, Abdelhay Hammoud, Victoria Ratovelomanana, Gérard Linstrumelle, Charles Descoins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 252 KB

english, 1993

32

Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonist

Kenji Otsubo, Seiji Morita, Minoru Uchida

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 245 KB

english, 1993

33

Hydride transfer versus electron transfer in the baker's yeast reduction of α-haloacetophenones

Luis M. Aleixo, Márcia de Carvalho, Paulo José Samenho Moran, J.Augusto R. Rodrigues

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 358 KB

english, 1993

34

Investigation of the conformation, solubility, structure and selectivity of alkaline proteases in anhydrous alcohols.

Shui-Tein Chen, Shiah-Yun Chen, Chen-Chen Tu, Kung-Tsung Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 452 KB

english, 1993

35

Excitatory amino acid receptor atagonists: synthesis and pharmacology of 3-(carboxymethoxy)isoxazoles derived from AMPA

U. Madsen, L. Andresen, G.A. Poulsen, T.B. Rasmussen, B. Ebert, P. Krogsgaard-Larsen, L. Brehm

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 566 KB

english, 1993

36

The effect of aryl fluorines in a lipase resolution.

Lakkaraju Dasaradhi, David O'Hagan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 286 KB

english, 1993

37

Structure-activity relationships of 6-substituted benzopyran-4-carbothioamide potassium channel openers

Takenori Ishizawa, Hiroshi Koga, Masateru Ohta, Haruhiko Sato, Toshihiko Makino, Kiyonori Kuromaru, Naoki Taka, Tadakatsu Takahashi, Tsutomu Sato, Hiroyuki Nabata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 320 KB

english, 1993

38

Synthesis and cardiotonic activity of 2,9-dihydro-6-(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)pyrazolo[4,3-b][1,4]benzoxazine

Donald W. Combs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 230 KB

english, 1993

39

Conformation of the CYP2D6 model substrate sparteine under physiological conditions

Frank Schneider, Peter Fischer, Thomas Ebner, Claus O. Meese

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 330 KB

english, 1993

40

Transfecting activity of photoirradiated φx 174 DNA in the presence of hydroperoxynaphthalimides

Seiichi Matsugo, Ken-ichi Kodaira, Isao Saito

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 270 KB

english, 1993

41

Fibrinogen receptor antagonists containing a gamma-lactam Gly-Asp isostere

Georg Kottirsch, Carlo Tapparelli, Hans-Günther Zerwes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 383 KB

english, 1993

42

Synthesis of a potential photoaffinity labelling reagent for HIV-1 reverse transcriptase

Hiromichi Tanaka, Masanori Baba, Tomomi Yamamoto, Shuichi Mori, Richard T. Walker, Erik De Clercq, Tadashi Miyasaka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 358 KB

english, 1993

43

Role of sulfonamide moiety in non-prostanoid txa2 receptor antagonist kt2-962 : modifications of this moiety and the resulting activities

Masayuki Yokota, Kenji Imamaki, Satoko Uchibori, Masahiro Kondo, Kazuhiro Kosakai, Tsuyoshi Tomiyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 392 KB

english, 1993

44

Angiotensin II receptor antagonists containing a phenylpyridine element.

Nathan.B. Mantlo, Raymond S.L. Chang, Peter.K.S. Siegl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 340 KB

english, 1993

45

Targeting radiosensitizers to DNA by minor groove binding: nitroarenes based on netropsin and distamycin

John Parrick, Manuchehr Porssa, Lisa K. Davies, Madeleine F. Dennis, Kantilal B. Patel, Michael R.L. Stratford, Peter Wardman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 437 KB

english, 1993

46

Quinuclidine based NK-1 antagonists 2: determination of the absolute stereochemical requirements

C.J. Swain, E.M. Seward, V. Sabin, S. Owen, R. Baker, M.A. Cascieri, S. Sadowski, C. Strader, R.G. Ball

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 281 KB

english, 1993

47

Synthesis and antimalarial evaluation of 2,3,5-trioxabicyclo[2.2.3]nonane, a model for the putative pharmacophore of artemisinin

Dee Ann Casteel, S.Prasad Peri, Lucia Gerena

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 301 KB

english, 1993

48

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Mark P. Wentland, George Y. Lesher, Michael Reuman, Garry M. Pilling, Manohar T. Saindane, Robert B. Perni, Michael A. Eissenstat, John D. Weaver III, Baldev Singh, James Rake, Susan A. Coughlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 416 KB

english, 1993

49

Synthesis and biological activity of sulfoximine-modified myristic acid analogues

Ian A. McDonald, Philip L. Nyce, George S. Ku, Terry L. Bowlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 344 KB

english, 1993

50

A novel class of 1,3-oxathiolane nucleoside analogues having potent anti-HIV activity

Bernard Belleau, Livio Brasili, Laval Chan, Marika P. DiMarco, Boulos Zacharie, Nghe Nguyen-Ba, Helen J. Jenkinson, Jonathan A.V. Coates, Janet M. Cameron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 427 KB

english, 1993

51

Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors

Paul C. Unangst, David T. Connor, Wiaczeslaw A. Cetenko, Roderick J. Sorenson, Jagadish C. Sircar, Clifford D. Wright, Denis J. Schrier, Richard D. Dyer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 307 KB

english, 1993

52

Synthesis and evaluation of 3-carboxymethyl steroids as inhibitors of human prostatic steroid 5α-reductase

Dennis A. Holt, Hye-Ja Oh, Leonard W. Rozamus, Hwa-Kwo Yen, Martin Brandt, Mark A. Levy, Metcalf Brian W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 321 KB

english, 1993

53

Design and synthesis of cosalane, a novel anti-HIV agent

W.Marek Golebiewski, John P. Bader, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 332 KB

english, 1993

54

The selective inhibition of phosphodiesterase IV by benzopyran derivatives of rolipram

I.L. Pinto, D.R. Buckle, S.A. Readshaw, D.G. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 301 KB

english, 1993

55

A new galactosyl transferase inhibitor

Richard R. Schmidt, Klaus Frische

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 294 KB

english, 1993

56

Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers

Liren Huang, A.Richard Morgan, J.William Lown

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 465 KB

english, 1993

57

Semisynthesis of Linear Fragments Corresponding to the Eastern Portion of Azalide Antibiotics

Sherman T. Waddell, Timothy A. Blizzard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 284 KB

english, 1993

58

Novel water soluble phosphate prodrugs of taxol® possessing in vivo antitumor activity

Yasutsugu Ueda, Amarendra B. Mikkilineni, Jay O. Knipe, William C. Rose, Anna Maria Casazza, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 453 KB

english, 1993

59

Identification of simpler analogs of neurotensin(9–13) which retain antinociceptive activity

Gary A. Cain, Thomas E. Christos, Alexander L. Johnson, Richard S. Pottorf, S.William Tam, William K. Schmidt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 397 KB

english, 1993

60

Additions and Corrections

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

File:

PDF, 32 KB

1993

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