Volume 30; Issue 21

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Bioorganic & Medicinal Chemistry Letters
Volume 30; Issue 21

Bioorganic & Medicinal Chemistry Letters

Volume 30; Issue 21

1

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Hu, Zilun, Wang, Cailan, Sitkoff, Doree, Cheadle, Nathan L., Xu, Songmei, Muckelbauer, Jodi K., Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 978 KB

2020

2

Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs

Bieszczad, Bartosz, Siwek, Agata, Wilczek, Marcin, TrzybiÅski, Damian, WoÅºniak, Krzysztof, SataÅa, Grzegorz, Bojarski, Andrzej J., Mieczkowski, Adam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.09 MB

2020

3

Synthesis and biological evaluation of thiazole derivatives on basic defects underlying cystic fibrosis

Pesce, Emanuela, Pedemonte, Nicoletta, Leoni, Alberto, Locatelli, Alessandra, Morigi, Rita

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 634 KB

2020

4

Isolation, reactivity, pharmacological activities and total synthesis of hispanolone and structurally related diterpenes from Labiatae plants

Marco, JosÃ© L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 967 KB

2020

5

New lead discovery of insect growth regulators based on the scaffold hopping strategy

Jiang, Biaobiao, Guo, Bingbo, Cui, Jialin, Dong, Yawen, Cui, Li, Zhang, Li, Yang, Qing, Yang, Xinling

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.66 MB

2020

6

Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimerâs disease

Blaikie, Laura, Kay, Graeme, Kong Thoo Lin, Paul

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.20 MB

2020

7

Highly regioselective biotransformation of ginsenoside Rg1 to 25-OH derivatives of 20(S/R)-Rh1 by Cordyceps Sinensis

Sui, Xin, Liu, Jishuang, Xin, Yu, Qu, Mo, Qiu, Ye, He, Tianzhu, Luo, Haoming, Wang, Weinan, Qiu, Zhidong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.84 MB

2020

8

Synthesis of flutamide-conjugates

Medina-Rojas, Julio CÃ©sar, Castillo-RodrÃguez, Irving Osiel, MartÃnez-Klimova, Elena, RamÃrez-Ãpan, Teresa, HernÃ¡ndez-Ortega, SimÃ³n, MartÃnez-GarcÃa, Marcos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 781 KB

2020

9

Synthesis and biological evaluation of semi-synthetic albocycline analogs

Daher, Samer S., Franklin, Kevin P., Scherzi, Tyler, Dunman, Paul M., Andrade, Rodrigo B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 610 KB

2020

10

Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT2B receptor antagonist scaffold

Kim, Minsoo, Truss, Myles, Pagare, Piyusha P., Essandoh, Martha A., Zhang, Yan, Williams, Dwight A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.14 MB

2020

11

Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH)

Chen, Zhen, Hou, Lu, Gan, Jiefeng, Cai, Qijun, Ye, Weijian, Chen, Jiahui, Tan, Zhiqiang, Zheng, Chao, Li, Guocong, Xu, Hao, Fowler, Christopher J., Liang, Steven H., Wang, Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.71 MB

2020

12

Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors

Patel, Manoj, Cianci, Christopher, Allard, Christopher W., Parker, Dawn D., Simmermacher, Jean, Jenkins, Susan, Mcauliffe, Brian, Minassian, Beatrice, Discotto, Linda, Krystal, Mark, Meanwell, Nichola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.46 MB

2020

13

Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947

Brockunier, Linda, Stelmach, John, Guo, Jian, Spencer, Tracy, Rosauer, Keith, Bansal, Alka, Cai, Sheng-Jian, Chen, Nancy, Cummings, John, Huang, Li, Johnson, Timothy, Levesque, Sonia, Luo, Lin, Malone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 466 KB

2020

14

Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors

Yang, Yajun, Wang, Ke, Wu, Bo, Yang, Ying, Lai, Fangfang, Chen, Xiaoguang, Xiao, Zhiyan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.03 MB

2020

15

Editorial Board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.14 MB

2020

16

Graphical Abstract Contents Continued

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 182 KB

2020

17

Effects on anti-inflammatory, DNA binding and molecular docking properties of 2-chloroquinolin-3-yl-methylene-pyridine/pyrazole derivatives and their palladium(II) complexes

Bhuvaneswari, S., Umadevi, M., Vanajothi, R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.38 MB

2020

18

Graphical abstract TOC

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 56 KB

2020

19

Graphical abstract TOC

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 26 KB

2020

20

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Reed, Anthony B., Lanman, Brian A., Holder, Jerry Ryan, Yang, Bryant H., Ma, Ji, Humphreys, Sara C., Wang, Zhican, Chan, Joyce C.Y., Miranda, Les P., Swaminath, Gayathri, Allen, John G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.01 MB

2020

21

Antimalarial activity of tetrahydro-Î²-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein

Eagon, Scott, Hammill, Jared T., Bach, Jordan, Everson, Nikalet, Sisley, Tyler A., Walls, Michael J., Durham, Sierra, Pillai, Dylan R., Falade, Mofolusho O., Rice, Amy L., Kimball, Joshua J., Lazaro,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 3.25 MB

2020

22

Novel carboxylated pyrroline-2-one derivatives bearing a phenylhydrazine moiety: Design, synthesis, antifungal evaluation and 3D-QSAR analysis

Chen, Min, Zhang, Lizhi, Lu, Aimin, Wang, Xiaobin, Si, Weijie, Yan, Jinghua, Yang, Chunlong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 4.23 MB

2020

23

Overcoming Î²-Lactam resistance in Pseudomonas aeruginosa using non-canonical tobramycin-based antibiotic adjuvants

Idowu, Temilolu, Ammeter, Derek, Brizuela, Marc, Jackson, Gregory, Alam, Shadman, Schweizer, Frank

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 778 KB

2020

24

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor

Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Horiguchi, Masakuni, Isobe, Yoshiaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 508 KB

2020

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