Volume 7; Issue 1

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Bioorganic & Medicinal Chemistry Letters
Volume 7; Issue 1

Bioorganic & Medicinal Chemistry Letters

Volume 7; Issue 1

1

The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)

David O Calligaro, John Fairhurst, Terrence M Hotten, Nicholas A Moore, David E Tupper

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 320 KB

english, 1997

2

Bis-quinolinium cyclophanes: A novel class of potent blockers of the apamin-sensitive Ca2+-activated K+ channel

Joaquin Campos Rosa, Bridgitte M Beckwith-Hall, Dimitrios Galanakis, C.Robin Ganellin, Philip M Dunn, Donald H Jenkinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 239 KB

english, 1997

3

Highly preferential cleavage of unpaired guanines in DNA by a functionalized salen-nickel complex

Sylvain Routier, Jean-Luc Bernier, Jean-Pierre Catteau, Christian Bailly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

4

Bleomyclin model complex bearing a carbamoyl derived substituent capable of coordination to the chelated metal ion as a sixth ligand

Takayuki Arai, Kazuo Shinozuka, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 244 KB

english, 1997

5

Synthesis and hepatoprotective effects of soyasapogenol B derivatives

Kazue Sasaki, Nobuto Minowa, Hiroyuki Kuzuhara, Shoji Nishiyama, Shoji Omoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 190 KB

english, 1997

6

Phosphorothioate oligonucleotides: Largely reduced (N-1)-mer and phosphodiester content through the use of dimeric phosphoramidite synthons

Achim H. Krotz, Patrick Klopchin, Douglas L. Cole, Vasulinga T. Ravikumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 352 KB

english, 1997

7

α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE)

Todd L. Graybill, Catherine P. Prouty, Gary J. Speier, Denton Hoyer, Roland E. Dolle, Carla T. Helaszek, Mark A. Ator, Joanne Uhl, Joost Strastes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 386 KB

english, 1997

8

Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide

David P Czajkowski, Andhe V.N Reddy, Eduardo L Setti, Oludotun A Phillips, Ronald G Micetich, Chieko Kunugita, Samarendra N Maiti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 199 KB

english, 1997

9

Structure-activity studies of CTL inhibitory peptides derived from HLA Class I molecules

Erich J Schwartz, Jodi Goldberg, Carol Clayberger, Alan M Krensky, John H Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 281 KB

english, 1997

10

Synthesis and evaluation of the anticonvulsant activity of a series of 2-amino-1-phenyl-1-propanols derived from the metabolites of the antidepressant bupropion

David L. Musso, Nariman B. Mehta, Francis E. Soroko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 229 KB

english, 1997

11

SAR for MHC class II binding tetrapeptides: Correlation with potential binding site

Barry R Cunningham, Meheryar Rivetna, Richard L Tolman, Stacey J Flattery, Elizabeth A Nichols, Cheryl D Schwartz, Linda S Wicker, Jeffrey D Hermes, A.Brian Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 362 KB

english, 1997

12

Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

Michel Thérien, Christine Brideau, Chi Chung Chan, Wanda A. Cromlish, Jacques Yves Gauthier, Robert Gordon, Gillian Greig, Stacia Kargman, Cheuk Kun Lau, Yves Leblanc, Chun-Sing Li, Gary P. O'Neill, D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 270 KB

english, 1997

13

Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

Laird A Trimble, Nathalie Chauret, JoséM Silva, Deborah A Nicoll-Griffith, Chun-Sing Li, James A Yergey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

14

A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

P. Roy, Y. Leblanc, R.G. Ball, C. Brideau, C.C. Chan, N. Chauret, W. Cromlish, D. Ethier, J.Y. Gauthier, R. Gordon, G. Greig, J. Guay, S. Kargman, C.K. Lau, G. O'Neill, J. Silva, M. Thérien, C. van St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 253 KB

english, 1997

15

Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor

Terry A. Lyle, Zhongguo Chen, Sandra D. Appleby, Roger M. Freidinger, Stephen J. Gardell, S.Dale Lewis, Ying Li, Elizabeth A. Lyle, Joseph J. Lynch Jr., Anne M. Mulichak, Assunta S. Ng, Adel M. Naylor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 336 KB

english, 1997

16

S1 heterocyclic thrombin inhibitors

C Dominguez, D.J Carini, P.C Weber, R.M Knabb, R.S Alexander, C.A Kettner, R.R Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 191 KB

english, 1997

17

Editorial Board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 113 KB

english, 1997

18

Tetrahedron prize for creativity in organic chemistry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 54 KB

english, 1997

19

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 65 KB

english, 1997

20

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 290 KB

english, 1997

21

Combinatorial epitope search: Pitfalls of library design

Zhiguang Yu, Yen-Ho Chu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

22

2,3-Substituted 2-azanorbornanes as polar β-turn mimetics

David C. Horwell, Dorica Naylor, Henriëtte M.G. Willems

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 296 KB

english, 1997

23

Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)

Dennis J Hlasta, Donald C Bode, John J Court, Ranjit C Desai, Edward D Pagani, Paul J Silver

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 379 KB

english, 1997