Volume 7; Issue 13

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Bioorganic & Medicinal Chemistry Letters
Volume 7; Issue 13

Bioorganic & Medicinal Chemistry Letters

Volume 7; Issue 13

1

Biaryl substituted alkylboronate esters as thrombin inhibitors

M.L. Quan, J. Wityak, C. Dominguez, J.V. Duncia, C.A. Kettner, C.D. Ellis, A.Y. Liauw, J.M. Park, J.B. Santella, R.M. Knabb, M.J. Thoolen, P.C. Weber, R.R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 266 KB

english, 1997

2

Novel dithiocarbamate carbapenems1 with anti-MRSA activity

Norikazu Ohtake, Hideaki Imamura, Hideo Kiyonaga, Hideki Jona, Masayuki Ogawa, Shigemitsu Okada, Aya Shimizu, Minoru Moriya, Hiroki Sato, Yushin Tominaga, Koji Yamada, Masato Nakano, Ryosuke Ushijima,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 281 KB

english, 1997

3

Polyclonal catalytic antibody for hetero-cycloaddition of hepta-1,3-diene with ethyl glyoxylate an approach to the synthesis of 2-nonulosonic acid analogs

Yun-Jin Hu, Yong-Yong Ji, Yu-Lin Wu, Bing-Hui Yang, Ming Yeh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 237 KB

english, 1997

4

Syntheses and anticancer activity of ribonucleoside analogues containing thio-substituted five-membered heterocyclic base

Yun Ding, Yun-Yan Zhang, Jiong Zhang, Yao-Quan Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 247 KB

english, 1997

5

Antiinflammatory effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L.

Hisashi Matsuda, Yuhao Li, Toshiyuki Murakami, Kiyofumi Ninomiya, Nobuharu Araki, Masayuki Yoshikawa, Johji Yamahara

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 300 KB

english, 1997

6

Chemoenzymatic synthesis and characterization of a new type of carbohydrate-based cationic antimicrobial agents

Ole Kirk, Flemming D. Pedersen, Claus C. Fuglsang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 212 KB

english, 1997

7

Cytotoxic activity of neo-clerodane diterpenoids

Marina Gordaliza, JoséM. Miguel del Corral, María Luz de la Puente, María Dolores Garcia-Grávalos, Arturo San Feliciano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 340 KB

english, 1997

8

Novel non-nucleosidic phosphoramidites for oligonucleotide modification and labeling

Sheng-Hui Su, Rajkumar S Iyer, Sunil K Aggarwal, Krishan L Kalra

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 290 KB

english, 1997

9

New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

Tadashi Honda, Heather J. Finlay, Gordon W. Gribble, Nanjoo Suh, Michael B. Sporn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 286 KB

english, 1997

10

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang-I Lin, Panayota Bitha, Subas M. Sakya, Zhong Li, Stanley A. Lang Jr., Youjun Yang, Niraja Bhachech, William J. Weiss, Peter J. Petersen, Nilda V. Jacobus, Karen Bush, Raymond T. Testa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 241 KB

english, 1997

11

Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

Yang-I Lin, Panayota Bitha, Subas M. Sakya, Timothy W. Strohmeyer, Zhong Li, Ving J. Lee, Stanley A. Lang Jr., Youjun Yang, Niraja Bhachech, William J. Weiss, Peter J. Petersen, Nilda V. Jacobus, Kare

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 279 KB

english, 1997

12

A concise synthetic entry to substituted 2-aminothieno[2,3-d]pyrimidines via a gewald precursor

Minsheng Zhang, Richard W. Harper

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 270 KB

english, 1997

13

Analogues of trichosтatin a and trapoxin B as histone deacetylase inhibitors

Manfred Jung, Katharina Hoffmann, Gerald Brosch, Peter Loidl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 184 KB

english, 1997

14

Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen

Robert M. Adlington, Jack E. Baldwin, Beining Chen, Stephen L. Cooper, William McCoull, Gareth J. Pritchard, Trevor J. Howe, Gerald W. Becker, Robert B. Hermann, Ann M. McNulty, Blake L. Neubauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 316 KB

english, 1997

15

Additions and corrections

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 32 KB

english, 1997

16

Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors

Tomoji Aotsuka, Naoki Abe, Kanako Fukushima, Naoki Ashizawa, Motoyuki Yoshida

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 282 KB

english, 1997

17

Synthesis and antitumor activity of novel cyclopropapyrroloindole(CPI) derivatives bearing methoxycarbonyl and trifluoromethyl groups

Yasumichi Fukuda, Hirosuke Furuta, Futoshi Shiga, Yasuo Oomori, Yoshie Kusama, Hiroyuki Ebisu, Shiro Terashima

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 321 KB

english, 1997

18

Conformational analysis of an anxiolytic agent: tandospirone in aqueous solution

Jun-etsu Igarashi, Tamiki Nishimura, Makoto Sunagawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 274 KB

english, 1997

19

Probing the formation of a parallel heterodimeric coiled coil by fluorescence quenching

Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 247 KB

english, 1997

20

4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists

Maria J. Mokrosz, Beata Duszyńska, Aleksandra Klodzińska, Anna Dereń-Wesolek, Ewa Chojnacka-Wójcik, Timothy C. Baranowski, Ibrahim M. Abdou, Naomi P. Redmore, Lucjan Strekowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

21

Synthesis and characterization of polyaspartic acid-carbohydrate conjugates: Multivalent sialyl lewis

Gebhard Thoma, Beat Ernst, Franz Schwarzenbach, Rudolf O. Duthaler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 222 KB

english, 1997

22

A very short, efficient and inexpensive synthesis of the prodrug form of SC-54701A a platelet aggregation inhibitor

J. Cossy, A. Schmitt, C. Cinquin, D. Buisson, D. Belotti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 122 KB

english, 1997

23

Novel inhibitors of the prenylated protein methyltransferase reveal distinctive structural requirements

Daniele Marciano, Ziporet Aharonson, Tal Varsano, Roni Haklai, Yoel Kloog

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 286 KB

english, 1997

24

Prolyl endopeptidase inhibitors1: N-acyl derivatives of L-thioproline-pyrrolidine

Kánai Károly, Erdo&amp, ̋ Sándor, Susán Edit, Fehér Miklós, Sipos Judit, Podányi Benjámin, Szappanos Andrea, Hermecz István

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 238 KB

english, 1997

25

RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor

Toshiyuki Suzawa, Kenji Shibata, Takeo Tanaka, Yuzuru Matsuda, Motoo Yamasaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 327 KB

english, 1997

26

Synthesis and structure-activity relationships of novel antiseptics

Hidetsugu Tsubouchi, Kinue Ohguro, Koichi Yasumura, Hiroshi Ishikawa, Mikio Kikuchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 206 KB

english, 1997

27

An efficient synthesis of short-chain sphingomyelin analogs and their susceptibility to hydrolysis catalyzed by sphingomyelinase

Masahiro Murakami, Seiji Iwama, Shinobu Fujii, Kiyoshi Ikeda, Shigeo Katsumura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

28

Recognition and cleavage of DNA by a distamycin-salen·copper conjugate

Sylvain Routier, Jean-Luc Bernier, Jean-Pierre Catteau, Christian Bailly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 283 KB

english, 1997

29

Potent selective thienoxazinone inhibitors of herpes proteases

Richard L. Jarvest, Susan C. Connor, Joselina G. Gorniak, L.John Jennings, Halina T. Serafinowska, Andrew West

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 325 KB

english, 1997

30

Alkylphospho-L-serine analogues: Synthesis of cytostatically active alkylphosphono derivatives

H. Brachwitz, M. Ölke, J. Bergmann, P. Langen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 226 KB

english, 1997

31

Alanyl-PNA oligomers: A new system for intercalation

Ulf Diederichsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 246 KB

english, 1997

32

Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Shanghao Liu, Andrew D. Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 350 KB

english, 1997

33

FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of parkinson's disease

G.S. Hamilton, W. Huang, M.A. Connolly, D.T. Ross, H. Guo, H.L. Valentine, P.D. Suzdak, J.P. Steiner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 372 KB

english, 1997

34

8-(6-Aminohexyl) amino-cyclic ATPR: A new affinity probe for the study of cyclic ADPR-binding proteins

Fang-Jie Zhang, Charles J. Sih

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

35

Synthesis and in vitro antibacterial activities of novel conformationally restricted hygromycin a analogues

Christopher B. Cooper, Kyle T. Blair, Christopher S. Jones, Martha L. Minich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 293 KB

english, 1997

36

Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

Robert J. Cherney, Carl P. Decicco, David J. Nelson, Li Wang, Dayton T. Meyer, Karl D. Hardman, Robert A. Copeland, Elizabeth C. Arner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 301 KB

english, 1997

37

Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase

Barry G. Shearer, Shuliang Lee, Karl W. Franzmann, Helen A.R. White, Daniella C.J. Sanders, Rachel J. Kiff, Edward P. Garvey, Eric S. Furfine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 301 KB

english, 1997

38

Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells

Heather J. Finlay, Tadashi Honda, Gordon W. Gribble, David Danielpour, Nicole E. Benoit, Nanjoo Suh, Charlotte Williams, Michael B. Sporn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 181 KB

english, 1997

39

Constrained β-alanine based GpIIb/IIIa antagonists

Scott I Klein, Mark Czekaj, Bruce F Molino, Valeria Chu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 291 KB

english, 1997

40

Molecular modeling of the interaction of trypanocide guanyl hydrazones with B-DNA

Osvaldo A. Santos-Filho, J.Daniel Figueroa-Villar, Martha T. Araujo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 250 KB

english, 1997

41

Synthesis and properties of hammerhead ribozymes stabilized against nucleases by different 2′-modifications: methoxyethoxy-, fluoro- and amino groups

Michaela Scherr, Christian Klebba, Robert Häner, Arnold Ganser, Joachim W. Engels

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 298 KB

english, 1997

42

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 107 KB

english, 1997

43

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 616 KB

english, 1997

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