Volume 8; Issue 16

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Bioorganic & Medicinal Chemistry Letters
Volume 8; Issue 16

Bioorganic & Medicinal Chemistry Letters

Volume 8; Issue 16

1

Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

Kevin N. Dack, Roger P. Dickinson, Clive J. Long, John Steele

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 287 KB

english, 1998

2

The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice

Kunio Suzuki, Takeshi Shimizu, Tadashi Nakata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 330 KB

english, 1998

3

Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3

Toshie Fujishima, Zhaopeng Liu, Daishiro Miura, Manabu Chokki, Seiichi Ishizuka, Katsuhiro Konno, Hiroaki Takayama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 231 KB

english, 1998

4

Solid phase synthesis of oligomannopeptoids that mimic the concanavalin A-binding trimannoside

Hideya Yuasa, Yujiro Kamata, Sadamu Kurono, Hironobu Hashimoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 284 KB

english, 1998

5

Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach

Rainer Albert, Hellmut Knecht, Elsebeth Andersen, Valerie Hungerford, Max H. Schreier, Christos Papageorgiou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 275 KB

english, 1998

6

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

Ravindra Kumar, Sanjay K. Singh, Alexei A. Koshkin, Vivek K. Rajwanshi, Michael Meldgaard, Jesper Wengel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 269 KB

english, 1998

7

Anti-aids agents 33.1 Synthesis and anti-HIV activity of mono-methyl substituted 3′,4′-di-O-(−)-camphanoyl-(+)-cis-khellactone (DCK) analogues

Lan Xie, Yasuo Takeuchi, L. Mark Cosentino, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

8

Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation

Ekambar R. Kandimalla, Denise R. Shaw, Sudhir Agrawal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 376 KB

english, 1998

9

A dipyrido [2,3-b:3′,2′-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine

Alexey B. Dyatkin, Janice R. Brickwood, John R. Proudfoot

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 202 KB

english, 1998

10

Design and synthesis of conformationally-constrained MMP inhibitors

Michael G. Natchus, Menyan Cheng, Christopher T. Wahl, Stanislaw Pikul, Neil G. Almstead, Rimma S. Bradley, Yetunde O. Taiwo, Glen E. Mieling, C.Michelle Dunaway, Catherine E. Snider, John M. McIver,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 272 KB

english, 1998

11

Kampanols: novel ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis

Sheo B. Singh, Deborah L. Zink, Marie Williams, Jon D. Polishook, Manuel Sanchez, Keith C. Silverman, Russell B. Lingham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 370 KB

english, 1998

12

Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists

David J. Wustrow, Thomas Capiris, Ronald Rubin, James A. Knobelsdorf, Hyacinth Akunne, M.Duff Davis, Robert MacKenzie, Thomas A. Pugsley, Kim T. Zoski, Thomas G. Heffner, Lawrence D. Wise

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 205 KB

english, 1998

13

Antineoplastic agents 397: Isolation and structure of sesterstatins 4 and 5 from hyrtios erecta (the republic of maldives)

George R. Pettit, Rui Tan, Noeleen Melody, Zbigniew A. Cichacz, Delbert L. Herald, Michael S. Hoard, Robin K. Pettit, Jean-Charles Chapuis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 327 KB

english, 1998

14

Synthesis and pharmacological evaluation of benzofuran-acetamides as “antineophobic” mitochondrial DBI receptor complex ligands

Yi Liao, Alan P. Kozikowski, Alessandro Guidotti, Erminio Costa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 264 KB

english, 1998

15

Synthesis of novel substituted pyridines as inhibitors of endothelin coverting enzyme-1 (ECE-1)

Mark A. Massa, William C. Patt, Kyunghye Ahn, Andre M. Sisneros, Sarah B. Herman, Annette Doherty

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 292 KB

english, 1998

16

Potent inhibition of protein-tyrosine phosphatese-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT)

Peter P Roller, Li Wu, Zhong-Yin Zhang, Terrence R Burke Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

17

Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity

Stephen Hanessian, Ulrich Reinhold, Michel Saulnier, Stephen Claridge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 301 KB

english, 1998

18

The structure-activity relationships of a series of suicide inhibitors of phospholipase A2

Lin Yu, Robert J. Ternansky, Edward J. Victoria, Julia Chang, Stephen M. Coutts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 251 KB

english, 1998

19

Novel H3 receptor antagonists. Sulfonamide homologs of histamine

Ronald Wolin, Michael Connolly, Adriano Afonso, John A. Hey, Hoyan She, Maria A. Rivelli, Shirley M. Willams, Robert E. West Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 325 KB

english, 1998

20

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI

Ze-Qi Xu, Robert W. Buckheit Jr., Tracy L. Stup, Michael T. Flavin, Albert Khilevich, John D. Rizzo, Lin Lin, David E. Zembower

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 337 KB

english, 1998

21

3-Pyridyloxypropanolamine agonists of the β3 adrenergic receptor with improved pharmacokinetic properties

Ann E Weber, Hyun O Ok, Raul F Alvaro, Mari R Candelore, Margaret A Cascieri, Shuet-Hing L Chiu, Liping Deng, Michael J Forrest, Gary J Hom, Jennifer E Hutchins, John Kao, D.Euan MacIntyre, Robert J M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 376 KB

english, 1998

22

Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers

C.M. Dreef-Tromp, J.E.M. Basten, M.A. Broekhoven, T.G. van Dinther, M. Petitou, C.A.A. van Boeckel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 352 KB

english, 1998

23

Synthesis of a paclitaxel isomer: C-2-acetoxy-C-4-benzoate paclitaxel

Shu-Hui Chen, Vittorio Farina, Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

24

Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

Chen Mao, Rakesh Vig, T.K. Venkatachalam, Elise A. Sudbeck, Fatih M. Uckun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 335 KB

english, 1998

25

Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-Δ8-THC

John Liddle, John W. Huffman, Jenny L. Wiley, Billy R. Martin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 207 KB

english, 1998

26

Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

Brad O. Buckman, Raju Mohan, Sunil Koovakkat, Amy Liang, Lan Trinh, Michael M. Morrissey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 352 KB

english, 1998

27

Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity

Junichi Sakaki, Toshiki Murata, Yoko Yuumoto, Ikushi Nakamura, Thomas Frueh, Thomas Pitterna, Genji Iwasaki, Kyoko Oda, Takaki Yamamura, Kenji Hayakawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 247 KB

english, 1998

28

Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630

Junichi Sakaki, Toshiki Murata, Yoko Yuumoto, Ikushi Nakamura, Kenji Hayakawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 284 KB

english, 1998

29

Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion

Yoshiteru Ida, Yasuaki Hirai, Tetsuya Kajimoto, Kazushi Shingu, Tsuyoshi Miura, Naoko Kuwahara, Susumu Taguchi, Katsumi Sasaki, Yukio Kuroiwa, Toshinori Yamamoto, Ichiro Arai, Sakae Amagaya, Yasuhiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

30

Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents

Nobuhiro Sakurai, Mitsuharu Sano, Fumihiro Hirayama, Tsuyoshi Kuroda, Satoru Uemori, Akihiko Moriguchi, Katsuhiro Yamamoto, Yoshifumi Ikeda, Takeshi Kawakita

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 271 KB

english, 1998

31

Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga

Hisashi Matsuda, Toshiyuki Murakami, Tadashi Kageura, Kiyofumi Ninomiya, Iwao Toguchida, Norihisa Nishida, Masayuki Yoshikawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 338 KB

english, 1998

32

Reactions of 7- and 9-aminoadenines with 2,4-pentanedione. Formation of new ring systems, pyridazino[6,1-f]purine and pyridazino[1,6-e]purine

Toyo Kaiya, Tetsuya Saga, Yuriko Yamagata, Kohfuku Kohda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 302 KB

english, 1998

33

Novel imidazole derivatives with subtype-selective antimuscarinic activity

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 214 KB

english, 1998

34

Conformationally restricted analogues of nicotine and anabasine

Jean-Michel Vernier, Heather Holsenback, Nicholas D.P. Cosford, Jeffrey P. Whitten, Frédérique Menzaghi, Richard Reid, Tadimeti S. Rao, Aida I. Sacaan, G.Kenneth Lloyd, Carla M. Suto, Laura E. Chavez-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 321 KB

english, 1998

35

L-tryptophan urea amides as NK1NK2 dual antagonists

Hongbo Qi, Shrenik K. Shah, Margaret A. Cascieri, Sharon J. Sadowski, Malcolm MaCcoss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 226 KB

english, 1998

36

The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors

Douglas H. Steinman, Michael L. Curtin, Robert B. Garland, Steven K. Davidsen, H.Robin Heyman, James H. Holms, Daniel H. Albert, Terry J. Magoc, Ildiko B. Nagy, Patrick A. Marcotte, Junling Li, Dougla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 345 KB

english, 1998

37

C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential

Mark T. Goulet, Shelli R. McAlpine, Mary Jo Staruch, Samuel Koprak, Francis J. Dumont, John G. Cryan, Gregory J. Wiederrecht, Raymond Rosa, Mary Beth Wilusz, Laurence B. Peterson, Matthew J. Wyvratt,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 381 KB

english, 1998

38

Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product

Yousef Al-Abed, Erwin Schleicher, Wolfgang Voelter, Hartmut Liebich, Andrew Papoulis, Richard Bucala

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

39

4- [(1H - imidazol - 4 - YL) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor

Robert Aslanian, Joan E. Brown, N.-Y. Shih, Mwangi wa Mutahi, Michael J. Green, Susan She, Maurice Del Prado, Robert West, John Hey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 287 KB

english, 1998

40

A simple procedure for solid-phase synthesis of peptide nucleic acids with N-terminal cysteine

Thomas E. Goodwin, Ricky D. Holland, Jackson O. Lay Jr., Kevin D. Raney

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 301 KB

english, 1998

41

Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast

Bruno Tse, James M. Balkovec, Charles M. Blazey, Ming-Jo Hsu, Jennifer Nielsen, Dennis Schmatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 213 KB

english, 1998

42

Tetrahedron prize for creativity in organic chemistry 1998

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

File:

PDF, 24 KB

1998

43

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 128 KB

english, 1998

44

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 658 KB

english, 1998

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