Volume 9; Issue 18

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Bioorganic & Medicinal Chemistry Letters
Volume 9; Issue 18

Bioorganic & Medicinal Chemistry Letters

Volume 9; Issue 18

1

Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants

Tero Kunnari, Kristiina Ylihonko, Anne Hautala, Karel D. Klika, Pekka Mäntsälä, Juha Hakala

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 195 KB

english, 1999

2

Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II

Seiichi Sato, Yasuyo Suga, Toshihiko Yoshimura, Ryusuke Nakagawa, Takashi Tsuji, Ken Umemura, Toshiwo Andoh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 208 KB

english, 1999

3

Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains

Yi-Meen Chou, Ming Chih Lai, Tsai-Mian Hwang, Chi Wi Ong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 197 KB

english, 1999

4

Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: Structure requirement and suppression of gastric emptying

Hisashi Matsuda, Hiroshi Shimoda, Toshiaki Uemura, Masayuki Yoshikawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 315 KB

english, 1999

5

Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif

Isabelle Prévot-Halter, Christian J. Leumann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 235 KB

english, 1999

6

Oligonucleotides containing 4′-C-aminomethyl-2′-modified thymidines show increased binding affinity towards DNA and RNA

Henrik M. Pfundheller, Jesper Wengel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 379 KB

english, 1999

7

Leishmanicidal activity of combretastatin analogues and heteroanalogues

Benedicto del Rey, Angel C. Ramos, Esther Caballero, Alba Inchaustti, Gloria Yaluff, Manuel Medarde, Antonieta Rojas de Arlas, Arturo San Feliciano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 218 KB

english, 1999

8

Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor

Kim Y Avenell, Izzy Boyfield, Michael S Hadley, Christopher N Johnson, David J Nash, Graham J Riley, Geoffrey Stemp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 333 KB

english, 1999

9

[35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: A versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling

Kyoji Furuta, Takamitsu Hosoya, Keiichiro Tomokiyo, Sachio Okuda, Akihiko Kuniyasu, Hitoshi Nakayama, Toshihisa Ishikawa, Masaaki Suzuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 349 KB

english, 1999

10

Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonypiperidin-1-yl)alkanes as potent antiarrhythmic agents

C.Tripathi Ravish, Suresh K. Pandey, K. Kar, M. Dikshit, Anil K. Saxena

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 321 KB

english, 1999

11

Asymmetric synthesis and antitumor activity of cycloalkanin

Xihan Wu, Liang Xu, Junchao Cai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 189 KB

english, 1999

12

Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors

Jeffrey H. Toney, Kelly A. Cleary, Gail G. Hammond, Xiling Yuan, Walter J. May, Steven M. Hutchins, Wallace T. Ashton, Dana E. Vanderwall

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 290 KB

english, 1999

13

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

Michael R. Wiley, Leonard C. Weir, Steven L. Briggs, Nickolay Y. Chirgadze, David Clawson, Donetta S. Gifford-Moore, Aaron L. Schacht, Gerald F. Smith, Vasu Vasudevan, Larry L. Zornes, Valentine J. Kl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 336 KB

english, 1999

14

N-[2-(1-cyclohexenyl)ethyl]-N′-[2-(5-bromopyridyl)]-thiourea and N′-[2-(1-cyclohexenyl)ethyl]-N′-[2-(5-chloropyridyl)]- thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1

Fatih M. Uckun, Chen Mao, Sharon Pendergrass, Danielle Maher, Dan Zhu, Lisa Tuel-Ahlgren, T.K. Venkatachalam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 353 KB

english, 1999

15

Discovery of CP-199,330 and CP-199,331: Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity

R.J. Chambers, A. Marfat, G.W. Antognoli, J.B. Cheng, D.B. Damon, A.V. Kuperman, T.C. Liston, C. Mebus, J.S. Pillar, J.T. Shirley, J.W. Watson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

16

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework

Nan-Horng Lin, Melwyn A. Abreo, David E. Gunn, Suzanne A. Lebold, Edmund L. Lee, James T. Wasicak, Ann-Marie Hettinger, Jerome F. Daanen, David S. Garvey, Jeffrey E. Campbell, James P. Sullivan, Micha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 329 KB

english, 1999

17

Construction of sequence-selective peptide receptors from conformationally restricted eta- and theta- amino acids

Kevin Ryan, W.Clark Still

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 331 KB

english, 1999

18

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

Andrzej W. Lipkowski, Aleksandra Misicka, Peg Davis, Dagmar Stropova, Jacqueline Janders, Magdalena Lachwa, Frank Porreca, Henry I. Yamamura, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 203 KB

english, 1999

19

New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor

Réjean Ruel, Patrick Lacombe, Mark Abramovitz, Claude Godbout, Sonia Lamontagne, Chantal Rochette, Nicole Sawyer, Rino Stocco, Nathalie M. Tremblay, Kathleen M. Metters, Marc Labelle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 277 KB

english, 1999

20

Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors

Michael R. Becker, William R. Ewing, Roderick S. Davis, Henry W. Pauls, Cuong Ly, Aiwen Li, Helen J. Mason, Yong Mi Choi-Sledeski, Alfred P. Spada, Valeria Chu, Karen D. Brown, Dennis J. Colussi, Robe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 342 KB

english, 1999

21

A new method for introducing amidate linkages in oligonucleotides using phosphoramidite chemistry

Peter W. Davis, Steven A. Osgood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 130 KB

english, 1999

22

Combinatorial search of substituted β-cyclodextrins for phosphatase-like activity

Jiaxin Yu, Yongzhong Zhao, Mark J Holterman, Duane L Venton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 285 KB

english, 1999

23

A comparison of the α-helix forming propensities and hydrogen bonding properties of serine phosphate and α-amino-γ-phosphonobutyric acid

Sebastian Liehr, H.Keith Chenault

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 238 KB

english, 1999

24

9-[(2′S,3′S)-3′-formyl-2′,3′-dihydroxypropyl]adenine: A facile affinity-labeling probe of human S-adenosyl-l-homocysteine hydrolase

Yukio Kitade, Masayuki Nakanishi, Chizuko Yatome

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 185 KB

english, 1999

25

Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects

Hea-Young Park Choo, Bum-Jun Chung, Sung-Hyun Chung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 164 KB

english, 1999

26

Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

Jin-Sheng Zhang, Jian Ding, Qin-Mei Tang, Mai Li, Ming Zhao, Li-Juan Lu, Ling-Ji Chen, Sheng-Tao Yuan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 267 KB

english, 1999

27

Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles

Ae Nim Pae, Hye Yeon Kim, Hyun Jin Joo, Bo Hyung Kim, Yong Seo Cho, Kyung Il Choi, Jung Hoon Choi, Hun Yeong Koh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 294 KB

english, 1999

28

3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis

Ae Nim Pae, Su Yeon Kim, Hye Yeon Kim, Hyun Jin Joo, Yong Seo Cho, Kyung Il Choi, Jung Hoon Choi, Hun Yeong Koh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

29

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

30

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 417 KB

english, 1999

31

Keyword list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

File:

PDF, 37 KB

1999

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