Volume 9; Issue 7

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Bioorganic & Medicinal Chemistry Letters
Volume 9; Issue 7

Bioorganic & Medicinal Chemistry Letters

Volume 9; Issue 7

1

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Donald J.P. Pinto, Douglas G. Batt, William J. Pitts, Joseph J. Petraitis, Michael J. Orwat, Shuaige Wang, James W. Jetter, Susan R. Sherk, Gregory C. Houghton, Robert A. Copeland, Maryanne B. Covingt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 305 KB

english, 1999

2

6-(1-hydroxyalkyl)penam sulfone derivatives as inhibitors of class a and class C β-lactamases I

Panayota Bitha, Zhong Li, Gerardo D. Francisco, Beth A. Rasmussen, Yang-I Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 294 KB

english, 1999

3

6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C β-lactamases II

Panayota Bitha, Zhong Li, Gerardo D. Francisco, Youjun Yang, Peter J. Petersen, Eileen Lenoy, Yang-I Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 297 KB

english, 1999

4

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

5

Adenosine receptor ligands with oxygenated N6-substituents

Sally A. Hutchinson, Stephen P. Baker, Peter J. Scammells

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

6

Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure

Ken S. Feldman, Kiran Sahasrabudhe, Randall S. Smith, William J. Scheuchenzuber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 337 KB

english, 1999

7

Investigation of new potent KDO-8-phosphate synthetase inhibitors

Ph. Coutrot, S. Dumarçay, Ch. Finance, M. Tabyaoui, B. Tabyaoui, C. Grison

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 240 KB

english, 1999

8

Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents

Marinella Antolini, Andrea Bozzoli, Chiara Ghiron, Gordon Kennedy, Tino Rossi, Antonella Ursini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 235 KB

english, 1999

9

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Celia Dominguez, Daniel E. Duffy, Qi Han, Richard S. Alexander, Robert A. Galemmo Jr., Jeongsook M. Park, Pancras C. Wong, Eugene C. Amparo, Robert M. Knabb, Joseph Luettgen, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 338 KB

english, 1999

10

Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: Identification of αvβ3 antagonists lead compounds

Arlene L. Rockwell, Maria Rafalski, William J. Pitts, Douglas G. Batt, Joseph J. Petraitis, William F. DeGrado, Shaker Mousa, Prabhakar K. Jadhav

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 313 KB

english, 1999

11

Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: Unique structural analogs of tacrine based on the BCD-ring of arisugacin

Shane J. Degen, Kristen L. Mueller, Hong C. Shen, Jason A. Mulder, Geoffrey M. Golding, Lin-li Wei, Craig A. Zificsak, Amy Neeno-Eckwall, Richard P. Hsung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 368 KB

english, 1999

12

Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols

John N. Freskos, Brent V. Mischke, Gary A. DeCrescenzo, Robert Heintz, Daniel P. Getman, Susan C. Howard, Nandini N. Kishore, Joseph J. McDonald, Grace E. Munie, Shaukat Rangwala, Craig A. Swearingen,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 251 KB

english, 1999

13

N-Hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

Peter J. Connolly, Steven K. Wetter, Kimberly N. Beers, Stephanie C. Hamel, Robert H.K. Chen, Michael P. Wachter, Justin Ansell, Monica M. Singer, Michele Steber, David M. Ritchie, Dennis C. Argentier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 382 KB

english, 1999

14

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

James P. Edwards, Robert I. Higuchi, David T. Winn, Charlotte L.F. Pooley, Thomas R. Caferro, Lawrence G. Hamann, Lin Zhi, Keith B. Marschke, Mark E. Goldman, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 351 KB

english, 1999

15

Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone

Lin Zhi, Christopher M. Tegley, Keith B. Marschke, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 244 KB

english, 1999

16

Regeneration of 4-thio-2′-deoxyuridine residues in DNA

Robert S. Coleman, Richard M. Pires

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

17

Synthesis, aggregation, and neurotoxicity of the alzheimer's Aß1-42 amyloid peptide and its isoaspartyl isomers

Hiroyuki Fukuda, Takahiko Shimizu, Mitsunari Nakajima, Hiroshi Mori, Takuji Shirasawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 321 KB

english, 1999

18

4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice

Kohji Yamaguchi, Mika Yada, Tomoko Tsuji, Yuriko Hatanaka, Ken-ichi Goda, Takeo Kobori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 202 KB

english, 1999

19

Reactions of chloride salts of 7-amino-9-ethylguanine and 1-amino-3-methylbenzimidazoles with lead(IV) acetate: Formation of 8-aza-9-ethylguanine and 1-methyl-1H-benzotriazoles

Toyo Kaiya, Shinsuke Aoyama, Kohfuku Kohda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 284 KB

english, 1999

20

Affinity of 5-thio-l-fucose-containing lewis X (LeX) trisaccharide analogs to anti-LeX monoclonal antibody

Osamu Tsuruta, Hideya Yuasa, Hironobu Hashimoto, Sadamu Kurono, Shin Yazawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 222 KB

english, 1999

21

Thrombin inhibitors based on a propargylglycine template

Koo Lee, Sang Yeul Hwang, Cheol Won Park

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 303 KB

english, 1999

22

Total synthesis of an antioxidant isolated from yeast via palladium-catalyzed coupling and its application for related compounds

Shuji Jinno, Takaaki Okita, Kuniyo Inouye

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 194 KB

english, 1999

23

New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity

Aldo Balsamo, Silvia Barontini, Federico Calvani, Daniela Gentili, Marco Macchia, Armando Rossello, Enza Di Modugno, Antonio Felici

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 313 KB

english, 1999

24

Solid phase synthesis of structurally diverse pyrimido[4,5-d] pyrimidines for the potential use in combinatorial chemistry

Sanjay K. Srivastava, W. Haq, P.M.S. Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 132 KB

english, 1999

25

Three-dimensional structure-function relationship of vitamin D: Side chain location and various activities

Keiko Yamamoto, Hiroshi Ooizumi, Kazuhiko Umesono, Annemieke Verstuyf, Roger Bouillon, Hector F. DeLuca, Toshimasa Shinki, Tatsuo Suda, Sachiko Yamada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 319 KB

english, 1999

26

Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors

Benoit Bachand, John DiMaio, M.Arshad Siddiqui

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 324 KB

english, 1999

27

N-(4-Bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer

Lucjan Strekowski, Maged Henary, Nanhye Kim, Bozena B. Michniak

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

28

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

Anthony J. Cocuzza, Frank W. Hobbs, Charles R. Arnold, Dennis R. Chidester, Jerry A. Yarem, Steven Culp, Lawrence Fitzgerald, Paul J. Gilligan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

29

Use of the suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

Anthony J. Cocuzza, Dennis R. Chidester, Steven Culp, Lawrence Fitzgerald, Paul Gilligan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 233 KB

english, 1999

30

Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′-O-methylated 2-5A-antisense oligonucleotides

Hagen Cramer, Mark R. Player, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 378 KB

english, 1999

31

A straightforward synthetic approach for roxindole

Jos H.M Lange, Johannes C de Jong, Hans J Sanders, Geb M Visser, Chris G Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 105 KB

english, 1999

32

Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane

R. Iori, R. Bernardi, D. Gueyrard, P. Rollin, S. Palmieri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

33

Corrigendum

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 30 KB

english, 1999

34

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 99 KB

english, 1999

35

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 501 KB

english, 1999

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