Volume 9; Issue 8

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Bioorganic & Medicinal Chemistry Letters
Volume 9; Issue 8

Bioorganic & Medicinal Chemistry Letters

Volume 9; Issue 8

1

The discovery of orally available thrombin inhibitors: Optimisation of the P1 pharmacophore

John Ambler, David Bentley, Lyndon Brown, Karen Dunnet, Dave Farr, Diana Janus, Darren Le Grand, Keith Menear, Mark Mercer, Mark Talbot, Morris Tweed, Bernard Wathey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 258 KB

english, 1999

2

Synthesis, structural characterization and antitumor activity evaluations of copper complex with tetraazamacrocyclic ligand

Deyuan Kong, Chen Qin, Linhua Meng, Yuyuan Xie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 254 KB

english, 1999

3

Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II

Yoshiro Tatsu, Yasushi Shigeri, Atsuhiko Ishida, Kameshita Isamu, Hitoshi Fujisawa, Noboru Yumoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 201 KB

english, 1999

4

Microanalysis of a selective potent anti-Helicobacter pylori compound in a Brazilian Medicinal Plant, Myroxylon peruiferum and the activity of analogues

Ayumi Ohsaki, Junko Takashima, Noriko Chiba, Makoto Kawamura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 276 KB

english, 1999

5

Synthesis of 2′,3′-dideoxy-3′-C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent

Eiko Ichikawa, Shosuke Yamamura, Kuniki Kato

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

6

A new anti-tubulin agent containing the benzo[b]thiophene ring system

Kevin G. Pinney, A.Dawn Bounds, Koren M. Dingeman, Vani P. Mocharla, George R. Pettit, Ruoli Bai, Ernest Hamel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 396 KB

english, 1999

7

Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase

David J. Augeri, Dave Janowick, Douglas Kalvin, Gerry Sullivan, John Larsen, Daniel Dickman, Hong Ding, Jerry Cohen, Jang Lee, Robert Warner, Peter Kovar, Sajeev Cherian, Badr Saeed, Haichao Zhang, St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 269 KB

english, 1999

8

Synthesis and biological activity of trans-2,3-dihydroraloxifene

Christopher R. Schmid, Andrew L. Glasebrook, Jerry W. Misner, Gregory A. Stephenson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 243 KB

english, 1999

9

Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′-C-bridged 2′-deoxynucleosides

Guangyi Wang, Esmir Gunic, Jean-Luc Girardet, Vesna Stoisavljevic

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

10

1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIa phospholipase A2: X-ray structure of the complex and interfacial selection of inhibitors from a structural library

M.D. Bryant, K.E. Flick, R.S. Koduri, D.C. Wilton, B.L. Stoddard, M.H. Gelb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 463 KB

english, 1999

11

Arachidonic acid amide inhibitors of gap junction cell-cell communication

Dale L. Boger, Haruhiko Sato, Aaron E. Lerner, Xiaojun Guan, Norton B. Gilula

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 206 KB

english, 1999

12

Trichodiene synthase: Mechanism-based inhibition of a sesquiterpene cyclase

David E. Cane, Todd E. Bowser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 360 KB

english, 1999

13

Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line

Anouar Al-Omar, Souad Abdou, Laurence De Robertis, Alain Marsura, Chantal Finance

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 332 KB

english, 1999

14

Synthesis of a water-soluble analog of 6-methyl-3-N-alkyl catechol labeled with carbon 13: NMR approach to the reactivity of poison ivy/oak sensitizers toward proteins

Gilles Goetz, Emmanuel Meschkat, Jean-Pierre Lepoittevin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 357 KB

english, 1999

15

Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones

Chung-Kyu Ryu, In-Kyung Lee, Sung-Hee Jung, Chong-Ock Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 271 KB

english, 1999

16

Photocleavage coupling reactions between cyclohexa-2,4-dienone sulfone derivatives and amines by visible light irradiation

Young Mee Kim, Tae Woo Kwon, Sung Kee Chung, Derek H.R. Barton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 221 KB

english, 1999

17

Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

Shinwa Kurihara, Takeshi Tsumuraya, Ikuo Fujii

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 309 KB

english, 1999

18

New synthetic heparin mimetics able to inhibit thrombin and factor Xa

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Jean-P. Hérault, Jean-C. Lormeau, Jean-M. Herbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 376 KB

english, 1999

19

Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

Maurice Petitou, Pierre-Alexandre Driguez, Philippe Duchaussoy, Jean-Pascal Hérault, Jean-Claude Lormeau, Jean-Marc Herbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 371 KB

english, 1999

20

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, Steven Kramer, John J. Talley, Thomas Penning, Paul Collins, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Jaime Masferrer, Ben Zweifel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

21

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, D.J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang, John J. Talley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 212 KB

english, 1999

22

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

23

Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers

Lain-Yen Hu, Todd R. Ryder, Sham S. Nikam, Elizabeth Millerman, Balazs G. Szoke, Michael F. Rafferty

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

24

New photoaffinity analogs of paclitaxel

Iwao Ojima, Pierre-Yves Bounaud, David G. Ahern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 356 KB

english, 1999

25

Synthesis of (2S,3R)-β-methyltyrosine catalyzed by tyrosine phenol-lyase

Kyonghee Kim, Philip A. Cole

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 249 KB

english, 1999

26

Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

Ashit K Ganguly, Jinping L McCormick, Anil K Saksena, Pradip R Das, Tze-Ming Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 332 KB

english, 1999

27

Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa

John M. Fevig, Joseph Buriak Jr., Pieter F.W. Stouten, Robert M. Knabb, Gilbert N. Lam, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 361 KB

english, 1999

28

Preparation of amino acid conjugates of betulinic acid with activity against human melanoma

Hyeh-Jean Jeong, Hee-Byung Chai, So-Young Park, Darrick S.H.L Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 252 KB

english, 1999

29

Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C

Aleksey V. Rukavishnikov, Tatiana O. Zaikova, G.Bruce Birrell, John F.W. Keana, O. Hayes Griffith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 225 KB

english, 1999

30

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 78 KB

english, 1999

31

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 439 KB

english, 1999