Volume 93

Bioorganic Chemistry

Volume 93

1

Aminonaphthalimide hybrids of mitoxantrone and amonafide as anticancer and fluorescent cellular imaging agents

Johnson, Alex D., Zammit, Rodrianne, Vella, Jasmine, Valentino, Mario, Buhagiar, Joseph A., Magri, David C.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 7.18 MB

english, 2019

2

Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site

Yin, Yong, Lian, Bao-Ping, Xia, Yuan-Zheng, Shao, Yu-Ying, Kong, Ling-Yi

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 416 KB

english, 2019

3

Identification of a potent and selective gametocytocidal antimalarial agent from the stem barks of Lophira lanceolata

Lopatriello, Annalisa, Soré, Harouna, Habluetzel, Annette, Parapini, Silvia, D'Alessandro, Sarah, Taramelli, Donatella, Taglialatela-Scafati, Orazio

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 584 KB

english, 2019

4

Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors

Pogaku, Vinay, Gangarapu, Kiran, Basavoju, Srinivas, Tatapudi, Kiran Kumar, Katragadda, Suresh Babu

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.40 MB

english, 2019

5

STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis

Jang, Hyun-Jae, Lim, Hyung-Jin, Park, Eun-Jae, Lee, Seung-Jae, Lee, Soyoung, Lee, Seung Woong, Rho, Mun-Chual

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 2.04 MB

english, 2019

6

Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents

Ansari, Mahsa, Shokrzadeh, Mohammad, Karima, Saeed, Rajaei, Shima, Hashemi, Seyedeh Mahdieh, Mirzaei, Hassan, Fallah, Marjan, Emami, Saeed

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.96 MB

english, 2019

7

Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes

Chantarasriwong, Oraphin, Dorwart, Tanis J., Morales, Theodore Habarth, Maggio, Stephanie F., Settle, Aspen L., Milcarek, Andrew T., Alpaugh, Mary L., Theodoraki, Maria A., Theodorakis, Emmanuel A.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 2.37 MB

english, 2019

8

The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo

Gao, Xiaoxiao, Yao, Hongzhi, Mu, Yu, Guan, Peipei, Li, Guiding, Lin, Bin, Jiang, Yi, Han, Li, Huang, Xueshi, Jiang, Chenglin

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.65 MB

english, 2019

9

Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents

El-Sayed, Nehad Abou-Elmagd, Farag, Awatef El-Said, Ezzat, Manal Abdel Fattah, Akincioglu, Hulya, Gülçin, İlhami, Abou-Seri, Sahar Mahmoud

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.96 MB

english, 2019

10

Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors

Sana, Sravani, Tokala, Ramya, Bajaj, Deepti Madanlal, Nagesh, Narayana, Bokara, Kiran Kumar, Kiranmai, Gaddam, Lakshmi, Uppu Jaya, Vadlamani, Swapna, Talla, Venu, Shankaraiah, Nagula

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 8.58 MB

english, 2019

11

Design, synthesis and preliminary in-vitro studies of novel boronated monocarbonyl analogues of Curcumin (BMAC) for antitumor and β-amiloyd disaggregation activity

Azzi, Emanuele, Alberti, Diego, Parisotto, Stefano, Oppedisano, Alberto, Protti, Nicoletta, Altieri, Saverio, Geninatti-Crich, Simonetta, Deagostino, Annamaria

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.22 MB

english, 2019

12

Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II

Fouda, Ahmed M., Assiri, Mohammed A., Mora, Ahmed, Ali, Tarik E., Afifi, Tarek H., El-Agrody, Ahmed M.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.45 MB

english, 2019

13

Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach

Dorababu, Atukuri

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 23.22 MB

english, 2019

14

Exploration of Pd-catalysed four-component tandem reaction for one-pot assembly of pyrazolo[1,5-c]quinazolines as potential EGFR inhibitors

Ansari, Arshad J., Joshi, Gaurav, Yadav, Umesh Prasad, Maurya, Antim K., Agnihotri, Vijai K., Kalra, Sourav, Kumar, Raj, Singh, Sandeep, Sawant, Devesh M.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 5.91 MB

english, 2019

15

Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues

Zhao, Zefeng, Liu, Guangxin, Meng, Yufeng, Tian, Jiale, Chen, Xufei, Shen, Meilun, Li, Yuexuan, Li, Bingyao, Gao, Cong, Wu, Shaoping, Li, Cuiqin, He, Xirui, Jiang, Ru, Qian, Mingcheng, Zheng, Xiaohui

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 5.00 MB

english, 2019

16

Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture

Kwon, Jeong Eun, Lee, Yeong-Geun, Kang, Ji-Hun, Bai, Yun-Feng, Jeong, Yong Joon, Baek, Nam-In, Seo, Young-Jin, Kang, Se Chan

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.10 MB

english, 2019

17

Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine N-benzylpiperidine fragments

Zhou, Yeheng, Sun, Wei, Peng, Jiale, Yan, Hui, Zhang, Li, Liu, Xingyong, Zuo, Zhili

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.54 MB

english, 2019

18

Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells

Ragab, Fatma A.F., Abdel-Aziz, Salah A., Kamel, Marwa, Ouf, Abdelsalam Mohamed A., Allam, Heba Abdelrasheed

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 3.31 MB

english, 2019

19

Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κB-mediated transcription in HepG2 hepatoma cells

Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Paluszczak, Jarosław, Szaefer, Hanna, Narożna, Maria, Zaprutko, Lucjusz, Baer-Dubowska, Wanda

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 2.88 MB

english, 2019

20

Synthesis of novel nitroreductase enzyme-activated nitric oxide prodrugs to site-specifically kill bacteria

Hibbard, Hailey A.J., Reynolds, Melissa M.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 989 KB

english, 2019

21

New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer’s disease

Cai, Rong, Wang, Li-Ning, Fan, Jing-Jing, Geng, Shang-Qi, Liu, Yu-Ming

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.32 MB

english, 2019

22

Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma

Wei, Wen-Jun, Qi, Weiyan, Gao, Xin-Mei, Feng, Ke-Na, Ma, Kai-Liang, Li, Hang-Ying, Li, Ya, Gao, Kun

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 2.44 MB

english, 2019

23

Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides

Giuliani, Marta, Faroldi, Federica, Morelli, Laura, Torre, Enza, Lombardi, Grazia, Fallarini, Silvia, Sansone, Francesco, Compostella, Federica

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.08 MB

english, 2019

24

Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1

Wang, Qiqi, Zhang, Qingzhe, Luan, Shanshan, Yang, Kaiyin, Zheng, Mengzhu, Li, Kezhen, Chen, Lixia, Li, Hua

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 5.54 MB

english, 2019

25

Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line

Ahagh, Mina Hanifeh, Dehghan, Gholamreza, Mehdipour, Maryam, Teimuri-Mofrad, Reza, Payami, Elmira, Sheibani, Nader, Ghaffari, Maryam, Asadi, Milad

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 6.14 MB

english, 2019

26

Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22

Liang, Zhao-Yang, Shen, Nan-Xing, Zheng, Yao-Yao, Wu, Jin-Tao, Miao, Li, Fu, Xiu-Mei, Chen, Min, Wang, Chang-Yun

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 843 KB

english, 2019

27

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors

Mo, Jun, Yang, Hongyu, Chen, Tingkai, Li, Qihang, Lin, Hongzhi, Feng, Feng, Liu, Wenyuan, Qu, Wei, Guo, Qinglong, Chi, Heng, Chen, Yao, Sun, Haopeng

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 4.32 MB

english, 2019

28

Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors

Abdel-Maksoud, Mohammed S., Ammar, Usama M., El-Gamal, Mohammed I., Gamal El-Din, Mahmoud M., Mersal, Karim I., Ali, Eslam M.H., Yoo, Kyung Ho, Lee, Kyung-Tae, Oh, Chang-Hyun

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.08 MB

english, 2019

29

Phenylpropanoid and dibenzofuran derivatives from Crataegus pinnatifida with antiproliferative activities on hepatoma cells

Zhao, Peng, Guo, Rui, Zhang, Yang-Yang, Zhang, Hao, Yao, Guo-Dong, Lin, Bin, Wang, Xiao-Bo, Huang, Xiao-Xiao, Song, Shao-Jiang

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.19 MB

english, 2019

30

Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes

Bahadır Acıkara, Özlem, Ilhan, Mert, Kurtul, Ekin, Šmejkal, Karel, Küpeli Akkol, Esra

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 969 KB

english, 2019

31

STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis

Jang, Hyun-Jae, Lim, Hyung-Jin, Park, Eun-Jae, Lee, Seung-Jae, Lee, Soyoung, Lee, Seung Woong, Rho, Mun-Chual

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 2.04 MB

2019

32

Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents

Ansari, Mahsa, Shokrzadeh, Mohammad, Karima, Saeed, Rajaei, Shima, Hashemi, Seyedeh Mahdieh, Mirzaei, Hassan, Fallah, Marjan, Emami, Saeed

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 4.96 MB

2019

33

Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes

Chantarasriwong, Oraphin, Dorwart, Tanis J., Morales, Theodore Habarth, Maggio, Stephanie F., Settle, Aspen L., Milcarek, Andrew T., Alpaugh, Mary L., Theodoraki, Maria A., Theodorakis, Emmanuel A.

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 2.37 MB

2019

34

The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo

Gao, Xiaoxiao, Yao, Hongzhi, Mu, Yu, Guan, Peipei, Li, Guiding, Lin, Bin, Jiang, Yi, Han, Li, Huang, Xueshi, Jiang, Chenglin

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 4.65 MB

2019

35

Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents

El-Sayed, Nehad Abou-Elmagd, Farag, Awatef El-Said, Ezzat, Manal Abdel Fattah, Akincioglu, Hulya, Gülçin, İlhami, Abou-Seri, Sahar Mahmoud

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 1.96 MB

2019

36

Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors

Sana, Sravani, Tokala, Ramya, Bajaj, Deepti Madanlal, Nagesh, Narayana, Bokara, Kiran Kumar, Kiranmai, Gaddam, Lakshmi, Uppu Jaya, Vadlamani, Swapna, Talla, Venu, Shankaraiah, Nagula

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 8.58 MB

2019

37

Design, synthesis and preliminary in-vitro studies of novel boronated monocarbonyl analogues of Curcumin (BMAC) for antitumor and β-amiloyd disaggregation activity

Azzi, Emanuele, Alberti, Diego, Parisotto, Stefano, Oppedisano, Alberto, Protti, Nicoletta, Altieri, Saverio, Geninatti-Crich, Simonetta, Deagostino, Annamaria

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 1.22 MB

2019

38

Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II

Fouda, Ahmed M., Assiri, Mohammed A., Mora, Ahmed, Ali, Tarik E., Afifi, Tarek H., El-Agrody, Ahmed M.

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 4.45 MB

2019

39

Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach

Dorababu, Atukuri

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 23.22 MB

2019

40

Exploration of Pd-catalysed four-component tandem reaction for one-pot assembly of pyrazolo[1,5-c]quinazolines as potential EGFR inhibitors

Ansari, Arshad J., Joshi, Gaurav, Yadav, Umesh Prasad, Maurya, Antim K., Agnihotri, Vijai K., Kalra, Sourav, Kumar, Raj, Singh, Sandeep, Sawant, Devesh M.

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 5.91 MB

2019

41

Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues

Zhao, Zefeng, Liu, Guangxin, Meng, Yufeng, Tian, Jiale, Chen, Xufei, Shen, Meilun, Li, Yuexuan, Li, Bingyao, Gao, Cong, Wu, Shaoping, Li, Cuiqin, He, Xirui, Jiang, Ru, Qian, Mingcheng, Zheng, Xiaohui

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 5.00 MB

2019

42

Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture

Kwon, Jeong Eun, Lee, Yeong-Geun, Kang, Ji-Hun, Bai, Yun-Feng, Jeong, Yong Joon, Baek, Nam-In, Seo, Young-Jin, Kang, Se Chan

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 1.10 MB

2019

43

Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine N-benzylpiperidine fragments

Zhou, Yeheng, Sun, Wei, Peng, Jiale, Yan, Hui, Zhang, Li, Liu, Xingyong, Zuo, Zhili

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 4.54 MB

2019

44

Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells

Ragab, Fatma A.F., Abdel-Aziz, Salah A., Kamel, Marwa, Ouf, Abdelsalam Mohamed A., Allam, Heba Abdelrasheed

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 3.31 MB

2019

45

Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κB-mediated transcription in HepG2 hepatoma cells

Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Paluszczak, Jarosław, Szaefer, Hanna, Narożna, Maria, Zaprutko, Lucjusz, Baer-Dubowska, Wanda

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 2.88 MB

2019

46

Synthesis of novel nitroreductase enzyme-activated nitric oxide prodrugs to site-specifically kill bacteria

Hibbard, Hailey A.J., Reynolds, Melissa M.

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 989 KB

2019

47

New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer’s disease

Cai, Rong, Wang, Li-Ning, Fan, Jing-Jing, Geng, Shang-Qi, Liu, Yu-Ming

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 1.32 MB

2019

48

Extending the γ-class carbonic anhydrases inhibition profiles with phenolic compounds

Nocentini, Alessio, Osman, Sameh M., Del Prete, Sonia, Capasso, Clemente, ALOthman, Zeid A., Supuran, Claudiu T.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.34 MB

english, 2019

49

A mass spectrometric stochastic dynamic diffusion approach to selective quantitative and 3D structural analyses of native cyclodextrins by electrospray ionization and atmospheric pressure chemical ionization methods

Ivanova, Bojidarka, Spiteller, Michael

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 4.05 MB

2019

50

A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions

Tabatabaei Dakhili, Seyed Amirhossein, Pérez, David J., Gopal, Keshav, Tabatabaei Dakhili, Seyed Yasin, Ussher, John R., Velázquez-Martínez, Carlos A.

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 3.40 MB

english, 2019

51

Lyophilized extracts from vegetable flours as valuable alternatives to purified oxygenases for the synthesis of oxylipins

Sanfilippo, Claudia, Paterna, Angela, Biondi, Daniela M., Patti, Angela

Journal:

Bioorganic Chemistry

Year:

2019

Language:

english

File:

PDF, 713 KB

english, 2019

52

Editorial Board

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 50 KB

2019

53

Issue TOC

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 3.53 MB

2019

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