Volume 154; Issue 7

British Journal of Pharmacology

Volume 154; Issue 7

1

The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 403 KB

english, 2008

2

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

G Michael, K A Kane, S J Coker

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 307 KB

english, 2008

3

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

H R Lu, E Vlaminckx, A N Hermans, J Rohrbacher, K Van Ammel, R Towart, M Pugsley, D J Gallacher

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 466 KB

english, 2008

4

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres

K Sakamoto, H Mikami, J Kimura

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

5

In vitro models of proarrhythmia

C L Lawrence, C E Pollard, T G Hammond, J-P Valentin

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

6

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

C E Pollard, J-P Valentin, T G Hammond

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 121 KB

english, 2008

7

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

J J Lynch III, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox, S W Mittelstadt

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

8

Moving towards better predictors of drug-induced torsades de pointes

A S Bass, B Darpo, J-P Valentin, P Sager, K Thomas

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 119 KB

english, 2008

9

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 97 KB

english, 2008

10

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

M J Forrest, D Bloomfield, R J Briscoe, P N Brown, A-M Cumiskey, J Ehrhart, J C Hershey, W J Keller, X Ma, H E McPherson, E Messina, L B Peterson, W Sharif-Rodriguez, P K S Siegl, P J Sinclair, C P Sp

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 338 KB

english, 2008

11

Cellular basis of drug-induced torsades de pointes

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 113 KB

english, 2008

12

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 353 KB

english, 2008

13

The failure of torcetrapib: what have we learned?

T R Joy, R A Hegele

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 64 KB

english, 2008

14

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery

T P Barros, W K Alderton, H M Reynolds, A G Roach, S Berghmans

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 290 KB

english, 2008

15

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction

H J Van Der Linde, B Van Deuren, A Teisman, R Towart, D J Gallacher

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 334 KB

english, 2008

16

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

X Yao, D L Anderson, S A Ross, D G Lang, B Z Desai, D C Cooper, P Wheelan, M S McIntyre, M L Bergquist, K I MacKenzie, J D Becherer, M A Hashim

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 276 KB

english, 2008

17

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

T M Haushalter, G S Friedrichs, D L Reynolds, M Barecki-Roach, G Pastino, R Hayes, A S Bass

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 206 KB

english, 2008

18

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes

A S Bass, B Darpo, A Breidenbach, K Bruse, H S Feldman, D Garnes, T Hammond, W Haverkamp, C January, J Koerner, C Lawrence, D Leishman, D Roden, J P Valentin, M A Vos, Y-Y Zhou, T Karluss, P Sager

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 142 KB

english, 2008

19

Principles of Safety Pharmacology

M K Pugsley, S Authier, M J Curtis

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 256 KB

english, 2008

20

Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 118 KB

english, 2008