Volume 69; Issue 6

Cancer Chemotherapy and Pharmacology

Volume 69; Issue 6

1

The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens

Lamas, M. J., Duran, G., Balboa, E., Bernardez, B., Candamio, S., Vidal, Y., Mosquera, A., Giraldez, J. M., Lopez, R., Carracedo, A., Barros, F.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 279 KB

english, 2012

2

Ascorbic acid and healthy lymphocytes: a way to explain anticancer activity?

Rodemeister, Sandra, Nohr, Donatus, Biesalski, Hans K.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 112 KB

english, 2012

3

Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+hematological malignancies

Bose, Prithviraj, Perkins, Edward B., Honeycut, Connie, Wellons, Martha D., Stefan, Tammy, Jacobberger, James W., Kontopodis, Emmanouil, Beumer, Jan H., Egorin, Merrill J., Imamura, Chiyo K., Douglas

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 314 KB

english, 2012

4

FDG-PET as a pharmacodynamic biomarker for early assessment of treatment response to linifanib (ABT-869) in a non-small cell lung cancer xenograft model

Mudd, Sarah R., Voorbach, Martin J., Reuter, David R., Tapang, Paul, Hickson, Jonathan A., Refici-Buhr, Marion, Fox, Gerard B., Albert, Daniel H., Luo, Yanping, Day, Mark

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 237 KB

english, 2012

5

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity

Al Safarjalani, Omar N., Rais, Reem, Naguib, Fardos N. M., el Kouni, Mahmoud H.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 202 KB

english, 2012

6

A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults

Boni, Joseph P., Leister, Cathie, Hug, Bruce, Burns, Jaime, Sonnichsen, Daryl

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 406 KB

english, 2012

7

An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors

Asahina, Hajime, Tamura, Yosuke, Nokihara, Hiroshi, Yamamoto, Noboru, Seki, Yoshitaka, Shibata, Takashi, Goto, Yasushi, Tanioka, Maki, Yamada, Yasuhide, Coates, Andrew, Chiu, Yi-Lin, Li, Xiaohui, Prad

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 368 KB

english, 2012

8

Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas

Dong, Mei, Ning, Zhi-Qiang, Xing, Pu-Yuan, Xu, Jia-Lian, Cao, Hai-Xiang, Dou, Gui-Fang, Meng, Zhi-Yun, Shi, Yuan-Kai, Lu, Xian-Ping, Feng, Feng-Yi

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 472 KB

english, 2012

9

The administration of gefitinib in patients with advanced non-small-cell lung cancer after the failure of erlotinib

Grossi, Francesco, Rijavec, Erika, Dal Bello, Maria Giovanna, Defferrari, Carlotta, Brianti, Annalisa, Barletta, Giulia, Genova, Carlo, Murolo, Carmelina, Cosso, Maurizio, Fontanini, Gabriella, Boldri

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 176 KB

english, 2012

10

The T393C polymorphism ofGNAS1as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum

Xie, Fa-Jun, Zhao, Peng, Kou, Jun-Yan, Hong, Wei, Fu, Li, Hu, Lin, Hong, Dan, Su, Dan, Gao, Yun, Zhang, Yi-Ping

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 311 KB

english, 2012

11

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study

Jansen, Robert S., Rosing, Hilde, Wijermans, Pierre W., Keizer, Ron J., Schellens, Jan H. M., Beijnen, Jos H.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

12

Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent

Rayburn, Elizabeth, Wang, Wei, Li, Mao, Zhang, Xu, Xu, Hongxia, Li, Haibo, Qin, Jiang-Jiang, Jia, Lee, Covey, Joseph, Lee, Moses, Zhang, Ruiwen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 533 KB

english, 2012

13

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules

Liu, Qian, Sun, Jessica D., Wang, Jingli, Ahluwalia, Dharmendra, Baker, Amanda F., Cranmer, Lee D., Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W. Steve, Curd, John G., Matteucci, Mark D., Har

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 413 KB

english, 2012

14

Neoadjuvant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for esophageal cancer

Emi, Manabu, Hihara, Jun, Hamai, Yoichi, Aoki, Yoshiro, Okada, Morihito, Kenjo, Masahiro, Murakami, Yuji

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 200 KB

english, 2012

15

Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients

Reardon, David A., Conrad, Charles A., Cloughesy, Timothy, Prados, Michael D., Friedman, Henry S., Aldape, Kenneth D., Mischel, Paul, Xia, Jane, DiLea, Clifford, Huang, Jerry, Mietlowski, William, Dug

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 416 KB

english, 2012

16

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, Aaron M., Gallardo, Jose L., Bedi, Jessica, Giri, Rajan, Benoit, Adam R., Olin, Michael R., Morizio, Kate M., Ohlfest, John R., Remmel, Rory P., Ferguson, David M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 512 KB

english, 2012

17

Phase I dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors

Calvo, E., Vermorken, J. B., Hiret, S., Rodon, J., Cortes, J., Senellart, H., den Brande, J., Dyck, J., Pétain, A., Ferre, P., Bennouna, J.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 242 KB

english, 2012

18

Phase I trial of irinotecan and amrubicin with granulocyte colony-stimulating factor support in extensive-stage small-cell lung cancer

Asakuma, Maiko, Yamamoto, Michiko, Wada, Mayuko, Ryuge, Shinichiro, Katono, Ken, Yokoba, Masanori, Fukui, Tomoya, Takakura, Akira, Otani, Sakiko, Maki, Sachiyo, Igawa, Satoshi, Yanaihara, Tomoko, Mits

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 196 KB

english, 2012

19

Transient elevation of serum cystatin C concentrations during perioperative cisplatin-based chemotherapy in esophageal cancer patients

Kume, Manabu, Yasui, Hiroyuki, Yoshikawa, Yutaka, Horinouchi, Masanori, Higashiguchi, Kanae, Kobayashi, Yoko, Kuroda, Daisuke, Hirano, Takeshi, Hirai, Midori, Nakamura, Tsutomu

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 542 KB

english, 2012

20

Reply

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 123 KB

english, 2012

21

The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells

Takeba, Yuko, Matsumoto, Naoki, Watanabe, Minoru, Takenoshita-Nakaya, Sachiko, Ohta, Yuki, Kumai, Toshio, Takagi, Masayuki, Koizumi, Satoshi, Asakura, Takeshi, Otsubo, Takehito

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 792 KB

english, 2012

22

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

Xia, Binfeng, Heimbach, Tycho, Lin, Tsu-han, He, Handan, Wang, Yanfeng, Tan, Eugene

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 595 KB

english, 2012

23

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin

Grosso, Federica, D’Incalci, Maurizio, Cartoafa, Mirela, Nieto, Antonio, Fernández-Teruel, Carlos, Alfaro, Vicente, Lardelli, Pilar, Roy, Elena, Gómez, Javier, Kahatt, Carmen, Soto-Matos, Arturo, Juds

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 289 KB

english, 2012

24

Open-label, phase I, pharmacokinetic studies of abiraterone acetate in healthy men

Acharya, M., Bernard, A., Gonzalez, M., Jiao, J., Vries, R., Tran, N.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 304 KB

english, 2012

25

Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines

Mueller, Annett, Bachmann, Erika, Linnig, Monika, Khillimberger, Katrin, Schimanski, Carl Christoph, Galle, Peter R., Moehler, Markus

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 835 KB

english, 2012

26

A phase I trial of concurrent chemoradiotherapy with non-split administration of docetaxel and cisplatin for dry stage III non-small-cell lung cancer (JCOG9901DI)

Hida, Naoya, Okamoto, Hiroaki, Misumi, Yuuki, Sato, Akira, Ishii, Mari, Kashizaki, Fumihiro, Shimokawa, Tsuneo, Shimizu, Teppei, Watanabe, Koshiro

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 218 KB

english, 2012

27

An SNP inCYP39A1is associated with severe neutropenia induced by docetaxel

Uchiyama, Toshitaka, Kanno, Hitoshi, Ishitani, Ken, Fujii, Hisaichi, Ohta, Hiroaki, Matsui, Hideo, Kamatani, Naoyuki, Saito, Kayoko

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

28

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Liu, Ziwei, Yuan, Qianying, Zhang, Xuenong, Xiong, Chaomei, Xue, Pingping, Ruan, Jinlan

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 637 KB

english, 2012

29

Lenalidomide in solid tumors

Segler, Angela, Tsimberidou, Apostolia-Maria

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 294 KB

english, 2012

30

FOLFIRI as second-line chemotherapy for advanced pancreatic cancer: a GISCAD multicenter phase II study

Zaniboni, Alberto, Aitini, Enrico, Barni, Sandro, Ferrari, Daris, Cascinu, Stefano, Catalano, Vincenzo, Valmadre, Giuseppe, Ferrara, Domenica, Veltri, Enzo, Codignola, Claudio, Labianca, Roberto

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 179 KB

english, 2012

31

Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: evidence from retrospective studies

Wang, Zhen-Hua, Gao, Qin-Yan, Fang, Jing-Yuan

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 361 KB

english, 2012