Volume 5; Issue 3

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Cancer Discovery
Volume 5; Issue 3

Cancer Discovery

Volume 5; Issue 3

1

EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

Miao, B., Ji, Z., Tan, L., Taylor, M., Zhang, J., Choi, H. G., Frederick, D. T., Kumar, R., Wargo, J. A., Flaherty, K. T., Gray, N. S., Tsao, H.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

2

JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

Kleppe, M., Kwak, M., Koppikar, P., Riester, M., Keller, M., Bastian, L., Hricik, T., Bhagwat, N., McKenney, A. S., Papalexi, E., Abdel-Wahab, O., Rampal, R., Marubayashi, S., Chen, J. J., Romanet, V.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

3

Predicting Cancer Drug Response: Advancing the DREAM

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 1.30 MB

english, 2015

4

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

Li, Y., Chitnis, N., Nakagawa, H., Kita, Y., Natsugoe, S., Yang, Y., Li, Z., Wasik, M., Klein-Szanto, A. J. P., Rustgi, A. K., Diehl, J. A.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 6.19 MB

english, 2015

5

A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors

Van Rechem, C., Black, J. C., Greninger, P., Zhao, Y., Donado, C., Burrowes, P. d., Ladd, B., Christiani, D. C., Benes, C. H., Whetstine, J. R.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 2.06 MB

english, 2015

6

Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas

Hammerman, P. S., Hayes, D. N., Grandis, J. R.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 2.02 MB

english, 2015

7

Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth

Ran, L., Sirota, I., Cao, Z., Murphy, D., Chen, Y., Shukla, S., Xie, Y., Kaufmann, M. C., Gao, D., Zhu, S., Rossi, F., Wongvipat, J., Taguchi, T., Tap, W. D., Mellinghoff, I. K., Besmer, P., Antonescu

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 6.49 MB

english, 2015

8

A CD19L-sTRAIL Fusion Targets B-cell Precursor Acute Lymphoblastic Leukemia

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 372 KB

english, 2015

9

Targeting ETV1 in Gastrointestinal Stromal Tumors: Tripping the Circuit Breaker in GIST?

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 391 KB

english, 2015

10

From Histones to Ribosomes: A Chromatin Regulator Tangoes with Translation

Rothbart, S. B., Dickson, B. M., Strahl, B. D.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 539 KB

english, 2015

11

Aberrant Cytokine Production by Nonmalignant Cells in the Pathogenesis of Myeloproliferative Tumors and Response to JAK Inhibitor Therapies

Belver, L., Ferrando, A. A.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 439 KB

english, 2015

12

Ligand-Independent EPHA2 Signaling Drives the Adoption of a Targeted Therapy-Mediated Metastatic Melanoma Phenotype

Paraiso, K. H. T., Thakur, M. D., Fang, B., Koomen, J. M., Fedorenko, I. V., John, J. K., Tsao, H., Flaherty, K. T., Sondak, V. K., Messina, J. L., Pasquale, E. B., Villagra, A., Rao, U. N., Kirkwood,

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 5.53 MB

english, 2015

13

AKT Impairs NHEJ by Phosphorylating XLF

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 372 KB

english, 2015

14

Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis

Van Rechem, C., Black, J. C., Boukhali, M., Aryee, M. J., Graslund, S., Haas, W., Benes, C. H., Whetstine, J. R.

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 2.21 MB

english, 2015

15

In This Issue

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 5.61 MB

english, 2015

16

MONDOA Is Required for MYC-Driven Metabolic Changes

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 378 KB

english, 2015

17

DNA PoL Suppresses HR and Is Required for HR-Deficient Cell Survival

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 488 KB

english, 2015

18

Correction: Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 279 KB

english, 2015

19

Protein Kinase C Isozymes Are Tumor Suppressors

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 474 KB

english, 2015

20

mTOR Signaling Regulates DROSHA Stability and miRNA Biogenesis

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 442 KB

english, 2015

21

IOM Report Calls for Culture of Data Sharing

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 661 KB

english, 2015

22

BCL2 Is Synthetic Lethal to IDH1/2 Mutations in AML

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 520 KB

english, 2015

23

Olaparib Approved for Advanced Ovarian Cancer

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 454 KB

english, 2015

24

Antioxidant Pathways Cooperate to Induce Tumorigenesis

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 378 KB

english, 2015

25

Next Steps for Cancer Immune Therapy

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 473 KB

english, 2015

26

AACR, ASCO Call for E-cigarette Regulation

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 549 KB

english, 2015

27

By the Numbers: Drugs Approved by the FDA, 2005-2014

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 337 KB

english, 2015

28

Heparin Is an Activating ALK Ligand

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 512 KB

english, 2015

29

Organoid Model Advances Pancreatic Cancer Research

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 748 KB

english, 2015

30

People

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 486 KB

english, 2015

31

Noted

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 369 KB

english, 2015

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