Volume 7; Issue 2

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Cancer Discovery
Volume 7; Issue 2

Cancer Discovery

Volume 7; Issue 2

1

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers

Olsen, Sarah Naomi, Wronski, Ania, Castaño, Zafira, Dake, Benjamin, Malone, Clare, De Raedt, Thomas, Enos, Miriam, DeRose, Yoko S., Zhou, Wenhui, Guerra, Stephanie, Loda, Massimo, Welm, Alana, Partrid

Journal:

Cancer Discovery

Year:

2017

File:

PDF, 3.44 MB

2017

2

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

Demaria, Marco, O'Leary, Monique N., Chang, Jianhui, Shao, Lijian, Liu, Su, Alimirah, Fatouma, Koenig, Kristin, Le, Catherine, Mitin, Natalia, Deal, Allison M., Alston, Shani, Academia, Emmeline C., K

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

3

The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis

Goddard, Erica T., Hill, Ryan C., Nemkov, Travis, D'Alessandro, Angelo, Hansen, Kirk C., Maller, Ori, Mongoue-Tchokote, Solange, Mori, Motomi, Partridge, Ann H., Borges, Virginia F., Schedin, Pepper

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.42 MB

english, 2017

4

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax

Montero, Joan, Stephansky, Jason, Cai, Tianyu, Griffin, Gabriel K., Cabal-Hierro, Lucia, Togami, Katsuhiro, Hogdal, Leah J., Galinsky, Ilene, Morgan, Elizabeth A., Aster, Jon C., Davids, Matthew S., L

Journal:

Cancer Discovery

Year:

2017

File:

PDF, 691 KB

2017

5

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

Sansregret, Laurent, Patterson, James O., Dewhurst, Sally, López-García, Carlos, Koch, André, McGranahan, Nicholas, Chao, William Chong Hang, Barry, David J., Rowan, Andrew, Instrell, Rachael, Horswel

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 3.51 MB

english, 2017

6

Targeting ALK: Precision Medicine Takes on Drug Resistance

Lin, Jessica J., Riely, Gregory J., Shaw, Alice T.

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 3.85 MB

english, 2017

7

Tuning Chromosomal Instability to Optimize Tumor Fitness

Burkard, Mark E., Weaver, Beth A.

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 497 KB

english, 2017

8

Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers

Sears, Rosalie, Gray, Joe W.

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

9

JAK Mutations as Escape Mechanisms to Anti–PD-1 Therapy

Marabelle, Aurelien, Aspeslagh, Sandrine, Postel-Vinay, Sophie, Soria, Jean-Charles

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

10

BLU-285, DCC-2618 Show Activity against GIST

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 493 KB

english, 2017

11

Anti-CD22 CAR Therapy Leads to ALL Remissions

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 290 KB

english, 2017

12

Nerve Growth Factor Drives Gastric Tumorigenesis via Acetylcholine

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

13

Abemaciclib Shows Promise for Early Breast Cancer

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

14

Rucaparib Approved for Ovarian Cancer

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 442 KB

english, 2017

15

Nivolumab plus Ipilimumab Is Well Tolerated and Active in NSCLC

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

16

Pancreatic Tumors Exhibit Enhanced Extracellular Protein Catabolism

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

17

Reversible Epigenetic Changes Create Refractory Glioblastoma Stem Cells

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

18

The KRAS Membrane Anchor Regulates Signaling through Lipid Specificity

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 659 KB

english, 2017

19

Project GENIE Goes Public

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.03 MB

english, 2017

20

By the Numbers: New Biologic License Application Filings and Drug Approvals, 2007–2016

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 418 KB

english, 2017

21

Stabilization of Wild-Type MLL Displaces Oncogenic MLL Fusion Proteins

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 518 KB

english, 2017

22

The Cytoplasmic Sensor NLRC3 Inhibits mTOR Signaling in Tumors

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 704 KB

english, 2017

23

Tissues from Young Mice and Patients Are Primed for Apoptosis

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 518 KB

english, 2017

24

Benefit Mixed with Caution for Buparlisib

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 418 KB

english, 2017

25

IMGN853 Is Active in Patients with FRα-Positive Ovarian Cancer

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 659 KB

english, 2017

26

PPP2R3B Is a Sex-Linked Melanoma Tumor Suppressor Gene

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 704 KB

english, 2017

27

“Cures” Act Signed into Law

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

28

In This Issue

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 4.67 MB

english, 2017

29

Noted

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 388 KB

english, 2017