Volume 24; Issue 9

Chemical Research in Toxicology

Volume 24; Issue 9

1

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Stepan, Antonia F., Walker, Daniel P., Bauman, Jonathan, Price, David A., Baillie, Thomas A., Kalgutkar, Amit S., Aleo, Michael D.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.56 MB

english, 2011

2

Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation

Fritz, Kristofer S., Petersen, Dennis R.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 918 KB

english, 2011

3

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

Meanwell, Nicholas A.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.74 MB

english, 2011

4

Experimental and Theoretical Investigations of the Autoxidation of Geranial: A Dioxolane Hydroperoxide Identified as a Skin Sensitizer

Hagvall, Lina, Bäcktorp, Carina, Norrby, Per-Ola, Karlberg, Ann-Therese, Börje, Anna

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 916 KB

english, 2011

5

Characterization of Dibenzo[ a,l ]pyrene- trans -11,12-diol (Dibenzo[ def,p ]chrysene) Glucuronidation by UDP-Glucuronosyltransferases

Olson, Kristine C., Sun, Dongxiao, Chen, Gang, Sharma, Arun K., Amin, Shantu, Ropson, Ira J., Spratt, Thomas E., Lazarus, Philip

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

6

Cytotoxicity and Genotoxicity of Size-Fractionated Iron Oxide (Magnetite) in A549 Human Lung Epithelial Cells: Role of ROS, JNK, and NF-κB

Könczöl, Mathias, Ebeling, Sandra, Goldenberg, Ella, Treude, Fabian, Gminski, Richard, Gieré, Reto, Grobéty, Bernard, Rothen-Rutishauser, Barbara, Merfort, Irmgard, Mersch-Sundermann, Volker

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 5.01 MB

english, 2011

7

Quantitative Analysis of Trihydroxybutyl Mercapturic Acid, a Urinary Metabolite of 1,3-Butadiene, in Humans

Kotapati, Srikanth, Matter, Brock A., Grant, Amy L., Tretyakova, Natalia Y.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

8

Dynamic Changes of Acoustic Load and Complex Impedance as Reporters for the Cytotoxicity of Small Molecule Inhibitors

Tarantola, Marco, Sunnick, Eva, Schneider, David, Marel, Anna-Kristina, Kunze, Angelika, Janshoff, Andreas

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.88 MB

english, 2011

9

Comparing Next-Generation Sequencing and Microarray Technologies in a Toxicological Study of the Effects of Aristolochic Acid on Rat Kidneys

Su, Zhenqiang, Li, Zhiguang, Chen, Tao, Li, Quan-Zhen, Fang, Hong, Ding, Don, Ge, Weigong, Ning, Baitang, Hong, Huixiao, Perkins, Roger G., Tong, Weida, Shi, Leming

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

10

The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation

Korashy, Hesham M., Anwar-Mohamed, Anwar, Soshilov, Anatoly A., Denison, Michael S., El-Kadi, Ayman O.S.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 2.27 MB

english, 2011

11

DFT Study on the Radical Anions Formed by Primaquine and Its Derivatives

Liu, Haining, Walker, Larry A., Doerksen, Robert J.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.41 MB

english, 2011

12

Preclinical Genotoxicology of Nor-β-lapachone in Human Cultured Lymphocytes and Chinese Hamster Lung Fibroblasts

Cavalcanti, Bruno C., Barros, Francisco W. A., Cabral, Igor O., Ferreira, José R. O., Magalhães, Hemerson I. F., Júnior, Hélio V. N., da Silva Júnior, Eufrânio N., de Abreu, Fabiane C., Costa, C

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 2.84 MB

english, 2011

13

In This Issue

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.16 MB

english, 2011

14

Spotlight

Rouzer, Carol A.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 737 KB

english, 2011

15

Quantification of 4-Beta-Hydroxycholesterol in Human Plasma Using Automated Sample Preparation and LC-ESI-MS/MS Analysis

Goodenough, Angela K., Onorato, Joelle M., Ouyang, Zheng, Chang, Shu, Rodrigues, A. David, Kasichayanula, Sreeneeranj, Huang, Shu-Pang, Turley, Wesley, Burrell, Richard, Bifano, Marc, Jemal, Mohammed,

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

16

Metabolic Detoxication Pathways for Sterigmatocystin in Primary Tracheal Epithelial Cells: Structural Identification of Glutathione Adducts

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 803 KB

english, 2011

17

Enhanced Toxicity of the Protein Cross-Linkers Divinyl Sulfone and Diethyl Acetylenedicarboxylate in Comparison to Related Monofunctional Electrophiles

West, James D., Stamm, Chelsea E., Brown, Haley A., Justice, Samantha L., Morano, Kevin A.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 2.58 MB

english, 2011

18

Comparative Toxicity of Arsenic Metabolites in Human Bladder Cancer EJ-1 Cells

Naranmandura, Hua, Carew, Michael W., Xu, Shi, Lee, Jane, Leslie, Elaine M., Weinfeld, Michael, Le, X. Chris

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.64 MB

english, 2011

19

Structural Determinant of Chemical Reactivity and Potential Health Effects of Quinones from Natural Products

Tu, Tingting, Giblin, Daryl, Gross, Michael L.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 3.27 MB

english, 2011