Volume 25; Issue 11

Chemical Research in Toxicology

Volume 25; Issue 11

1

Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione- S -transferase P1-1

Boerma, Jan Simon, Dragovic, Sanja, Vermeulen, Nico P. E., Commandeur, Jan N. M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.98 MB

english, 2012

2

Analogues of the Epoxy Resin Monomer Diglycidyl Ether of Bisphenol F: Effects on Contact Allergenic Potency and Cytotoxicity

O'Boyle, Niamh M., Delaine, Tamara, Luthman, Kristina, Natsch, Andreas, Karlberg, Ann-Therese

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 551 KB

english, 2012

3

Development of Mechanism-Based Structural Alerts for Respiratory Sensitization Hazard Identification

Enoch, S. J., Seed, M. J., Roberts, D. W., Cronin, M. T. D., Stocks, S. J., Agius, R. M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 390 KB

english, 2012

4

Characterization of Rat Liver Proteins Adducted by Reactive Metabolites of Menthofuran

Khojasteh, S. Cyrus, Hartley, Dylan P., Ford, Kevin A., Uppal, Hirdesh, Oishi, Shimako, Nelson, Sidney D.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

5

Biocompatibility of Mesoporous Silica Nanoparticles

Asefa, Tewodros, Tao, Zhimin

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.85 MB

english, 2012

6

Correction to Functionalization Density Dependent Toxicity of Oxidized Multiwalled Carbon Nanotubes in a Murine Macrophage Cell Line

Singh, Raman Preet, Das, Manasmita, Thakare, Vivek, Jain, Sanyog

Journal:

Chemical Research in Toxicology

Year:

2012

File:

PDF, 593 KB

2012

7

Cytotoxic Effects of Jay Amin Hydroxamic Acid (JAHA), a Ferrocene-Based Class I Histone Deacetylase Inhibitor, on Triple-Negative MDA-MB231 Breast Cancer Cells

Librizzi, Mariangela, Longo, Alessandra, Chiarelli, Roberto, Amin, Jahanghir, Spencer, John, Luparello, Claudio

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.87 MB

english, 2012

8

Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1-Chloro-2-hydroxy-3-butene to 1-Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Elfarra, Adnan A., Zhang, Xin-Yu

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

9

Preventing Protein Oxidation with Sugars: Scavenging of Hypohalous Acids by 5-Selenopyranose and 4-Selenofuranose Derivatives

Storkey, Corin, Pattison, David I., White, Jonathan M., Schiesser, Carl H., Davies, Michael J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.33 MB

english, 2012

10

Biochemical Investigations into the Mutagenic Potential of 8-Oxo-2′-deoxyguanosine Using Nucleotide Analogues

Hamm, Michelle L., Crowley, Kelly A., Ghio, Michael, Lindell, Maria A. M., McFadden, Emily J., Silberg, Jordan S. L., Weaver, Amelia M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

11

Rat α-Fetoprotein Binding Affinities of a Large Set of Structurally Diverse Chemicals Elucidated the Relationships between Structures and Binding Affinities

Hong, Huixiao, Branham, William S., Dial, Stacey L., Moland, Carrie L., Fang, Hong, Shen, Jie, Perkins, Roger, Sheehan, Daniel, Tong, Weida

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.61 MB

english, 2012

12

Novel Oxidatively Activated Agents Modify DNA and Are Enhanced by Ercc1 Silencing

Jones, Amy R., Bell-Horwath, Tiffany R., Li, Guorui, Rollmann, Stephanie M., Merino, Edward J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.68 MB

english, 2012

13

In-Vitro Replication Studies on O 2 -Methylthymidine and O 4 -Methylthymidine

Andersen, Nisana, Wang, Jianshuang, Wang, Pengcheng, Jiang, Yong, Wang, Yinsheng

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.31 MB

english, 2012

14

Influence of the Length of Imogolite-Like Nanotubes on Their Cytotoxicity and Genotoxicity toward Human Dermal Cells

Liu, Wei, Chaurand, Perrine, Di Giorgio, Carole, De Méo, Michel, Thill, Antoine, Auffan, Mélanie, Masion, Armand, Borschneck, Daniel, Chaspoul, Florence, Gallice, Philippe, Botta, Alain, Bottero, Jean

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.49 MB

english, 2012

15

A Single Nuclease-Resistant Linkage in DNA as a Versatile Tool for the Characterization of DNA Lesions: Application to the Guanine Oxidative Lesion “G+34” Generated by Metalloporphyrin/KHSO 5 Reagent

Tomaszewska, Agnieszka, Mourgues, Sophie, Guga, Piotr, Nawrot, Barbara, Pratviel, Geneviève

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

16

Oxidative DNA Adducts Detected in Vitro from Redox Activity of Cigarette Smoke Constituents

Vadhanam, Manicka V., Thaiparambil, Jose, Gairola, C. Gary, Gupta, Ramesh C.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 907 KB

english, 2012

17

Cytotoxic and Proapototic Activities of Imidoselenocarbamate Derivatives Are Dependent on the Release of Methylselenol

Zuazo, Alicia, Plano, Daniel, Ansó, Elena, Lizarraga, Elena, Font, María, Martínez Irujo, Juan J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.62 MB

english, 2012

18

The Mitochondrial Amidoxime Reducing Component (mARC) Is Involved in Detoxification of N-Hydroxylated Base Analogues

Krompholz, Nina, Krischkowski, Carmen, Reichmann, Debora, Garbe-Schönberg, Dieter, Mendel, Ralf-R., Bittner, Florian, Clement, Bernd, Havemeyer, Antje

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.89 MB

english, 2012

19

Liver Specificity of the Carcinogenicity of NOCs: A Chemical–Molecular Perspective

Yuan, Jintao, Pu, Yuepu, Yin, Lihong

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 815 KB

english, 2012

20

Comparative NMR-Based Metabonomic Investigation of the Metabolic Phenotype Associated with Tienilic Acid and Tienilic Acid Isomer

Coen, Muireann, Rademacher, Peter M., Zou, Wei, Scott, Michael, Ganey, Patricia E., Roth, Robert, Nelson, Sidney D.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

21

Metabolism of Inorganic Arsenic in Intestinal Epithelial Cell Lines

Calatayud, M., Vélez, D., Devesa, V.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 502 KB

english, 2012

22

Phenylmethylsulfonyl Fluoride, a Potentiator of Neuropathy, Alters the Interaction of Organophosphorus Compounds with Soluble Brain Esterases

Mangas, Iris, Vilanova, Eugenio, Estévez, Jorge

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 872 KB

english, 2012

23

Direct-Acting DNA Alkylating Agents Present in Aqueous Extracts of Areca Nut and Its Products

Hu, Chiung-Wen, Chao, Mu-Rong

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 939 KB

english, 2012

24

In Vitro Bioactivation of a Selective Estrogen Receptor Modulator (2 S ,3 R )-(+)-3-(3-Hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol ( I ) in Liver Microsomes: Formation of Adenine Adducts

Li, Ying, Doss, George A., Li, Yan, Chen, Qing, Tang, Wei, Zhang, Zhoupeng

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.91 MB

english, 2012

25

Physiologically Based Kinetic Models for the Alkenylbenzene Elemicin in Rat and Human and Possible Implications for Risk Assessment

van den Berg, Suzanne J. P. L., Punt, Ans, Soffers, Ans E. M. F., Vervoort, Jacques, Ngeleja, Stephen, Spenkelink, Bert, Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

26

A Cysteine-Reactive Alkyl Hydroquinone Modifies Topoisomerase IIα, Enhances DNA Breakage, and Induces Apoptosis in Cancer Cells

Lin, Ting-Yu, Huang, Cheng-Po, Au, Lo-Chun, Chang, Ya-Wen, Hu, Chung-Yi, Lin, Shwu-Bin

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.71 MB

english, 2012

27

Arsenic Exposure through Drinking Water Is Associated with Longer Telomeres in Peripheral Blood

Li, Huiqi, Engström, Karin, Vahter, Marie, Broberg, Karin

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

28

Myeloperoxidase Catalyzes the Conjugation of Serotonin to Thiols via Free Radicals and Tryptamine-4,5-dione

Kato, Yoji, Peskin, Alexander V., Dickerhof, Nina, Harwood, D. Tim, Kettle, Anthony J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

29

Electrophilic Adduction of Ubiquitin Activating Enzyme E1 by N , N -Diethyldithiocarbamate Inhibits Ubiquitin Activation and Is Accompanied by Striatal Injury in the Rat

Viquez, Olga M., Caito, Samuel W., McDonald, W. Hayes, Friedman, David B., Valentine, William M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.81 MB

english, 2012

30

Solution Structure of Duplex DNA Containing a β-Carba-Fapy-dG Lesion

Lukin, Mark, Zaliznyak, Tatiana, Attaluri, Sivaprasad, Johnson, Francis, de los Santos, Carlos

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.68 MB

english, 2012

31

Quantitative Prediction of Antitarget Interaction Profiles for Chemical Compounds

Zakharov, Alexey V., Lagunin, Alexey A., Filimonov, Dmitry A., Poroikov, Vladimir V.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

32

Stability of N -Glycosidic Bond of (5′ S )-8,5′-Cyclo-2′-deoxyguanosine

Das, Rajat S., Samaraweera, Milinda, Morton, Martha, Gascón, José A., Basu, Ashis K.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.82 MB

english, 2012

33

Importance of Multi-P450 Inhibition in Drug–Drug Interactions: Evaluation of Incidence, Inhibition Magnitude, and Prediction from in Vitro Data

Isoherranen, Nina, Lutz, Justin D., Chung, Sophie P., Hachad, Houda, Levy, Rene H., Ragueneau-Majlessi, Isabelle

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

34

The Efficiencies of Damage Recognition and Excision Correlate with Duplex Destabilization Induced by Acetylaminofluorene Adducts in Human Nucleotide Excision Repair

Yeo, Jung-Eun, Khoo, Andy, Fagbemi, Adebanke F., Schärer, Orlando D.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.19 MB

english, 2012

35

Spotlight

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 754 KB

english, 2012

36

In This Issue

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

37

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

Metushi, Imir G., Nakagawa, Tetsuya, Uetrecht, Jack

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

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