Volume 25; Issue 2

Chemical Research in Toxicology

Volume 25; Issue 2

1

Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions

LoPachin, Richard M., Gavin, Terrence, DeCaprio, Anthony, Barber, David S.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1000 KB

english, 2012

2

Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones

Sridhar, Jayalakshmi, Liu, Jiawang, Foroozesh, Maryam, Klein Stevens, Cheryl L.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.42 MB

english, 2012

3

Cellular Response to Antitumor cis -Dichlorido Platinum(II) Complexes of CDK Inhibitor Bohemine and Its Analogues

Liskova, Barbora, Zerzankova, Lenka, Novakova, Olga, Kostrhunova, Hana, Travnicek, Zdenek, Brabec, Viktor

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 360 KB

english, 2012

4

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

Dansette, Patrick M., Rosi, Julien, Bertho, Gildas, Mansuy, Daniel

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

5

Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism

Mekenyan, Ovanes G., Petkov, Petko I., Kotov, Stefan V., Stoeva, Stoyanka, Kamenska, Verginia B., Dimitrov, Sabcho D., Honma, Masamitsu, Hayashi, Makoto, Benigni, Romualdo, Donner, E. Maria, Patlewicz

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

6

In Vitro Study of Transporters Involved in Intestinal Absorption of Inorganic Arsenic

Calatayud, Marta, Barrios, Julio A., Vélez, Dinoraz, Devesa, Vicenta

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 864 KB

english, 2012

7

An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity

Pfohl-Leszkowicz, Annie, Manderville, Richard A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 904 KB

english, 2012

8

Direct Analysis of 5-Methylcytosine and 5-Methyl-2′-deoxycytidine in Human Urine by Isotope Dilution LC-MS/MS: Correlations with N-Methylated Purines and Oxidized DNA Lesions

Hu, Chiung-Wen, Liu, Hung-Hsin, Li, Yi-Jie, Chao, Mu-Rong

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 324 KB

english, 2012

9

Hypothiocyanous Acid: Benign or Deadly?

Barrett, Tessa J., Hawkins, Clare L.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 694 KB

english, 2012

10

Differential Cytostatic and Cytotoxic Action of Metallocorroles against Human Cancer Cells: Potential Platforms for Anticancer Drug Development

Lim, Punnajit, Mahammed, Atif, Okun, Zoya, Saltsman, Irena, Gross, Zeev, Gray, Harry B., Termini, John

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 607 KB

english, 2012

11

Biologically Relevant Oxidants Cause Bound Proteins To Readily Oxidatively Cross-Link at Guanine

Solivio, Morwena J., Nemera, Dessalegn B., Sallans, Larry, Merino, Edward J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.23 MB

english, 2012

12

Replication Bypass of the trans -4-Hydroxynonenal-Derived (6 S ,8 R ,11 S )-1, N 2 -Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV

Banerjee, Surajit, Christov, Plamen P., Kozekova, Albena, Rizzo, Carmelo J., Egli, Martin, Stone, Michael P.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.47 MB

english, 2012

13

Synthesis and In Vivo Lead Detoxification Evaluation of Poly-α,β- dl -aspartyl- l -methionine

Zhang, Huiliang, Wang, Yuji, Zhao, Ming, Wu, Jianhui, Zhang, Xiaoyi, Gui, Lin, Zheng, Meiqing, Li, Li, Liu, Jiawang, Peng, Shiqi

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.27 MB

english, 2012

14

Selection of Monoclonal Antibodies Against 6-oxo-M 1 dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M 1 dG in Vivo

Akingbade, Dapo, Kingsley, Philip J., Shuck, Sarah C., Cooper, Tracy, Carnahan, Robert, Szekely, Jozef, Marnett, Lawrence J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.56 MB

english, 2012

15

Cytochrome P450-Mediated Metabolism and DNA Binding of 2-Amino-1,7-dimethylimidazo[4,5- g ]quinoxaline and Its Carcinogenic Isomer 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Mice

Turesky, Robert J., Bessette, Erin E., Dunbar, Deborah, Liberman, Rosa G., Skipper, Paul L.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.62 MB

english, 2012

16

In This Issue

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 476 KB

english, 2012

17

A New LC-MS/MS Method for the Quantification of Endogenous and Vinyl Chloride-Induced 7-(2-Oxoethyl)Guanine in Sprague–Dawley Rats

Mutlu, Esra, Jeong, Yo-Chan, Collins, Leonard B., Ham, Amy-Joan L., Upton, Patricia B., Hatch, Gary, Winsett, Darrell, Evansky, Paul, Swenberg, James A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

18

Real-Time Investigation of Acute Toxicity of ZnO Nanoparticles on Human Lung Epithelia with Hopping Probe Ion Conductance Microscopy

Yang, Xi, Liu, Xiao, Lu, Hujie, Zhang, Xiaofan, Ma, Liying, Gao, Ruiling, Zhang, Yanjun

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.77 MB

english, 2012

19

Structures of (5′ S )-8,5′-Cyclo-2′-deoxyguanosine Mismatched with dA or dT

Huang, Hai, Das, Rajat S., Basu, Ashis K., Stone, Michael P.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 696 KB

english, 2012

20

Induction of Ovarian Cancer and DNA Adducts by Dibenzo[ a , l ]pyrene in the Mouse

Chen, Kun-Ming, Zhang, Shang-Min, Aliaga, Cesar, Sun, Yuan-Wan, Cooper, Timothy, Gowdahalli, Krishnegowda, Zhu, Junjia, Amin, Shantu, El-Bayoumy, Karam

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 818 KB

english, 2012

21

Oxidative DNA Damage Following Microsome/Cu(II)-Mediated Activation of the Estrogens, 17β-Estradiol, Equilenin, and Equilin: Role of Reactive Oxygen Species

Spencer, Wendy A., Vadhanam, Manicka V., Jeyabalan, Jeyaprakash, Gupta, Ramesh C.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

22

In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice

Yamazaki, Hiroshi, Suemizu, Hiroshi, Shimizu, Makiko, Igaya, Sho, Shibata, Norio, Nakamura, Masato, Chowdhury, Goutam, Guengerich, F. Peter

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 242 KB

english, 2012

23

Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ 12 -PGJ 2 through Covalent Binding to Cys 1438

Ravindra, Kodihalli C., Narayan, Vivek, Lushington, Gerald H., Peterson, Blake R., Prabhu, K. Sandeep

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.14 MB

english, 2012

24

Fast and Simultaneous Determination of Urinary 8-Hydroxy-2′-deoxyguanosine and Ten Monohydroxylated Polycyclic Aromatic Hydrocarbons by Liquid Chromatography/Tandem Mass Spectrometry

Fan, Ruifang, Wang, Dongli, Ramage, Robert, She, Jianwen

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

25

Spotlight

Rouzer, Carol A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 842 KB

english, 2012

26

Hydroxyl Radical-Induced Oxidation of a Phenolic C-Linked 2′-Deoxyguanosine Adduct Yields a Reactive Catechol

Witham, Aaron A., Beach, Daniel G., Gabryelski, Wojciech, Manderville, Richard A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

27

Quantifying Processes Determining the Free Concentration of Phenanthrene in Basal Cytotoxicity Assays

Kramer, Nynke I., Krismartina, Mirna, Rico-Rico, Ángeles, Blaauboer, Bas J., Hermens, Joop L. M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.76 MB

english, 2012

28

N 7-Glycidamide-Guanine DNA Adduct Formation by Orally Ingested Acrylamide in Rats: A Dose–Response Study Encompassing Human Diet-Related Exposure Levels

Watzek, Nico, Böhm, Nadine, Feld, Julia, Scherbl, Denise, Berger, Franz, Merz, Karl Heinz, Lampen, Alfonso, Reemtsma, Thorsten, Tannenbaum, Steven R., Skipper, Paul L., Baum, Matthias, Richling, Elke,

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.07 MB

english, 2012

29

Sequence-Dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine toward Oxidation

Lim, Kok Seong, Taghizadeh, Koli, Wishnok, John S., Babu, I. Ramesh, Shafirovich, Vladimir, Geacintov, Nicholas E., Dedon, Peter C.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 699 KB

english, 2012

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