Volume 25; Issue 3

Chemical Research in Toxicology

Volume 25; Issue 3

1

Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Mutlib, Abdul, Espina, Robert, Atherton, James, Wang, Jianyao, Talaat, Rasmy, Scatina, JoAnn, Chandrasekaran, Appavu

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 723 KB

english, 2012

2

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

Penner, Natalia, Xu, Lin, Prakash, Chandra

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.70 MB

english, 2012

3

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

Elmore, Charles S., Nilsson, Göran N., Isin, Emre M., Thompson, Richard A., Weidolf, Lars

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

4

Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.67 MB

english, 2012

5

In Vitro Evaluation of Cellular Response Induced by Manufactured Nanoparticles

Horie, Masanori, Kato, Haruhisa, Fujita, Katsuhide, Endoh, Shigehisa, Iwahashi, Hitoshi

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.82 MB

english, 2012

6

Molecular Basis of the Mechanism of Thiol Oxidation by Hydrogen Peroxide in Aqueous Solution: Challenging the SN2 Paradigm

Zeida, Ari, Babbush, Ryan, González Lebrero, Mariano C., Trujillo, Madia, Radi, Rafael, Estrin, Darío A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

7

Cyclooxygenase-2 Expression Is Up-regulated by 2-Aminobiphenyl in a ROS and MAPK-Dependent Signaling Pathway in a Bladder Cancer Cell Line

Chen, Chien-Cheng, Cheng, Yu-Yang, Chen, Ssu-Ching, Tuan, Yen-Fan, Chen, Yun-Ju, Chen, Chien-Yen, Chen, Lei-Chin

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.85 MB

english, 2012

8

Electron and Spin-Density Analysis of Tirapazamine Reduction Chemistry

Yin, Jian, Glaser, Rainer, Gates, Kent S.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.00 MB

english, 2012

9

Control of Oxidative Posttranslational Cysteine Modifications: From Intricate Chemistry to Widespread Biological and Medical Applications

Jacob, Claus, Battaglia, Eric, Burkholz, Torsten, Peng, Du, Bagrel, Denyse, Montenarh, Mathias

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 579 KB

english, 2012

10

Introduction: Use of Radioactive Compounds in Drug Discovery and Development

Guengerich, F. Peter

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 126 KB

english, 2012

11

Distinctive Toxicity of TiO 2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells

Gerloff, Kirsten, Fenoglio, Ivana, Carella, Emanuele, Kolling, Julia, Albrecht, Catrin, Boots, Agnes W., Förster, Irmgard, Schins, Roel P. F.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.78 MB

english, 2012

12

On the Reaction Mechanism of Tirapazamine Reduction Chemistry: Unimolecular N–OH Homolysis, Stepwise Dehydration, or Triazene Ring-Opening

Yin, Jian, Glaser, Rainer, Gates, Kent S.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.65 MB

english, 2012

13

Differences in Susceptibility to Inactivation of Human Aldehyde Dehydrogenases by Lipid Peroxidation Byproducts

Yoval-Sánchez, Belem, Rodríguez-Zavala, José S.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.60 MB

english, 2012

14

Correction to Effects of Smoking Cessation on Eight Urinary Tobacco Carcinogen and Toxicant Biomarkers

Carmella, Steven G., Chen, Menglan, Han, Shaomei, Briggs, Anna, Jensen, Joni, Hatsukami, Dorothy K., Hecht, Stephen S.

Journal:

Chemical Research in Toxicology

Year:

2012

File:

PDF, 102 KB

2012

15

Comparative Effects of the Marine Algal Toxins Azaspiracid-1, -2, and -3 on Jurkat T Lymphocyte Cells

Twiner, Michael J., El-Ladki, Racha, Kilcoyne, Jane, Doucette, Gregory J.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

16

Replication Bypass of N 2 -Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerases η and ι

Klug, Alex R., Harbut, Michael B., Lloyd, R. Stephen, Minko, Irina G.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.83 MB

english, 2012

17

Conjugation of Butadiene Diepoxide with Glutathione Yields DNA Adducts in Vitro and in Vivo

Cho, Sung-Hee, Guengerich, F. Peter

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 994 KB

english, 2012

18

Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-Family DNA Polymerases

Sherrer, Shanen M., Sanman, Laura E., Xia, Cynthia X., Bolin, Eric R., Malik, Chanchal K., Efthimiopoulos, Georgia, Basu, Ashis K., Suo, Zucai

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.83 MB

english, 2012

19

α-Terpinene, an Antioxidant in Tea Tree Oil, Autoxidizes Rapidly to Skin Allergens on Air Exposure

Rudbäck, Johanna, Bergström, Moa Andresen, Börje, Anna, Nilsson, Ulrika, Karlberg, Ann-Therese

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 554 KB

english, 2012

20

Effects of Polybrominated Diphenyl Ethers (PBDEs) and Their Derivatives on Protein Disulfide Isomerase Activity and Growth Hormone Release of GH3 Cells

Hashimoto, Shoko, Yoshimura, Hiromi, Okada, Kazushi, Uramaru, Naoto, Sugihara, Kazumi, Kitamura, Shigeyuki, Imaoka, Susumu

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.89 MB

english, 2012

21

In This Issue

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

22

Use of LC-MS/MS and Stable Isotopes to Differentiate Hydroxymethyl and Methyl DNA Adducts from Formaldehyde and Nitrosodimethylamine

Lu, Kun, Craft, Sessaly, Nakamura, Jun, Moeller, Benjamin C., Swenberg, James A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.02 MB

english, 2012

23

Spotlight

Rouzer, Carol A.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 283 KB

english, 2012

24

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity

Zhang, Donglu, Flint, Oliver, Wang, Lifei, Gupta, Ashok, Westhouse, Richard A., Zhao, Weiping, Raghavan, Nirmala, Caceres-Cortes, Janet, Marathe, Punit, Shen, Guoxiang, Zhang, Yueping, Allentoff, Alba

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 4.22 MB

english, 2012

25

Trans Fatty Acids: Chemical Synthesis of Eicosapentaenoic Acid Isomers and Detection in Rats Fed a Deodorized Fish Oil Diet

Ferreri, Carla, Grabovskiy, Stanislav A., Aoun, Manar, Melchiorre, Michele, Kabal’nova, Natalia, Feillet-Coudray, Christine, Fouret, Gilles, Coudray, Charles, Chatgilialoglu, Chryssostomos

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.65 MB

english, 2012

26

Metabolomic Characterization of Laborers Exposed to Welding Fumes

Kuo, Ching-Hua, Wang, Kuo-Ching, Tian, Tze-Feng, Tsai, Mong-Hsun, Chiung, Yin-Mei, Hsiech, Chun-Ming, Tsai, Sung-Jeng, Wang, San-Yuan, Tsai, Dong-Ming, Huang, Chiang-Ching, Tseng, Y. Jane

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

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