Volume 30; Issue 4

Chemical Research in Toxicology

Volume 30; Issue 4

1

Development and Validation of a Computational Model for Androgen Receptor Activity

Kleinstreuer, Nicole C., Ceger, Patricia, Watt, Eric D., Martin, Matthew, Houck, Keith, Browne, Patience, Thomas, Russell S., Casey, Warren M., Dix, David J., Allen, David, Sakamuru, Srilatha, Xia, Me

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 3.44 MB

english, 2017

2

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity

Waldmann, Tanja, Grinberg, Marianna, König, André, Rempel, Eugen, Schildknecht, Stefan, Henry, Margit, Holzer, Anna-Katharina, Dreser, Nadine, Shinde, Vaibhav, Sachinidis, Agapios, Rahnenführer, Jörg,

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 2.68 MB

english, 2017

3

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage

Hiemstra, Steven, Niemeijer, Marije, Koedoot, Esmee, Wink, Steven, Klip, Janna E., Vlasveld, Matthijs, de Zeeuw, Elisabeth, van Os, Bram, White, Andrew, Water, Bob van de

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 5.96 MB

english, 2017

4

Computational Model of Secondary Palate Fusion and Disruption

Hutson, M. Shane, Leung, Maxwell C. K., Baker, Nancy C., Spencer, Richard M., Knudsen, Thomas B.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 4.70 MB

english, 2017

5

SILAC-Based Quantitative Proteomic Analysis Unveils Arsenite-Induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells

Zhang, Fan, Xiao, Yongsheng, Wang, Yinsheng

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

6

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product

Poussin, Carine, Belcastro, Vincenzo, Martin, Florian, Boué, Stéphanie, Peitsch, Manuel C., Hoeng, Julia

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 51.50 MB

english, 2017

7

Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites, and Metabolic Pathways

Gao, Bei, Chi, Liang, Mahbub, Ridwan, Bian, Xiaoming, Tu, Pengcheng, Ru, Hongyu, Lu, Kun

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.22 MB

english, 2017

8

Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo- p -dioxin

Nault, Rance, Fader, Kelly A., Lydic, Todd A., Zacharewski, Timothy R.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 3.39 MB

english, 2017

9

Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes

Dang, Na Le, Hughes, Tyler B., Miller, Grover P., Swamidass, S. Joshua

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 3.75 MB

english, 2017

10

Evaluation of DILI Predictive Hypotheses in Early Drug Development

Chan, Rosa, Benet, Leslie Z.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.33 MB

english, 2017

11

Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX

Carmany, Dan, Walz, Andrew J., Hsu, Fu-Lian, Benton, Bernard, Burnett, David, Gibbons, Jennifer, Noort, Daan, Glaros, Trevor, Sekowski, Jennifer W.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 929 KB

english, 2017

12

Nitration of Tyrosine Residue Y10 of Aβ 1–42 Significantly Inhibits Its Aggregation and Cytotoxicity

Zhao, Jie, Wu, Jinming, Yang, Zhen, Li, Hailing, Gao, Zhonghong

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

13

Silver Nanoparticles and Metallic Silver Interfere with the Griess Reaction: Reduction of Azo Dye Formation via a Competing Sandmeyer-Like Reaction

Kämpfer, Angela, La Spina, Rita, Gilliland, Douglas, Valzacchi, Sandro, Asturiol, David, Stone, Vicki, Kinsner-Ovaskainen, Agnieszka

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 995 KB

english, 2017

14

Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells

Ming, Xun, Groehler, Arnold, Michaelson-Richie, Erin D., Villalta, Peter W., Campbell, Colin, Tretyakova, Natalia Y.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

15

Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells

Huang, Meng, Mesaros, Clementina, Hackfeld, Linda C., Hodge, Richard P., Zang, Tianzhu, Blair, Ian A., Penning, Trevor M.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

16

Variation in Free Radical Yields from U.S. Marketed Cigarettes

Goel, Reema, Bitzer, Zachary, Reilly, Samantha M., Trushin, Neil, Foulds, Jonathan, Muscat, Joshua, Liao, Jason, Elias, Ryan J., Richie, John P.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 673 KB

english, 2017

17

Oncometabolites d - and l -2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions

Chen, Fangyi, Bian, Ke, Tang, Qi, Fedeles, Bogdan I., Singh, Vipender, Humulock, Zachary T., Essigmann, John M., Li, Deyu

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 2.01 MB

english, 2017

18

Systems Toxicology: Real World Applications and Opportunities

Hartung, Thomas, FitzGerald, Rex E., Jennings, Paul, Mirams, Gary R., Peitsch, Manuel C., Rostami-Hodjegan, Amin, Shah, Imran, Wilks, Martin F., Sturla, Shana J.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.01 MB

english, 2017

19

Systems Toxicology II: A Special Issue

Hartung, Thomas, Kavlock, Robert, Sturla, Shana J.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 186 KB

english, 2017

20

Spotlight

Druck Shudofsky, Abigail

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 379 KB

english, 2017

21

Issue Editorial Masthead

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 159 KB

english, 2017

22

Issue Publication Information

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 157 KB

english, 2017