Volume 6; Issue 11

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Chemistry & Biodiversity
Volume 6; Issue 11

Chemistry & Biodiversity

Volume 6; Issue 11

1

Drug Metabolism for the Perplexed Medicinal Chemist

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 713 KB

english, 2009

2

Impact of Acute Streptozotocin-Induced Diabetes on ABC Transporter Expression in Rats

Gregory J. Anger, Lilia Magomedova, Micheline Piquette-Miller

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 392 KB

english, 2009

3

Measurement and Prediction of Oral Absorption

Joerg Keldenich

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 609 KB

english, 2009

4

Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

Amit S. Kalgutkar, Mary T. Didiuk

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 308 KB

english, 2009

5

Improving Compound Quality through in vitro and in silico Physicochemical Profiling

Han van de Waterbeemd

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 118 KB

english, 2009

6

Stability Challenges in Drug Discovery

Li Di, Edward H. Kerns

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 316 KB

english, 2009

7

Membrane Permeability in the Gastrointestinal Tract: The Interplay between Microclimate pH and Transporters

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

8

Probabilistic Prediction of the Human CYP3A4 and CYP2D6 Metabolism Sites

Justas Dapkunas, Andrius Sazonovas, Pranas Japertas

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 136 KB

english, 2009

9

Ionization-Specific QSAR Models of Blood–Brain Penetration of Drugs

Kiril Lanevskij, Pranas Japertas, Remigijus Didziapetris, Alanas Petrauskas

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 174 KB

english, 2009

10

Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Alex Avdeef, Konstantin Tsinman, Oksana Tsinman, Na Sun, Dmytro Voloboy

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 389 KB

english, 2009

11

Computational Oral Absorption Simulation for Low-Solubility Compounds

Kiyohiko Sugano

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 509 KB

english, 2009

12

Potentiation of MRP2/Mrp2-Mediated Estradiol-17β-Glucuronide Transport by Drugs – A Concise Review

Krisztina Herédi-Szabó, Katalin Jemnitz, Emese Kis, Enikő Ioja, Judit Jánossy, László Vereczkey, Peter Krajcsi

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 161 KB

english, 2009

13

Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept

Andreas Reichel

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 1.46 MB

english, 2009

14

In silico Prediction of Human Oral Absorption Based on QSAR Analyses of PAMPA Permeability

Miki Akamatsu, Masaaki Fujikawa, Kazuya Nakao, Ryo Shimizu

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 382 KB

english, 2009

15

Small Chemicals, Bioactivation, and the Immune System – A Fragile Balance of i-Tox and Benefits?

Charlotte Esser, Bettina Jux

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 201 KB

english, 2009

16

Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility

Christa E. Müller

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 895 KB

english, 2009

17

Lipophilicity Determination of Highly Lipophilic Compounds by Liquid Chromatography

Amandine Guillot, Yveline Henchoz, Cyril Moccand, Davy Guillarme, Jean-Luc Veuthey, Pierre-Alain Carrupt, Sophie Martel

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 176 KB

english, 2009

18

Prediction of Pharmacokinetic Profile of Valsartan in Humans Based on in vitro Uptake-Transport Data

Agnès Poirier, Anne-Christine Cascais, Christoph Funk, Thierry Lavé

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 306 KB

english, 2009

19

Recent Advances in Physicochemical and ADMET Profiling in Drug Discovery

Jianling Wang, Suzanne Skolnik

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 353 KB

english, 2009

20

A Fast Method for pKa Determination by Capillary Electrophoresis

Elisabet Fuguet, Clara Ràfols, Elisabeth Bosch, Martí Rosés

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 174 KB

english, 2009

21

Kinetic and Thermodynamic Solubility Values of Some Bioactive Compounds

Elham Shoghi, Elisabet Fuguet, Clara Ràfols, Elisabeth Bosch

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 176 KB

english, 2009

22

Lipid-Bilayer Permeation of Drug-Like Compounds

Stefanie D. Krämer, Dario Lombardi, Adriana Primorac, Anita V. Thomae, Heidi Wunderli-Allenspach

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 526 KB

english, 2009

23

The Unstirrable Water Layer Is Unstirrable because It Does Not Exist

Robert A. Scherrer

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

24

An Expert System Approach to the Assessment of Hepatotoxic Potential

Carol A. Marchant, Lilia Fisk, Reine R. Note, Mukesh L. Patel, Diana Suárez

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 125 KB

english, 2009

25

RNA-Interference Approach to Study Functions of NADPH : Cytochrome P450 Oxidoreductase in Human Hepatocytes

Diana M. Feidt, Kathrin Klein, Andreas Nüssler, Ulrich M. Zanger

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 614 KB

english, 2009

26

Predicting Ligand Interactions with ABC Transporters in ADME

Michael A. Demel, O. Krämer, Peter Ettmayer, Eric E. J. Haaksma, Gerhard F. Ecker

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 747 KB

english, 2009

27

Beyond Profiling: Using ADMET Models to Guide Decisions

Matthew Segall, Edmund Champness, Olga Obrezanova, Chris Leeding

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 643 KB

english, 2009

28

A PAMPA Study of the Permeability-Enhancing Effect of New Ceramide Analogues

Bálint Sinkó, József Kökösi, Alex Avdeef, Krisztina Takács-Novák

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 190 KB

english, 2009

29

Transporters – The View from Industry

Christopher Kohl

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 607 KB

english, 2009

30

In silico pKa Prediction and ADME Profiling

Gabriele Cruciani, Francesca Milletti, Loriano Storchi, Gianluca Sforna, Laura Goracci

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 495 KB

english, 2009

31

New Ideas about the Solubility of Drugs

Karl Box, John E. Comer, Tom Gravestock, Martin Stuart

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 582 KB

english, 2009

32

Editorial

Stefanie Krämer, Bernard Testa

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 48 KB

english, 2009

33

Transporters in Absorption, Distribution, and Elimination

Jean-Michel Scherrmann

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 574 KB

english, 2009

34

Influence of Ionization State on the Activation of Temocapril by hCES1: A Molecular-Dynamics Study

Giulio Vistoli, Alessandro Pedretti, Angelica Mazzolari, Cristiano Bolchi, Bernard Testa

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 468 KB

english, 2009

35

Contents: C&B 11/2009

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 1.31 MB

english, 2009

36

Large-Scale Evaluation of log P Predictors: Local Corrections May Compensate Insufficient Accuracy and Need of Experimentally Testing Every Other Compound

Igor V. Tetko, Gennadiy I. Poda, Claude Ostermann, Raimund Mannhold

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 307 KB

english, 2009

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