Volume 11; Issue 10

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Chemistry & Biology
Volume 11; Issue 10

Chemistry & Biology

Volume 11; Issue 10

1

Disruption of Protein-Membrane Binding and Identification of Small-Molecule Inhibitors of Coagulation Factor VIII

P.Clint Spiegel, Shari M. Kaiser, Julian A. Simon, Barry L. Stoddard

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 372 KB

english, 2004

2

A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins

Zarixia Zavala-Ruiz, Iwona Strug, Matthew W. Anderson, Jack Gorski, Lawrence J. Stern

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 339 KB

english, 2004

3

The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin: The Sulfur Transfer Mediated by the Sulfur Carrier Protein ThiS

Pieter C. Dorrestein, Huili Zhai, Fred W. McLafferty, Tadhg P. Begley

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

4

Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts

Christopher D. Reeves, Shannon L. Ward, W.Peter Revill, Hideki Suzuki, Matthew Marcus, Oleg V. Petrakovsky, Saul Marquez, Hong Fu, Steven D. Dong, Leonard Katz

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

5

Molecular Dynamics Simulation Links Conformation of a Pore-Flanking Region to Hyperekplexia-Related Dysfunction of the Inhibitory Glycine Receptor

Hans-Georg Breitinger, Harald Lanig, Christine Vohwinkel, Christof Grewer, Ulrike Breitinger, Tim Clark, Cord-Michael Becker

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 404 KB

english, 2004

6

PNA-Encoded Protease Substrate Microarrays

Nicolas Winssinger, Robert Damoiseaux, David C. Tully, Bernhard H. Geierstanger, Keith Burdick, Jennifer L. Harris

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 559 KB

english, 2004

7

Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays

Jennifer Harris, Daniel E. Mason, Jun Li, Keith W. Burdick, Bradley J. Backes, Teresa Chen, Aaron Shipway, Gino Van Heeke, Lucy Gough, Amir Ghaemmaghami, Farouk Shakib, François Debaene, Nicolas Winss

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 690 KB

english, 2004

8

Combating Susceptibility to Drug Resistance: Lessons from HIV-1 Protease

Nancy M. King, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Celia A. Schiffer

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 330 KB

english, 2004

9

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase

Jan E. Blanchard, Nadine H. Elowe, Carly Huitema, Pascal D. Fortin, Jonathan D. Cechetto, Lindsay D. Eltis, Eric D. Brown

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 258 KB

english, 2004

10

Crystal Structure and Mechanistic Implications of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase—The Ethylene-Forming Enzyme

Zhihong Zhang, Jing-Shang Ren, Ian J. Clifton, Christopher J. Schofield

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 1.21 MB

english, 2004

11

Wide-Angle X-Ray Solution Scattering as a Probe of Ligand-Induced Conformational Changes in Proteins

R.F. Fischetti, D.J. Rodi, D.B. Gore, L. Makowski

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 769 KB

english, 2004

12

Multicopy Suppressors for Novel Antibacterial Compounds Reveal Targets and Drug Efflux Susceptibility

Xiaoming Li, Michela Zolli-Juran, Jonathan D. Cechetto, Denis M. Daigle, Gerard D. Wright, Eric D. Brown

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 229 KB

english, 2004

13

A New Curcumin Derivative, HBC, Interferes with the Cell Cycle Progression of Colon Cancer Cells via Antagonization of the Ca2+/Calmodulin Function

Joong Sup Shim, Jiyong Lee, Hyun-Ju Park, So-Jung Park, Ho Jeong Kwon

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 1.72 MB

english, 2004

14

Novel Avilamycin Derivatives with Improved Polarity Generated by Targeted Gene Disruption

Gabriele Weitnauer, Gerd Hauser, Carsten Hofmann, Ulrike Linder, Raija Boll, Klaus Pelz, Steffen J. Glaser, Andreas Bechthold

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 197 KB

english, 2004

15

Catching Proteases in Action with Microarrays

Howard C. Hang, Hidde Ploegh

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 93 KB

english, 2004

16

An `Inside-the-Box' Approach to Drug Resistance

Kent D. Stewart, Dale J. Kempf

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 36 KB

english, 2004

17

A Suppression Strategy for Antibiotic Discovery

Helena Gaweska, Joseph Kielec, Dewey McCafferty

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 83 KB

english, 2004

18

The Genetics of Autism

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 31 KB

english, 2004

19

The Biosynthesis of the Thiazole Phosphate Moiety of ThiaminThe Sulfur Transfer Mediated by the Sulfur Carrier Protein ThiS

DORRESTEIN, P, ZHAI, H, MCLAFFERTY, F, BEGLEY, T

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

20

Combating Susceptibility to Drug ResistanceLessons from HIV-1 Protease

KING, N, PRABUJEYABALAN, M, NALIVAIKA, E, SCHIFFER, C

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 330 KB

english, 2004

21

The Genetics of Autism

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 31 KB

english, 2004