Volume 21; Issue 5

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Chemistry & Biology
Volume 21; Issue 5

Chemistry & Biology

Volume 21; Issue 5

1

Sulindac-Derived RXRα Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site

Chen, Liqun, Wang, Zhi-Gang, Aleshin, Alexander E., Chen, Fan, Chen, Jiebo, Jiang, Fuquan, Alitongbieke, Gulimiran, Zeng, Zhiping, Ma, Yue, Huang, Mingfeng, Zhou, Hu, Cadwell, Gregory, Zheng, Jian-Fen

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.45 MB

english, 2014

2

Privileged Diazepine Compounds and Their Emergence as Bromodomain Inhibitors

Smith, Steven G., Sanchez, Roberto, Zhou, Ming-Ming

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

3

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

Scott, John W., Ling, Naomi, Issa, Samah M.A., Dite, Toby A., O’Brien, Matthew T., Chen, Zhi-Ping, Galic, Sandra, Langendorf, Christopher G., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

4

Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase

Ye, Zhixia, Musiol, Ewa M., Weber, Tilmann, Williams, Gavin J.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.62 MB

english, 2014

5

Genome Mining Reveals a Minimum Gene Set for the Biosynthesis of 32-Membered Macrocyclic Thiopeptides Lactazoles

Hayashi, Shohei, Ozaki, Taro, Asamizu, Shumpei, Ikeda, Haruo, Ōmura, Satoshi, Oku, Naoya, Igarashi, Yasuhiro, Tomoda, Hiroshi, Onaka, Hiroyasu

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

6

Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

Guo, Junhong, Huang, Fanglu, Huang, Chuan, Duan, Xiaobo, Jian, Xinyun, Leeper, Finian, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014

7

A Crosslinker Based on a Tethered Electrophile for Mapping Kinase-Substrate Networks

Riel-Mehan, Megan M., Shokat, Kevan M.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1022 KB

english, 2014

8

Synthetic Interaction between the TipN Polarity Factor and an AcrAB-Family Efflux Pump Implicates Cell Polarity in Bacterial Drug Resistance

Kirkpatrick, Clare L., Viollier, Patrick H.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.82 MB

english, 2014

9

Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases

Hari, Sanjay B., Merritt, Ethan A., Maly, Dustin J.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

10

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

Warner, Katherine Deigan, Homan, Philip, Weeks, Kevin M., Smith, Alison G., Abell, Chris, Ferré-D’Amaré, Adrian R.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 741 KB

english, 2014

11

Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery

Wang, Huanchen, Godage, Himali Y., Riley, Andrew M., Weaver, Jeremy D., Shears, Stephen B., Potter, Barry V.L.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

12

VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR after Its Partial Rescue to the Cell Surface

Eckford, Paul D.W., Ramjeesingh, Mohabir, Molinski, Steven, Pasyk, Stan, Dekkers, Johanna F., Li, Canhui, Ahmadi, Saumel, Ip, Wan, Chung, Timothy E., Du, Kai, Yeger, Herman, Beekman, Jeffrey, Gonska,

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.64 MB

english, 2014

13

Regulation of the ROS Response Dynamics and Organization to PDGF Motile Stimuli Revealed by Single Nanoparticle Imaging

Bouzigues, Cedric I., Nguyên, Thanh-Liêm, Ramodiharilafy, Rivo, Claeson, Amy, Tharaux, Pierre-Louis, Alexandrou, Antigoni

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

14

In This Issue

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 644 KB

english, 2014

15

Modulating Noncatalytic Function with Kinase Inhibitors

Agius, Michael P., Soellner, Matthew B.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 451 KB

english, 2014

16

Antigenic Peptides, Brain Imaging by CUBIC, and Mitochondrial Lipid Mediator Production

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 266 KB

english, 2014

17

Bypassing AMPK Phosphorylation

Viollet, Benoit, Foretz, Marc, Schlattner, Uwe

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 488 KB

english, 2014

18

Polarity Factors Play a Role in Antibiotic Resistance

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 228 KB

english, 2014