Volume 10; Issue 4

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ChemMedChem
Volume 10; Issue 4

ChemMedChem

Volume 10; Issue 4

1

Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules

Pagano, Bruno, Amato, Jussara, Iaccarino, Nunzia, Cingolani, Chiara, Zizza, Pasquale, Biroccio, Annamaria, Novellino, Ettore, Randazzo, Antonio

Journal:

Year:

2015

Language:

english

File:

PDF, 3.01 MB

english, 2015

2

Selective Inhibitors of Glutathione Transferase P1 with Trioxane Structure as Anticancer Agents

Bräutigam, Maria, Teusch, Nicole, Schenk, Tobias, Sheikh, Miriam, Aricioglu, Rocky Z., Borowski, Swantje H., Neudörfl, Jörg-Martin, Baumann, Ulrich, Griesbeck, Axel G., Pietsch, Markus

Journal:

Year:

2015

Language:

english

File:

PDF, 577 KB

english, 2015

3

In Vivo Targeting through Click Chemistry

Brudno, Yevgeny, Desai, Rajiv M., Kwee, Brian J., Joshi, Neel S., Aizenberg, Michael, Mooney, David J.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.97 MB

english, 2015

4

Pharmacophore-Based Design of Novel Oxadiazoles as Selective Sphingosine-1-phosphate (S1P) Receptor Agonists with in vivo Efficacy

Quattropani, Anna, Sauer, Wolfgang H. B., Crosignani, Stefano, Dorbais, Jerome, Gerber, Patrick, Gonzalez, Jerome, Marin, Delphine, Muzerelle, Mathilde, Beltran, Fanny, Nichols, Anthony, Georgi, Katri

Journal:

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

5

Design and Synthesis of a MAO-B-Selectively Activated Prodrug Based on MPTP: A Mitochondria-Targeting Chemotherapeutic Agent for Treatment of Human Malignant Gliomas

Sharpe, Martyn A., Han, Junyan, Baskin, Alexandra M., Baskin, David S.

Journal:

Year:

2015

Language:

english

File:

PDF, 1019 KB

english, 2015

6

Corrigendum: Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists

Zhu, Junjie, Ye, Yangliang, Ning, Mengmeng, Mándi, Attila, Feng, Ying, Zou, Qingan, Kurtán, Tibor, Leng, Ying, Shen, Jianhua

Journal:

Year:

2015

File:

PDF, 102 KB

2015

7

Fluorine in Drug Design: A Case Study with Fluoroanisoles

Xing, Li, Blakemore, David C., Narayanan, Arjun, Unwalla, Ray, Lovering, Frank, Denny, R. Aldrin, Zhou, Huanyu, Bunnage, Mark E.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.74 MB

english, 2015

8

Bioisosteric Matrices for Ligands of Serotonin Receptors

Warszycki, Dawid, Mordalski, Stefan, Staroń, Jakub, Bojarski, Andrzej J.

Journal:

Year:

2015

Language:

english

File:

PDF, 636 KB

english, 2015

9

Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases

Dudutienė, Virginija, Zubrienė, Asta, Smirnov, Alexey, Timm, David D., Smirnovienė, Joana, Kazokaitė, Justina, Michailovienė, Vilma, Zakšauskas, Audrius, Manakova, Elena, Gražulis, Saulius, Matulis, D

Journal:

Year:

2015

Language:

english

File:

PDF, 3.17 MB

english, 2015

10

Cover Picture: Design and Synthesis of a MAO-B-Selectively Activated Prodrug Based on MPTP: A Mitochondria-Targeting Chemotherapeutic Agent for Treatment of Human Malignant Gliomas (ChemMedChem 4/2015)

Sharpe, Martyn A., Han, Junyan, Baskin, Alexandra M., Baskin, David S.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

11

Scaffold Identification of a New Class of Potent and Selective BCRP Inhibitors

Marighetti, Federico, Steggemann, Kerstin, Karbaum, Maria, Wiese, Michael

Journal:

Year:

2015

Language:

english

File:

PDF, 817 KB

english, 2015

12

P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325

Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara

Journal:

Year:

2015

Language:

english

File:

PDF, 791 KB

english, 2015

13

Synthesis and In Vitro Antiproliferative Activity of Amido and Amino Analogues of the Marine Alkaloid Isogranulatimide

Lavrard, Hubert, Salvetti, Béatrice, Mathieu, Véronique, Rodriguez, Frédéric, Kiss, Robert, Delfourne, Evelyne

Journal:

Year:

2015

Language:

english

File:

PDF, 301 KB

english, 2015

14

Suppression of Problematic Compound Oligomerization by Cosolubilization of Nondetergent Sulfobetaines

Mizukoshi, Yumiko, Takeuchi, Koh, Arutaki, Misa, Takizawa, Takeshi, Hanzawa, Hiroyuki, Takahashi, Hideo, Shimada, Ichio

Journal:

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

15

The Predicted Ensemble of Low-Energy Conformations of Human Somatostatin Receptor Subtype 5 and the Binding of Antagonists

Dong, Sijia S., Abrol, Ravinder, Goddard, William A.

Journal:

Year:

2015

Language:

english

File:

PDF, 14.85 MB

english, 2015

16

Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV-2 Microglia

Wu, Jing, Du, Juanjuan, Gu, Ruinan, Zhang, Li, Zhen, Xuechu, Li, Yuanchao, Chen, Hongli, Jiang, Biao, Zheng, Longtai

Journal:

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

17

Spotlights on our sister journals: ChemMedChem 4/2015

Journal:

Year:

2015

Language:

english

File:

PDF, 6.03 MB

english, 2015

18

Graphical Abstract: ChemMedChem 4/2015

Journal:

Year:

2015

Language:

english

File:

PDF, 6.26 MB

english, 2015

19

Inside Cover: Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules (ChemMedChem 4/2015)

Pagano, Bruno, Amato, Jussara, Iaccarino, Nunzia, Cingolani, Chiara, Zizza, Pasquale, Biroccio, Annamaria, Novellino, Ettore, Randazzo, Antonio

Journal:

Year:

2015

File:

PDF, 6.74 MB

2015

20

Back Cover: Selective Inhibitors of Glutathione Transferase P1 with Trioxane Structure as Anticancer Agents (ChemMedChem 4/2015)

Bräutigam, Maria, Teusch, Nicole, Schenk, Tobias, Sheikh, Miriam, Aricioglu, Rocky Z., Borowski, Swantje H., Neudörfl, Jörg-Martin, Baumann, Ulrich, Griesbeck, Axel G., Pietsch, Markus

Journal:

Year:

2015

File:

PDF, 2.73 MB

2015

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