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Volume 11; Issue 8
Main
ChemMedChem
Volume 11; Issue 8
ChemMedChem
Volume 11; Issue 8
1
Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates
Drennen, Brandon
,
Scheenstra, Jacob A.
,
Yap, Jeremy L.
,
Chen, Lijia
,
Lanning, Maryanna E.
,
Roth, Braden M.
,
Wilder, Paul T.
,
Fletcher, Steven
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.71 MB
Your tags:
english, 2016
2
STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy
Yeh, Jennifer E.
,
Frank, David A.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 495 KB
Your tags:
english, 2016
3
Virtual Screening and Experimental Validation Identify Novel Inhibitors of the Plasmodium falciparum Atg8-Atg3 Protein-Protein Interaction
Hain, Adelaide U. P.
,
Miller, Alexia S.
,
Levitskaya, Jelena
,
Bosch, Jürgen
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 3.60 MB
Your tags:
english, 2016
4
Hitting a Moving Target: How Does an N -Methyl Group Impact Biological Activity?
Koay, Yen Chin
,
Richardson, Nicole L.
,
Zaiter, Samantha S.
,
Kho, Jessica
,
Nguyen, Sheena Y.
,
Tran, Daniel H.
,
Lee, Ka Wai
,
Buckton, Laura K.
,
McAlpine, Shelli R.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.63 MB
Your tags:
english, 2016
5
Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors
Ohashi, Nami
,
Harada, Shigeyoshi
,
Mizuguchi, Takaaki
,
Irahara, Yu
,
Yamada, Yuko
,
Kotani, Misato
,
Nomura, Wataru
,
Matsushita, Shuzo
,
Yoshimura, Kazuhisa
,
Tamamura, Hirokazu
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.09 MB
Your tags:
english, 2016
6
Spotlights on our sister journals: ChemMedChem 8/2016
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.40 MB
Your tags:
english, 2016
7
Effect of N-Terminal Acylation on the Activity of Myostatin Inhibitory Peptides
Takayama, Kentaro
,
Nakamura, Akari
,
Rentier, Cédric
,
Mino, Yusaku
,
Asari, Tomo
,
Saga, Yusuke
,
Taguchi, Akihiro
,
Yakushiji, Fumika
,
Hayashi, Yoshio
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 673 KB
Your tags:
english, 2016
8
Inhibitors of Ras-SOS Interactions
Lu, Shaoyong
,
Jang, Hyunbum
,
Zhang, Jian
,
Nussinov, Ruth
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.85 MB
Your tags:
english, 2016
9
How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures
Estrada-Ortiz, Natalia
,
Neochoritis, Constantinos G.
,
Dömling, Alexander
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 6.67 MB
Your tags:
english, 2016
10
Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease
Gable, Jonathan E.
,
Lee, Gregory M.
,
Acker, Timothy M.
,
Hulce, Kaitlin R.
,
Gonzalez, Eric R.
,
Schweigler, Patrick
,
Melkko, Samu
,
Farady, Christopher J.
,
Craik, Charles S.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.37 MB
Your tags:
english, 2016
11
Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling
Bertoldo, Davide
,
Khan, Maola M. G.
,
Dessen, Pierre
,
Held, Werner
,
Huelsken, Joerg
,
Heinis, Christian
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.88 MB
Your tags:
english, 2016
12
Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities
Ali, Ahmed M.
,
Gómez-Biagi, Rodolfo F.
,
Rosa, David A.
,
Lai, Ping-Shan
,
Heaton, William L.
,
Park, Ji Sung
,
Eiring, Anna M.
,
Vellore, Nadeem A.
,
de Araujo, Elvin D.
,
Ball, Dan P.
,
Shouksmith, Andrew E.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.40 MB
Your tags:
english, 2016
13
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH
Bottini, Angel
,
Wu, Bainan
,
Barile, Elisa
,
De, Surya K.
,
Leone, Marilisa
,
Pellecchia, Maurizio
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 3.31 MB
Your tags:
english, 2016
14
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A
Patrone, James D.
,
Pelz, Nicholas F.
,
Bates, Brittney S.
,
Souza-Fagundes, Elaine M.
,
Vangamudi, Bhavatarini
,
Camper, Demarco V.
,
Kuznetsov, Alexey G.
,
Browning, Carrie F.
,
Feldkamp, Michael D.
,
Frank,
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.04 MB
Your tags:
english, 2016
15
Structure-Activity Studies of Bis- O -Arylglycolamides: Inhibitors of the Integrated Stress Response
Hearn, Brian R.
,
Jaishankar, Priyadarshini
,
Sidrauski, Carmela
,
Tsai, Jordan C.
,
Vedantham, Punitha
,
Fontaine, Shaun D.
,
Walter, Peter
,
Renslo, Adam R.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 726 KB
Your tags:
english, 2016
16
Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface
Bier, David
,
Bartel, Maria
,
Sies, Katharina
,
Halbach, Sebastian
,
Higuchi, Yusuke
,
Haranosono, Yu
,
Brummer, Tilman
,
Kato, Nobuo
,
Ottmann, Christian
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 3.70 MB
Your tags:
english, 2016
17
Current Experimental Methods for Characterizing Protein-Protein Interactions
Zhou, Mi
,
Li, Qing
,
Wang, Renxiao
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.78 MB
Your tags:
english, 2016
18
Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors
Yan, Lei
,
Liang, Jiaqi
,
Yao, Chengbo
,
Wu, Peiyao
,
Zeng, Xianfeng
,
Cheng, Kui
,
Yin, Hang
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.85 MB
Your tags:
english, 2016
19
Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions
Cardote, Teresa A. F.
,
Ciulli, Alessio
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.13 MB
Your tags:
english, 2016
20
Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor
Bayó-Puxan, Núria
,
Rodríguez-Mias, Ricard
,
Goldflam, Michael
,
Kotev, Martin
,
Ciudad, Sonia
,
Hipolito, Christopher J.
,
Varese, Monica
,
Suga, Hiroaki
,
Campos-Olivas, Ramón
,
Barril, Xavier
,
Guallar, Víct
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.46 MB
Your tags:
english, 2016
21
Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1
Beekman, Andrew M.
,
Howell, Lesley A.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 1.37 MB
Your tags:
english, 2016
22
Targeting Protein-Protein Interactions in the HIF System
Wilkins, Sarah E.
,
Abboud, Martine I.
,
Hancock, Rebecca L.
,
Schofield, Christopher J.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 2.61 MB
Your tags:
english, 2016
23
Cover Picture: Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors (ChemMedChem 8/2016)
Yan, Lei
,
Liang, Jiaqi
,
Yao, Chengbo
,
Wu, Peiyao
,
Zeng, Xianfeng
,
Cheng, Kui
,
Yin, Hang
Journal:
ChemMedChem
Year:
2016
File:
PDF, 313 KB
Your tags:
2016
24
Inside Cover: Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities (ChemMedChem 8/2016)
Ali, Ahmed M.
,
Gómez-Biagi, Rodolfo F.
,
Rosa, David A.
,
Lai, Ping-Shan
,
Heaton, William L.
,
Park, Ji Sung
,
Eiring, Anna M.
,
Vellore, Nadeem A.
,
de Araujo, Elvin D.
,
Ball, Dan P.
,
Shouksmith, Andrew E.
Journal:
ChemMedChem
Year:
2016
File:
PDF, 1.06 MB
Your tags:
2016
25
Back Cover: High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (ChemMedChem 8/2016)
Bottini, Angel
,
Wu, Bainan
,
Barile, Elisa
,
De, Surya K.
,
Leone, Marilisa
,
Pellecchia, Maurizio
Journal:
ChemMedChem
Year:
2016
File:
PDF, 818 KB
Your tags:
2016
26
Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1)
Beekman, Andrew M.
,
O'Connell, Maria A.
,
Howell, Lesley A.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 3.39 MB
Your tags:
english, 2016
27
Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 2)
Wilson, Andrew J.
,
Gunning, Patrick T.
Journal:
ChemMedChem
Year:
2016
Language:
english
File:
PDF, 417 KB
Your tags:
english, 2016
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