Volume 3; Issue 1

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ChemMedChem
Volume 3; Issue 1

ChemMedChem

Volume 3; Issue 1

1

Prodrug Strategies in Anticancer Chemotherapy

Felix Kratz, Ivonne A. Müller, Claudia Ryppa, André Warnecke

Journal:

Year:

2008

Language:

english

File:

PDF, 2.25 MB

english, 2008

2

2′-O-Lysylaminohexyl Oligonucleotides: Modifications for Antisense and siRNA

Johannes Winkler, Matthias Gilbert, Aneta Kocourková, Martina Stessl, Christian R. Noe

Journal:

Year:

2008

Language:

english

File:

PDF, 393 KB

english, 2008

3

CMP-Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway in Campylobacter jejuni and Helicobacter pylori

David J. McNally, Ian C. Schoenhofen, R. Scott Houliston, Nam H. Khieu, Dennis M. Whitfield, Susan M. Logan, Harold C. Jarrell, Jean-Robert Brisson

Journal:

Year:

2008

Language:

english

File:

PDF, 295 KB

english, 2008

4

Selective Human Adenosine A3 Antagonists based on Pyrido[2,1-f]purine-2,4-diones: Novel Features of hA3 Antagonist Binding

Eva-María Priego, María-Jesús Pérez-Pérez, Jacobien K. von Frijtag Drabbe Kuenzel, Henk de Vries, Adriaan P. IJzerman, María-José Camarasa, Sonsoles Martín-Santamaría

Journal:

Year:

2008

Language:

english

File:

PDF, 479 KB

english, 2008

5

Probing Novel 1-Aza-9-oxafluorenes as Selective GSK-3β Inhibitors

Burkhardt Voigt, Martin Krug, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth

Journal:

Year:

2008

Language:

english

File:

PDF, 287 KB

english, 2008

6

Synthesis and Anticancer Activity of (R,S)-9-(2,3-Dihydro-1,4-Benzoxathiin-3-ylmethyl)-9H-Purines

Mónica Díaz-Gavilán, Ana Conejo-García, Olga Cruz-López, María C. Núñez, Duane Choquesillo-Lazarte, Josefa M. González-Pérez, Fernando Rodríguez-Serrano, Juan A. Marchal, Antonia Aránega, Miguel A. Ga

Journal:

Year:

2008

Language:

english

File:

PDF, 367 KB

english, 2008

7

A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

Eliana Gianolio, Giovanni Battista Giovenzana, Anna Ciampa, Stefania Lanzardo, Daniela Imperio, Silvio Aime

Journal:

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

8

Thioflavin Derivatives as Markers for Amyloid-β Fibrils: Insights into Structural Features Important for High-Affinity Binding

Rodrigue Leuma Yona, Serge Mazères, Peter Faller, Emmanuel Gras

Journal:

Year:

2008

Language:

english

File:

PDF, 191 KB

english, 2008

9

Fragmental Modeling of Human Glutamate Transporter EAAT1 and Analysis of its Binding Modes by Docking and Pharmacophore Mapping

Alessandro Pedretti, Laura De Luca, Cristina Sciarrillo, Giulio Vistoli

Journal:

Year:

2008

Language:

english

File:

PDF, 887 KB

english, 2008

10

Similarity Searching using Compound Class-Specific Combinations of Substructures Found in Randomly Generated Molecular Fragment Populations

José Batista, Jürgen Bajorath

Journal:

Year:

2008

Language:

english

File:

PDF, 292 KB

english, 2008

11

Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

Simona M. Ceccarelli, Götz Schlotterbeck, Patrick Boissin, Martin Binder, Bernd Buettelmann, Steven Hanlon, Georg Jaeschke, Sabine Kolczewski, Ernst Kupfer, Jens-Uwe Peters, Richard H. P. Porter, Eric

Journal:

Year:

2008

Language:

english

File:

PDF, 448 KB

english, 2008

12

Synthesis and Activity of a Trinuclear Platinum Complex: [{trans-PtCl(NH3)2}2μ-{trans-Pt(3-hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in Ovarian Cancer Cell Lines

Hasan Tayyem, Fazlul Huq, Jun Qing Yu, Philip Beale, Keith Fisher

Journal:

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

13

Sila-Haloperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate

Reinhold Tacke, Friedrich Popp, Barbara Müller, Bastian Theis, Christian Burschka, Alexandra Hamacher, Matthias U. Kassack, Dirk Schepmann, Bernhard Wünsch, Ulrik Jurva, Eric Wellner

Journal:

Year:

2008

Language:

english

File:

PDF, 418 KB

english, 2008

14

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis

Christine M. Crane, Anna K. H. Hirsch, Magnus S. Alphey, Tanja Sgraja, Susan Lauw, Victoria Illarionova, Felix Rohdich, Wolfgang Eisenreich, William N. Hunter, Adelbert Bacher, François Diederich

Journal:

Year:

2008

Language:

english

File:

PDF, 635 KB

english, 2008

15

Design, Synthesis, and Biological Evaluation of Caprolactam-Modified Bengamide Analogues

Gang Liu, Yi-Ming Ma, Wan-Yi Tai, Chuan-Ming Xie, Yu-Lin Li, Jia Li, Fa-Jun Nan

Journal:

Year:

2008

Language:

english

File:

PDF, 222 KB

english, 2008

16

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

Rajeshwar Narlawar, Marcus Pickhardt, Stefanie Leuchtenberger, Karlheinz Baumann, Sabine Krause, Thomas Dyrks, Sascha Weggen, Eckhard Mandelkow, Boris Schmidt

Journal:

Year:

2008

Language:

english

File:

PDF, 324 KB

english, 2008

17

Hyrtiosal, from the Marine Sponge Hyrtios erectus, Inhibits HIV-1 Integrase Binding to Viral DNA by a New Inhibitor Binding Site

Li Du, Liangliang Shen, Zhiguo Yu, Jing Chen, Yuewei Guo, Yun Tang, Xu Shen, Hualiang Jiang

Journal:

Year:

2008

Language:

english

File:

PDF, 500 KB

english, 2008

18

Foldamers: Structure, Properties, and Applications. Edited by Stefan Hecht and Ivan Huc.

Journal:

Year:

2008

Language:

english

File:

PDF, 97 KB

english, 2008

19

Highlighting the New Advances in Drug Discovery and Development

Sabrina Taliani, Federico Da Settimo

Journal:

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

20

Increasing Attention

Brid NicNiocaill, Scott D. Williams, Peter Gölitz

Journal:

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

21

Structural Genomics on Membrane Proteins. Edited by Kenneth H. Lundstrom.

Journal:

Year:

2008

Language:

english

File:

PDF, 107 KB

english, 2008

22

Structural Genomics and High Throughput Structural Biology. Edited by Michael Sundström, Martin Norin, and Aled Edwards.

Kenneth Lundstrom

Journal:

Year:

2008

Language:

english

File:

PDF, 82 KB

english, 2008

23

Cover Picture: CMP-Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway in Campylobacter jejuni and Helicobacter pylori (ChemMedChem 1/2008)

David J. McNally, Ian C. Schoenhofen, R. Scott Houliston, Nam H. Khieu, Dennis M. Whitfield, Susan M. Logan, Harold C. Jarrell, Jean-Robert Brisson

Journal:

Year:

2008

Language:

english

File:

PDF, 63 KB

english, 2008

24

Spotlights on our sister journals: ChemMedChem 1/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

25

Preview: ChemMedChem 2/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 88 KB

english, 2008

26

Graphical Abstract: ChemMedChem 1/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 776 KB

english, 2008