Volume 3; Issue 12

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ChemMedChem
Volume 3; Issue 12

ChemMedChem

Volume 3; Issue 12

1

Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing

Urszula Uciechowska, Jörg Schemies, Robert C. Neugebauer, Elisabeth-Maria Huda, Martin L. Schmitt, Rene Meier, Eric Verdin, Manfred Jung, Wolfgang Sippl

Journal:

Year:

2008

Language:

english

File:

PDF, 563 KB

english, 2008

2

HER-2-Targeted Nanoparticle–Affibody Bioconjugates for Cancer Therapy

Frank Alexis, Pamela Basto, Etgar Levy-Nissenbaum, Aleksandar F. Radovic-Moreno, Liangfang Zhang, Eric Pridgen, Andrew Z. Wang, Shawn L. Marein, Katrina Westerhof, Linda K. Molnar, Omid C. Farokhzad

Journal:

Year:

2008

Language:

english

File:

PDF, 489 KB

english, 2008

3

Modeling of the Intestinal Peptide Transporter hPepT1 and Analysis of Its Transport Capacities by Docking and Pharmacophore Mapping

Alessandro Pedretti, Laura De Luca, Cristina Marconi, Gianpaolo Negrisoli, Giancarlo Aldini, Giulio Vistoli

Journal:

Year:

2008

Language:

english

File:

PDF, 686 KB

english, 2008

4

Norcantharidin Analogues: Synthesis, Anticancer Activity and Protein Phosphatase 1 and 2A Inhibition

Timothy A. Hill, Scott G. Stewart, Christopher P. Gordon, Stephen P. Ackland, Jayne Gilbert, Benjamin Sauer, Jennette A. Sakoff, Adam McCluskey

Journal:

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

5

Small-Molecule Inhibitors of PDK1

Christian Peifer, Dario R. Alessi

Journal:

Year:

2008

Language:

english

File:

PDF, 2.01 MB

english, 2008

6

Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors

Hartmut Schirok, Raimund Kast, Santiago Figueroa-Pérez, Samir Bennabi, Mark J. Gnoth, Achim Feurer, Heike Heckroth, Michael Thutewohl, Holger Paulsen, Andreas Knorr, Joachim Hütter, Mario Lobell, Klau

Journal:

Year:

2008

Language:

english

File:

PDF, 529 KB

english, 2008

7

Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria

Kimberly D. Grimes, Ying-Jie Lu, Yong-Mei Zhang, Vicki A. Luna, Julian G. Hurdle, Elizabeth I. Carson, Jianjun Qi, Sucheta Kudrimoti, Charles O. Rock, Richard E. Lee

Journal:

Year:

2008

Language:

english

File:

PDF, 297 KB

english, 2008

8

Efficient Cellular Labeling by CD44 Receptor-Mediated Uptake of Cationic Liposomes Functionalized with Hyaluronic Acid and Loaded with MRI Contrast Agents

Giovanna Esposito, Simonetta Geninatti Crich, Silvio Aime

Journal:

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

9

Ground State, Intermediate, and Multivalent Nucleotide Analogue Inhibitors of Cytidine 5′-Triphosphate Synthase

Scott D. Taylor, Faylene A. Lunn, Stephen L. Bearne

Journal:

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

10

Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore

Ann R. Hermone, James C. Burnett, Jonathan E. Nuss, Lyal E. Tressler, Tam L. Nguyen, Bogdan A. Šolaja, Jonathan L. Vennerstrom, James J. Schmidt, Peter Wipf, Sina Bavari, Rick Gussio

Journal:

Year:

2008

Language:

english

File:

PDF, 726 KB

english, 2008

11

Asymmetric Synthesis and Biological Evaluation of Glycosidic Prodrugs for a Selective Cancer Therapy

Lutz F. Tietze, J. Marian von Hof, Birgit Krewer, Michael Müller, Felix Major, Heiko J. Schuster, Ingrid Schuberth, Frauke Alves

Journal:

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

12

Bisphosphonated Benzoxazinorifamycin Prodrugs for the Prevention and Treatment of Osteomyelitis

Ranga Reddy, Evelyne Dietrich, Yanick Lafontaine, Tom J. Houghton, Odette Belanger, Anik Dubois, Francis F. Arhin, Ingrid Sarmiento, Ibtihal Fadhil, Karine Laquerre, Valerie Ostiguy, Dario Lehoux, Gre

Journal:

Year:

2008

Language:

english

File:

PDF, 247 KB

english, 2008

13

Hemisuccinate of 21-Hydroxy-6,19-Epoxyprogesterone: A Tissue-Specific Modulator of the Glucocorticoid Receptor

Lautaro D. Álvarez, Marcelo A. Martí, Adriana S. Veleiro, Rosana I. Misico, Darío A. Estrin, Adalí Pecci, Gerardo Burton

Journal:

Year:

2008

Language:

english

File:

PDF, 589 KB

english, 2008

14

Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia

Lech-Gustav Milroy, Giovanna Zinzalla, François Loiseau, Zizheng Qian, Giuseppe Prencipe, Chris Pepper, Chris Fegan, Steven V. Ley

Journal:

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

15

Dopamides, Vanillylamides, Ethanolamides, and Arachidonic Acid Amides of Anti-inflammatory and Analgesic Drug Substances as TRPV1 Ligands

Christian Sinning, Bernhard Watzer, Luciano De Petrocellis, Vincenzo Di Marzo, Peter Imming

Journal:

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

16

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

Thomas van Groen, Katja Wiesehan, Susanne A. Funke, Inga Kadish, Luitgard Nagel-Steger, Dieter Willbold

Journal:

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

17

Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

Robert D. Winefield, Ruth A. Entwistle, Travis B. Foland, Gerald H. Lushington, Richard H. Himes

Journal:

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

18

The Handbook of Nanomedicine. By Kewal K. Jain.

Mansoor M. Amiji

Journal:

Year:

2008

Language:

english

File:

PDF, 75 KB

english, 2008

19

Index 2008

Journal:

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

20

Cover Picture: Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors (ChemMedChem 12/2008)

Hartmut Schirok, Raimund Kast, Santiago Figueroa-Pérez, Samir Bennabi, Mark J. Gnoth, Achim Feurer, Heike Heckroth, Michael Thutewohl, Holger Paulsen, Andreas Knorr, Joachim Hütter, Mario Lobell, Klau

Journal:

Year:

2008

Language:

english

File:

PDF, 872 KB

english, 2008

21

Graphical Abstract: ChemMedChem 12/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 1.10 MB

english, 2008

22

Spotlights on our sister journals: ChemMedChem 12/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 365 KB

english, 2008

23

Preview: ChemMedChem 1/2009

Journal:

Year:

2008

Language:

english

File:

PDF, 84 KB

english, 2008