Volume 3; Issue 2

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ChemMedChem
Volume 3; Issue 2

ChemMedChem

Volume 3; Issue 2

1

Cis-Configured Aziridines Are New Pseudo-Irreversible Dual-Mode Inhibitors of Candida albicans Secreted Aspartic Protease 2

Björn Degel, Peter Staib, Sebastian Rohrer, Josef Scheiber, Erika Martina, Christian Büchold, Knut Baumann, Joachim Morschhäuser, Tanja Schirmeister

Journal:

Year:

2008

Language:

english

File:

PDF, 960 KB

english, 2008

2

The Treatment of Dyslipidemia—What's Left in the Pipeline?

Oliver Rau, Heiko Zettl, Laura Popescu, Dieter Steinhilber, Manfred Schubert-Zsilavecz

Journal:

Year:

2008

Language:

english

File:

PDF, 647 KB

english, 2008

3

Virtual Screening and Experimental Verification to Identify Potential Inhibitors of the ErmC Methyltransferase Responsible for Bacterial Resistance against Macrolide Antibiotics

Marcin Feder, Elzbieta Purta, Lukasz Koscinski, Sonja Čubrilo, Gordana Maravic Vlahovicek, Janusz M. Bujnicki

Journal:

Year:

2008

Language:

english

File:

PDF, 361 KB

english, 2008

4

Generation of Carrier Peptides for the Delivery of Nucleic Acid Drugs in Primary Cells

Robert Rennert, Ines Neundorf, Heinz-Georg Jahnke, Philipp Suchowerskyj, Pascal Dournaud, Andrea Robitzki, Annette G. Beck-Sickinger

Journal:

Year:

2008

Language:

english

File:

PDF, 872 KB

english, 2008

5

Sensitive, Selective, and Irreversible Inhibition of Cyclooxygenase-2 Activity by Copper

Seiichi Nagano, Ashley I. Bush

Journal:

Year:

2008

Language:

english

File:

PDF, 197 KB

english, 2008

6

A Composite Model for hERG Blockade

Christian Kramer, Bernd Beck, Jan M. Kriegl, Timothy Clark

Journal:

Year:

2008

Language:

english

File:

PDF, 704 KB

english, 2008

7

Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)-2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid—HYDIA

Thomas J. Woltering, Geo Adam, Philipp Huguenin, Jürgen Wichmann, Sabine Kolczewski, Silvia Gatti, Anne Bourson, James N. C. Kew, Grayson Richards, John A. Kemp, Vincent Mutel, Frédéric Knoflach

Journal:

Year:

2008

Language:

english

File:

PDF, 584 KB

english, 2008

8

Heteroaryl-Substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent and Selective Corticotropin-Releasing Factor Receptor-1 Antagonists

Fabio Maria Sabbatini, Romano Di Fabio, Yves St-Denis, Anna-Maria Capelli, Emiliano Castiglioni, Stefania Contini, Daniele Donati, Elettra Fazzolari, Gabriella Gentile, Fabrizio Micheli, Francesca Pav

Journal:

Year:

2008

Language:

english

File:

PDF, 218 KB

english, 2008

9

Synthesis, Biological Evaluation, and Molecular Modeling Studies of Rebeccamycin Analogues Modified in the Carbohydrate Moiety

Fabio Animati, Marco Berettoni, Mario Bigioni, Monica Binaschi, Patrizia Felicetti, Lorenzo Gontrani, Ottaviano Incani, Andrea Madami, Edith Monteagudo, Lauso Olivieri, Stefano Resta, Cristina Rossi,

Journal:

Year:

2008

Language:

english

File:

PDF, 657 KB

english, 2008

10

Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The “55 % Rule” Applied to Enzymes

Martina Zürcher, Thomas Gottschalk, Solange Meyer, Daniel Bur, François Diederich

Journal:

Year:

2008

Language:

english

File:

PDF, 406 KB

english, 2008

11

Identification of Putative Binding Sites of P-glycoprotein Based on its Homology Model

Christoph Globisch, Ilza K. Pajeva, Michael Wiese

Journal:

Year:

2008

Language:

english

File:

PDF, 2.59 MB

english, 2008

12

Modeling and Selection of Flexible Proteins for Structure-Based Drug Design: Backbone and Side Chain Movements in p38 MAPK

Jyothi Subramanian, Somesh Sharma, Chandrika B-Rao

Journal:

Year:

2008

Language:

english

File:

PDF, 496 KB

english, 2008

13

Antiproliferative Agents That Interfere with the Cell Cycle at the G1→S Transition: Further Development and Characterization of a Small Library of Stilbene-Derived Compounds

Daniela Pizzirani, Marinella Roberti, Andrea Cavalli, Stefania Grimaudo, Antonietta Di Cristina, Rosaria Maria Pipitone, Nicola Gebbia, Manlio Tolomeo, Maurizio Recanatini

Journal:

Year:

2008

Language:

english

File:

PDF, 482 KB

english, 2008

14

D-SAP: A New, Noncytotoxic, and Fully Protease Resistant Cell-Penetrating Peptide

Sílvia Pujals, Jimena Fernández-Carneado, M. Dolors Ludevid, Ernest Giralt

Journal:

Year:

2008

Language:

english

File:

PDF, 929 KB

english, 2008

15

A Small Molecular Scaffold for Selective Inhibition of Wip1 Phosphatase

Jeong Bang, Hiroshi Yamaguchi, Stewart R. Durell, Ettore Appella, Daniel H. Appella

Journal:

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

16

Synthesis and Immobilization of erythro-C14-ω-Aminosphingosine-1-phosphate as a Potential Tool for Affinity Chromatography

Thomas Ullrich, Michael Ghobrial, Carsten Peters, Andreas Billich, Danilo Guerini, Peter Nussbaumer

Journal:

Year:

2008

Language:

english

File:

PDF, 210 KB

english, 2008

17

How Many Traditional Chinese Medicine Components Have Been Recognized by Modern Western Medicine? A Chemoinformatic Analysis and Implications for Finding Multicomponent Drugs

De-Xin Kong, Xue-Juan Li, Guang-Yan Tang, Hong-Yu Zhang

Journal:

Year:

2008

Language:

english

File:

PDF, 159 KB

english, 2008

18

Biochips as Pathways to Drug Discovery. Edited by Andrew Carmen and Gary Hardiman.

Matthew D. Disney

Journal:

Year:

2008

Language:

english

File:

PDF, 65 KB

english, 2008

19

Sport Doping—A Double Blind Proposal

Journal:

Year:

2008

Language:

english

File:

PDF, 79 KB

english, 2008

20

Cover Picture: A Composite Model for hERG Blockade (ChemMedChem 2/2008)

Christian Kramer, Bernd Beck, Jan M. Kriegl, Timothy Clark

Journal:

Year:

2008

Language:

english

File:

PDF, 618 KB

english, 2008

21

Graphical Abstract: ChemMedChem 2/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 730 KB

english, 2008

22

Alkoxymethylenephosphonate Analogues of (Lyso)phosphatidic Acid Stimulate Signaling Networks Coupled to the LPA2 Receptor

Joanna Gajewiak, Ryoko Tsukahara, Tamotsu Tsukahara, Yuko Fujiwara, Shuanxing Yu, Yiling Lu, Mandi Murph, Gordon B. Mills, Gabor Tigyi, Glenn D. Prestwich

Journal:

Year:

2008

File:

PDF, 58 KB

2008

23

Spotlights on our sister journals: ChemMedChem 2/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 385 KB

english, 2008

24

Preview: ChemMedChem 3/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 75 KB

english, 2008

25

Amphiphilic NO-Donor Antioxidants

Konstantin Chegaev, Loretta Lazzarato, Barbara Rolando, Elisabetta Marini, Gloria V. Lopez, Massimo Bertinaria, Antonella Di Stilo, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2008

File:

PDF, 69 KB

2008