Volume 3; Issue 6

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ChemMedChem
Volume 3; Issue 6

ChemMedChem

Volume 3; Issue 6

1

Towards an Integrated Description of Hydrogen Bonding and Dehydration: Decreasing False Positives in Virtual Screening with the HYDE Scoring Function

Ingo Reulecke, Gudrun Lange, Jürgen Albrecht, Robert Klein, Matthias Rarey

Journal:

Year:

2008

Language:

english

File:

PDF, 846 KB

english, 2008

2

Synthesis and Biological Activity of a Novel Inhibitor of Dihydroceramide Desaturase

Jose M. Munoz-Olaya, Xavier Matabosch, Carmen Bedia, Meritxell Egido-Gabás, Josefina Casas, Amadeu Llebaria, Antonio Delgado, Gemma Fabriàs

Journal:

Year:

2008

Language:

english

File:

PDF, 401 KB

english, 2008

3

Targeted RNA Interference of Cyclin A2 Mediated by Functionalized Single-Walled Carbon Nanotubes Induces Proliferation Arrest and Apoptosis in Chronic Myelogenous Leukemia K562 Cells

Xiaohui Wang, Jinsong Ren, Xiaogang Qu

Journal:

Year:

2008

Language:

english

File:

PDF, 311 KB

english, 2008

4

Discovery of a Drug-Like G-Quadruplex Binding Ligand by High-Throughput Docking

Dik-Lung Ma, Tat-Shing Lai, Fung-Yi Chan, Wai-Hong Chung, R. Abagyan, Yun-Chung Leung, Kwok-Yin Wong

Journal:

Year:

2008

Language:

english

File:

PDF, 332 KB

english, 2008

5

A Combinatorial Approach to 2,4,6-Trisubstituted Triazines with Potent Antimalarial Activity: Combining Conventional Synthesis and Microwave-Assistance

Sergio Melato, Davide Prosperi, Paolo Coghi, Nicoletta Basilico, Diego Monti

Journal:

Year:

2008

Language:

english

File:

PDF, 175 KB

english, 2008

6

Discovery of VHR Phosphatase Inhibitors with Micromolar Activity based on Structure-Based Virtual Screening

Hwangseo Park, Suk-Kyeong Jung, Dae Gwin Jeong, Seong Eon Ryu, Seung Jun Kim

Journal:

Year:

2008

Language:

english

File:

PDF, 257 KB

english, 2008

7

Herceptin–Platinum(II) Binding Complexes: Novel Cancer-Cell-Specific Agents

Jian Gao, Ya Guang Liu, Renbin Liu, Ralph A. Zingaro

Journal:

Year:

2008

Language:

english

File:

PDF, 640 KB

english, 2008

8

Substituted Pyrazolo[3,4-b]pyridines as Potent A1 Adenosine Antagonists: Synthesis, Biological Evaluation, and Development of an A1 Bovine Receptor Model

Tiziano Tuccinardi, Silvia Schenone, Francesco Bondavalli, Chiara Brullo, Olga Bruno, Luisa Mosti, Alessandra Tania Zizzari, Cristina Tintori, Fabrizio Manetti, Osele Ciampi, Maria Letizia Trincavelli

Journal:

Year:

2008

Language:

english

File:

PDF, 805 KB

english, 2008

9

Towards Small-Molecule CXCR3 Ligands with Clinical Potential

Maikel Wijtmans, Dennis Verzijl, Rob Leurs, Iwan J. P. de Esch, Martine J. Smit

Journal:

Year:

2008

Language:

english

File:

PDF, 539 KB

english, 2008

10

Investigating Amine Derivatives of Ambruticin VS-5 and VS-4

Zong-Qiang Tian, Zhan Wang, Yuan Xu, Chau Q. Tran, David C. Myles, Ziyang Zhong, Jessica Simmons, Leandro Vetcher, Leonard Katz, Yong Li, Simon J. Shaw

Journal:

Year:

2008

Language:

english

File:

PDF, 225 KB

english, 2008

11

On the Way to Selective PARP-2 Inhibitors. Design, Synthesis, and Preliminary Evaluation of a Series of Isoquinolinone Derivatives

Roberto Pellicciari, Emidio Camaioni, Gabriele Costantino, Laura Formentini, Paola Sabbatini, Francesco Venturoni, Gökçen Eren, Daniele Bellocchi, Alberto Chiarugi, Flavio Moroni

Journal:

Year:

2008

Language:

english

File:

PDF, 497 KB

english, 2008

12

Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity

Cledir Santos, José Morais, Luís Gouveia, Erik de Clercq, Christophe Pannecouque, Carsten Uhd Nielsen, Bente Steffansen, Rui Moreira, Paula Gomes

Journal:

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

13

The Art of Drug Synthesis. Edited by Douglas S. Johnson and Jie Jack Li.

Stefan Peukert, Branko Radetich

Journal:

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

14

Drug Discovery Research: New Frontiers in the Post-Genomic Era. Edited by Ziwei Huang.

William A. Barton

Journal:

Year:

2008

Language:

english

File:

PDF, 83 KB

english, 2008

15

Conformationally Restricted Hydantoin-Based Peptidomimetics as Inhibitors of Caspase-3 with Basic Groups Allowed at the S3 Enzyme Subsite

Jesús Vázquez, Alicia García-Jareño, Laura Mondragón, Jaime Rubio-Martinez, Enrique Pérez-Payá, Fernando Albericio

Journal:

Year:

2008

Language:

english

File:

PDF, 288 KB

english, 2008

16

Inhibitors of Inducible NO Synthase Expression: Total Synthesis of (S)-Curvularin and Its Ring Homologues

Stephan Elzner, Denise Schmidt, Dieter Schollmeyer, Gerhard Erkel, Timm Anke, Hartmut Kleinert, Ulrich Förstermann, Horst Kunz

Journal:

Year:

2008

Language:

english

File:

PDF, 483 KB

english, 2008

17

Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation

Antonio Garofalo, Fedora Grande, Antonella Brizzi, Francesca Aiello, Raveendra Dayam, Nouri Neamati

Journal:

Year:

2008

Language:

english

File:

PDF, 239 KB

english, 2008

18

Molecular Recognition of Small-Cell Lung Cancer Cells Using Aptamers

Hui William Chen, Colin D. Medley, Kwame Sefah, Dihua Shangguan, Zhiwen Tang, Ling Meng, Josh E. Smith, Weihong Tan

Journal:

Year:

2008

Language:

english

File:

PDF, 852 KB

english, 2008

19

Prodrugs: Challenges and Rewards. Parts 1 and 2. Edited by Valentino J. Stella, Ronald T. Borchardt, Michael J. Hageman, Reza Oliyai, Hans Maag, and Jefferson W. Tilley.

Journal:

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

20

Preview: ChemMedChem 7/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 131 KB

english, 2008

21

Cover Picture: Herceptin–Platinum(II) Binding Complexes: Novel Cancer-Cell-Specific Agents (ChemMedChem 6/2008)

Jian Gao, Ya Guang Liu, Renbin Liu, Ralph A. Zingaro

Journal:

Year:

2008

Language:

english

File:

PDF, 841 KB

english, 2008

22

Graphical Abstract: ChemMedChem 6/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 713 KB

english, 2008

23

Spotlights on our sister journals: ChemMedChem 6/2008

Journal:

Year:

2008

Language:

english

File:

PDF, 313 KB

english, 2008