Volume 4; Issue 4

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ChemMedChem
Volume 4; Issue 4

ChemMedChem

Volume 4; Issue 4

1

Replacement of the 4′-Hydroxy Group of Amodiaquine and Amopyroquine by Aromatic and Aliphatic Substituents: Synthesis and Antimalarial Activity

Emilia Păunescu, Sophie Susplugas, Emmanuelle Boll, Richard Varga, Elisabeth Mouray, Ion Grosu, Philippe Grellier, Patricia Melnyk

Journal:

Year:

2009

Language:

english

File:

PDF, 667 KB

english, 2009

2

Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-potentiator ADX-47273

Darren W. Engers, Alice L. Rodriguez, Richard Williams, Alexis S. Hammond, Daryl Venable, Oluwatomi Oluwatola, Gary A. Sulikowski, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Year:

2009

Language:

english

File:

PDF, 305 KB

english, 2009

3

Glycopeptide Dendrimers with High Affinity for the Fucose-Binding Lectin LecB from Pseudomonas aeruginosa

Elena Kolomiets, Magdalena A. Swiderska, Rameshwar U. Kadam, Emma M. V. Johansson, Karl-Erich Jaeger, Tamis Darbre, Jean-Louis Reymond

Journal:

Year:

2009

Language:

english

File:

PDF, 313 KB

english, 2009

4

CypScore: Quantitative Prediction of Reactivity toward Cytochromes P450 Based on Semiempirical Molecular Orbital Theory

Matthias Hennemann, Arno Friedl, Mario Lobell, Jörg Keldenich, Alexander Hillisch, Timothy Clark, Andreas H. Göller

Journal:

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

5

Structure and Function of Benzoylurea-Derived α-Helix Mimetics Targeting the Bcl-xL/Bak Binding Interface

Johanna M. Rodriguez, Nathan T. Ross, William P. Katt, Deepali Dhar, Gui-in Lee, Andrew D. Hamilton

Journal:

Year:

2009

Language:

english

File:

PDF, 809 KB

english, 2009

6

Development and Characterization of Peptidic Fusion Inhibitors Derived from HIV-1 gp41 with Partial D-Amino Acid Substitutions

Fabrice Gaston, Giovana C. Granados, Sergio Madurga, Francesc Rabanal, Faouzi Lakhdar-Ghazal, Ernest Giralt, Elmostafa Bahraoui

Journal:

Year:

2009

Language:

english

File:

PDF, 621 KB

english, 2009

7

Structure–Activity Relationships of SSAO/VAP-1 Arylalkylamine-Based Substrates

Francesc Yraola, Antonio Zorzano, Fernando Albericio, Miriam Royo

Journal:

Year:

2009

Language:

english

File:

PDF, 498 KB

english, 2009

8

Structure–Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine

Stefano Rizzo, Andrea Cavalli, Luisa Ceccarini, Manuela Bartolini, Federica Belluti, Alessandra Bisi, Vincenza Andrisano, Maurizio Recanatini, Angela Rampa

Journal:

Year:

2009

Language:

english

File:

PDF, 679 KB

english, 2009

9

Synthesis and Structure–Activity Relationships of 1-Benzyl-4,5,6-trimethoxyindoles as a Novel Class of Potent Antimitotic Agents

Mei-Jung Lai, Ching-Chuan Kuo, Teng-Kuang Yeh, Hsing-Pang Hsieh, Li-Tzong Chen, Wen-Yu Pan, Kuang-Yang Hsu, Jang-Yang Chang, Jing-Ping Liou

Journal:

Year:

2009

Language:

english

File:

PDF, 241 KB

english, 2009

10

Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic β-Turn Templates and Validation as 3D Scaffolds

Luca Gentilucci, Giuliana Cardillo, Alessandra Tolomelli, Rossella De Marco, Andrea Garelli, Santi Spampinato, Antonino Spartà, Eusebio Juaristi

Journal:

Year:

2009

Language:

english

File:

PDF, 387 KB

english, 2009

11

Improving the Search Performance of Extended Connectivity Fingerprints through Activity-Oriented Feature Filtering and Application of a Bit-Density-Dependent Similarity Function

Ye Hu, Eugen Lounkine, Jürgen Bajorath

Journal:

Year:

2009

Language:

english

File:

PDF, 327 KB

english, 2009

12

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

Jens-Uwe Peters, Patrick Schnider, Patrizio Mattei, Manfred Kansy

Journal:

Year:

2009

Language:

english

File:

PDF, 586 KB

english, 2009

13

Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationships

Kin-Fai Chan, Yunzhe Zhao, Toby W. S. Chow, Clare S. W. Yan, Dik Lung Ma, Brendan A. Burkett, Iris L. K. Wong, Larry M. C. Chow, Tak Hang Chan

Journal:

Year:

2009

Language:

english

File:

PDF, 457 KB

english, 2009

14

Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors

Stéphanie Kolb, Odile Mondésert, Mary-Lorène Goddard, Denis Jullien, Bruno O. Villoutreix, Bernard Ducommun, Christiane Garbay, Emmanuelle Braud

Journal:

Year:

2009

Language:

english

File:

PDF, 531 KB

english, 2009

15

Design, Synthesis, and Biological Evaluation of Levoglucosenone-Derived Ras Activation Inhibitors

Christian Müller, Maria Antonia Gomez-Zurita Frau, Dario Ballinari, Sonia Colombo, Alessandro Bitto, Enzo Martegani, Cristina Airoldi, Anske Stephanie van Neuren, Matthias Stein, Jörg Weiser, Carlo Ba

Journal:

Year:

2009

Language:

english

File:

PDF, 459 KB

english, 2009

16

A Click Approach to Structurally Diverse Conjugates Containing a Central Di-1,2,3-triazole Metal Chelate

Thomas L. Mindt, Christian Schweinsberg, Luc Brans, Adelheid Hagenbach, Ulrich Abram, Dirk Tourwé, Elisa Garcia-Garayoa, Roger Schibli

Journal:

Year:

2009

Language:

english

File:

PDF, 359 KB

english, 2009

17

Cyclic RGD-Containing Functionalized Azabicycloalkane Peptides as Potent Integrin Antagonists for Tumor Targeting

Leonardo Manzoni, Laura Belvisi, Daniela Arosio, Monica Civera, Michael Pilkington-Miksa, Donatella Potenza, Andrea Caprini, Elena M. V. Araldi, Eugenia Monferini, Monica Mancino, Francesca Podestà, C

Journal:

Year:

2009

Language:

english

File:

PDF, 567 KB

english, 2009

18

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Edited by Benjamin Bonavidia.

Yoshihiko Kotake

Journal:

Year:

2009

Language:

english

File:

PDF, 104 KB

english, 2009

19

Induction of a Melanoma-Specific Antibody Response by a Monovalent, but not a Divalent, Synthetic GM2 Neoglycopeptide

S. Bay, S. Fort, L. Birikaki, C. Ganneau, E. Samain, Y-M. Coïc, F. Bonhomme, E. Dériaud, C. Leclerc, R. Lo-Man

Journal:

Year:

2009

Language:

english

File:

PDF, 356 KB

english, 2009

20

Cover Picture: Inhibition of Peroxidase-Catalyzed Iodination by Cephalosporins: Metallo-β-Lactamase-Induced Antithyroid Activity of Antibiotics (ChemMedChem 4/2009)

A. Tamilselvi, Govindasamy Mugesh

Journal:

Year:

2009

File:

PDF, 877 KB

2009

21

Inside Cover: Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors (ChemMedChem 4/2009)

Stéphanie Kolb, Odile Mondésert, Mary-Lorène Goddard, Denis Jullien, Bruno O. Villoutreix, Bernard Ducommun, Christiane Garbay, Emmanuelle Braud

Journal:

Year:

2009

File:

PDF, 380 KB

2009

22

Graphical Abstract: ChemMedChem 4/2009

Journal:

Year:

2009

Language:

english

File:

PDF, 977 KB

english, 2009

23

Preview: ChemMedChem 5/2009

Journal:

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

24

Inhibition of Peroxidase-Catalyzed Iodination by Cephalosporins: Metallo-β-Lactamase-Induced Antithyroid Activity of Antibiotics

A. Tamilselvi, Govindasamy Mugesh

Journal:

Year:

2009

Language:

english

File:

PDF, 250 KB

english, 2009

25

Spotlights on our sister journals: ChemMedChem 4/2009

Journal:

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

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