Volume 5; Issue 4

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ChemMedChem
Volume 5; Issue 4

ChemMedChem

Volume 5; Issue 4

1

Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes

Matteo Colombo, Stefania Vallese, Ilaria Peretto, Xavier Jacq, Jean-Christophe Rain, Frédéric Colland, Philippe Guedat

Journal:

Year:

2010

Language:

english

File:

PDF, 328 KB

english, 2010

2

Inhibition of Human DHODH by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)anthranilic Acids Identified by Structure-Guided Fragment Selection

Ingela Fritzson, Bo Svensson, Salam Al-Karadaghi, Björn Walse, Ulf Wellmar, Ulf J. Nilsson, Dorthe da Graça Thrige, Stig Jönsson

Journal:

Year:

2010

Language:

english

File:

PDF, 643 KB

english, 2010

3

Anticancer Activity of Vitamin E-Derived Compounds in Murine C6 Glioma Cells

Francesco Mazzini, Michele Betti, Barbara Canonico, Thomas Netscher, Francesca Luchetti, Stefano Papa, Francesco Galli

Journal:

Year:

2010

Language:

english

File:

PDF, 230 KB

english, 2010

4

Synthesis of N-Hydroxycinnamides Capped with a Naturally Occurring Moiety as Inhibitors of Histone Deacetylase

Wei-Jan Huang, Ching-Chow Chen, Shi-Wei Chao, Shoei-Sheng Lee, Fen-Lin Hsu, Yeh-Lin Lu, Ming-Fang Hung, Chung-I Chang

Journal:

Year:

2010

Language:

english

File:

PDF, 514 KB

english, 2010

5

A Structure-Based Virtual Screening Approach toward the Discovery of Histone Deacetylase Inhibitors: Identification of Promising Zinc-Chelating Groups

Hwangseo Park, Sukyoung Kim, Yong Eun Kim, Soo-Jeong Lim

Journal:

Year:

2010

Language:

english

File:

PDF, 532 KB

english, 2010

6

Understanding Kinase Selectivity Through Energetic Analysis of Binding Site Waters

Daniel D. Robinson, Woody Sherman, Ramy Farid

Journal:

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

7

Synthesis of Thia-Analogous Indirubin N-Glycosides and their Influence on Melanoma Cell Growth and Apoptosis

Manfred Kunz, Katrin M. Driller, Martin Hein, Stephanie Libnow, Ina Hohensee, Robert Ramer, Burkhard Hinz, Anja Berger, Jürgen Eberle, Peter Langer

Journal:

Year:

2010

Language:

english

File:

PDF, 491 KB

english, 2010

8

Development of a Benzopyran-Containing Androgen Receptor Antagonist to Treat Antiandrogen-Resistant Prostate Cancer

Sangmi Oh, Hye Jin Nam, Jongmin Park, Sung Hee Beak, Seung Bum Park

Journal:

Year:

2010

Language:

english

File:

PDF, 418 KB

english, 2010

9

Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library

Samu Melkko, Luca Mannocci, Christoph E. Dumelin, Alessandra Villa, Roberto Sommavilla, Yixin Zhang, Markus G. Grütter, Nadine Keller, Lutz Jermutus, Ronald H. Jackson, Jörg Scheuermann, Dario Neri

Journal:

Year:

2010

Language:

english

File:

PDF, 916 KB

english, 2010

10

Peptide Architecture: Adding an α-Helix to the PYY Lysine Side Chain Provides Nanomolar Binding and Body-Weight-Lowering Effects

Søren L. Pedersen, Pottayil G. Sasikumar, Niels Vrang, Knud J. Jensen

Journal:

Year:

2010

Language:

english

File:

PDF, 413 KB

english, 2010

11

Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes

Claudia Pessoa, Paulo Michel P. Ferreira, Letícia Veras C. Lotufo, Manoel O. de Moraes, Suellen M. T. Cavalcanti, Lucas Cunha D. Coêlho, Marcelo Z. Hernandes, Ana Cristina L. Leite, Carlos A. De Simon

Journal:

Year:

2010

Language:

english

File:

PDF, 346 KB

english, 2010

12

Design and In vitro Evaluation of Branched Peptide Conjugates: Turning Nonspecific Cytotoxic Drugs into Tumor-Selective Agents

Chiara Falciani, Jlenia Brunetti, Chiara Pagliuca, Stefano Menichetti, Lucia Vitellozzi, Barbara Lelli, Alessandro Pini, Luisa Bracci

Journal:

Year:

2010

Language:

english

File:

PDF, 316 KB

english, 2010

13

Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

Colm D. Duffy, Paola Maderna, Ciara McCarthy, Christine E. Loscher, Catherine Godson, Patrick J. Guiry

Journal:

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

14

Taking Quinazoline as a General Support-Nog to Design Potent and Selective Kinase Inhibitors: Application to FMS-like Tyrosine Kinase 3

Wei-Wei Li, Jin-Juan Chen, Ren-Lin Zheng, Wen-Qin Zhang, Zhi-Xing Cao, Ling-Ling Yang, Xiao-Yu Qing, Liang-Xue Zhou, Li Yang, Luo-Ding Yu, Li-Juan Chen, Yu-Quan Wei, Sheng-Yong Yang

Journal:

Year:

2010

Language:

english

File:

PDF, 264 KB

english, 2010

15

Rational Design, Synthesis, Biophysical and Antiproliferative Evaluation of Fluorenone Derivatives with DNA G-Quadruplex Binding Properties

Stefano Alcaro, Anna Artese, James N. Iley, Sotiris Missailidis, Francesco Ortuso, Lucia Parrotta, Raffaele Pasceri, Francesco Paduano, Claudia Sissi, Francesco Trapasso, Maria Gabriella Vigorita

Journal:

Year:

2010

Language:

english

File:

PDF, 633 KB

english, 2010

16

Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

Stefan Peukert, Karen Miller-Moslin

Journal:

Year:

2010

Language:

english

File:

PDF, 656 KB

english, 2010

17

Synthesis of 9,9-Dialkyl-4,5-diazafluorene Derivatives and Their Structure–Activity Relationships Toward Human Carcinoma Cell Lines

Qiwei Wang, Marcus Chun-Wah Yuen, Guo-Liang Lu, Cheuk-Lam Ho, Gui-Jiang Zhou, Oi-Mei Keung, Kim-Hung Lam, Roberto Gambari, Xiao-Ming Tao, Raymond Siu-Ming Wong, See-Wai Tong, Kit-Wah Chan, Fung-Yi Lau

Journal:

Year:

2010

Language:

english

File:

PDF, 513 KB

english, 2010

18

Cover Picture: Peptide Architecture: Adding an α-Helix to the PYY Lysine Side Chain Provides Nanomolar Binding and Body-Weight-Lowering Effects (ChemMedChem 4/2010)

Søren L. Pedersen, Pottayil G. Sasikumar, Niels Vrang, Knud J. Jensen

Journal:

Year:

2010

File:

PDF, 876 KB

2010

19

Inside Cover: Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes (ChemMedChem 4/2010)

Claudia Pessoa, Paulo Michel P. Ferreira, Letícia Veras C. Lotufo, Manoel O. de Moraes, Suellen M. T. Cavalcanti, Lucas Cunha D. Coêlho, Marcelo Z. Hernandes, Ana Cristina L. Leite, Carlos A. De Simon

Journal:

Year:

2010

Language:

english

File:

PDF, 430 KB

english, 2010

20

Graphical Abstract: ChemMedChem 4/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 1.84 MB

english, 2010

21

Spotlights on our sister journals: ChemMedChem 4/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 767 KB

english, 2010

22

Preview: ChemMedChem 5/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 81 KB

english, 2010

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