Volume 5; Issue 8

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ChemMedChem
Volume 5; Issue 8

ChemMedChem

Volume 5; Issue 8

1

Modelling Inhalational Anaesthetics Using Bayesian Feature Selection and QSAR Modelling Methods

David T. Manallack, Frank R. Burden, David A. Winkler

Journal:

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

2

Exploring the ‘RPRL’ Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues

N. J. Maximilian Macaluso, Robert C. Glen

Journal:

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

3

Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors

Marco Radi, Emmanuele Crespan, Federico Falchi, Vincenzo Bernardo, Samantha Zanoli, Fabrizio Manetti, Silvia Schenone, Giovanni Maga, Maurizio Botta

Journal:

Year:

2010

Language:

english

File:

PDF, 408 KB

english, 2010

4

Recent Advances in Endomorphin Engineering

Attila Keresztes, Attila Borics, Géza Tóth

Journal:

Year:

2010

Language:

english

File:

PDF, 679 KB

english, 2010

5

Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

Maria Laura Bolognesi, Manuela Bartolini, Francesca Mancini, Gianpaolo Chiriano, Luisa Ceccarini, Michela Rosini, Andrea Milelli, Vincenzo Tumiatti, Vincenza Andrisano, Carlo Melchiorre

Journal:

Year:

2010

Language:

english

File:

PDF, 319 KB

english, 2010

6

A Structure–Activity Relationship Study of the Antimalarial and Antileishmanial Activities of Nonpeptide Macrocyclic Histone Deacetylase Inhibitors

William Guerrant, Sandra C. Mwakwari, Po C. Chen, Shabana I. Khan, Babu L. Tekwani, Adegboyega K. Oyelere

Journal:

Year:

2010

Language:

english

File:

PDF, 183 KB

english, 2010

7

Synthesis, 3D-QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D2 and D3 Receptors

Laura López, Jana Selent, Raquel Ortega, Christian F. Masaguer, Eduardo Domínguez, Filipe Areias, José Brea, María Isabel Loza, Ferran Sanz, Manuel Pastor

Journal:

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

8

Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

Leticia Cubo, Michael Groessl, Paul J. Dyson, Adoración G. Quiroga, Carmen Navarro-Ranninger, Angela Casini

Journal:

Year:

2010

Language:

english

File:

PDF, 407 KB

english, 2010

9

Discovery of Carboranes as Inducers of 20S Proteasome Activity

Hyun Seung Ban, Hidemitsu Minegishi, Kazuki Shimizu, Minako Maruyama, Yuka Yasui, Hiroyuki Nakamura

Journal:

Year:

2010

Language:

english

File:

PDF, 287 KB

english, 2010

10

Novel Monocyclam Derivatives as HIV Entry Inhibitors: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with the CXCR4 Co-receptor

Sofia Pettersson, Violeta I. Pérez-Nueno, Maria Pau Mena, Bonaventura Clotet, José A. Esté, José I. Borrell, Jordi Teixidó

Journal:

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

11

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

John Gatfield, Catherine Brisbare-Roch, Francois Jenck, Christoph Boss

Journal:

Year:

2010

Language:

english

File:

PDF, 913 KB

english, 2010

12

Discovery of a Class of Diketopiperazines as Antiprion Compounds

Maria Laura Bolognesi, Hoang Ngoc Ai Tran, Matteo Staderini, Alessandra Monaco, Alberto López-Cobeñas, Salvatore Bongarzone, Xevi Biarnés, Pilar López-Alvarado, Nieves Cabezas, Maria Caramelli, Paolo

Journal:

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

13

Off-Target Effects Related to the Phosphorothioate Modification of Nucleic Acids

Johannes Winkler, Martina Stessl, Jennifer Amartey, Christian R. Noe

Journal:

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

14

Inhibition of Eimeria tenella CDK-Related Kinase 2: From Target Identification to Lead Compounds

Kristin Engels, Carsten Beyer, Maria L. Suárez Fernández, Frank Bender, Michael Gaßel, Gottfried Unden, Richard J. Marhöfer, Jeremy C. Mottram, Paul M. Selzer

Journal:

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

15

Structure-Based Virtual Screening and Electrophysiological Evaluation of New Chemotypes of Kv1.5 Channel Blockers

Qian Yang, David Fedida, Hongjian Xu, Binghe Wang, Lupei Du, Xiaojian Wang, Minyong Li, Qidong You

Journal:

Year:

2010

Language:

english

File:

PDF, 492 KB

english, 2010

16

Hit Identification and Biological Evaluation of Anticancer Pyrazolopyrimidines Endowed with Anti-inflammatory Activity

Stefano Alcaro, Anna Artese, Maurizio Botta, Alessandra T. Zizzari, Francisco Orallo, Francesco Ortuso, Silvia Schenone, Chiara Brullo, Matilde Yáñez

Journal:

Year:

2010

Language:

english

File:

PDF, 299 KB

english, 2010

17

Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors

Florian Thaler, Mario Varasi, Andrea Colombo, Roberto Boggio, Davide Munari, Nickolas Regalia, Marco G. Rozio, Veronica Reali, Anna E. Resconi, Antonello Mai, Stefania Gagliardi, Giulio Dondio, Saveri

Journal:

Year:

2010

Language:

english

File:

PDF, 351 KB

english, 2010

18

The Role of Fluorine Atoms in a Fluorinated Prostaglandin Agonist

Ken-ichi Fujimura, Yoshimasa Sasabuchi

Journal:

Year:

2010

Language:

english

File:

PDF, 607 KB

english, 2010

19

Synthesis and in vitro Evaluation of 3H-Pyrrolo[3,2-f]quinolin-9-one Derivatives That Show Potent and Selective Anti-leukemic Activity

Maria Grazia Ferlin, Roberta Bortolozzi, Paola Brun, Ignazio Castagliuolo, Ernest Hamel, Giuseppe Basso, Giampietro Viola

Journal:

Year:

2010

Language:

english

File:

PDF, 662 KB

english, 2010

20

HTS and Rational Drug Design to Generate a Class of 5-HT2C-Selective Ligands for Possible Use in Schizophrenia.

Alan P. Kozikowski, Sung Jin Cho, Niels H. Jensen, John A. Allen, Andreas M. Svennebring, Bryan L. Roth

Journal:

Year:

2010

Language:

english

File:

PDF, 386 KB

english, 2010

21

CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases

Pavla Spáčilová, Petr Nauš, Radek Pohl, Ivan Votruba, Jan Snášel, Helena Zábranská, Iva Pichová, Ria Ameral, Gabriel Birkuš, Tomáš Cihlář, Michal Hocek

Journal:

Year:

2010

Language:

english

File:

PDF, 378 KB

english, 2010

22

Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena. Edited by Masood N. Khan and John W. Findlay.

Claudiu Supuran

Journal:

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

23

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

Richard K. Haynes, Wing-Chi Chan, Ho-Ning Wong, Ka-Yan Li, Wai-Keung Wu, Kit-Man Fan, Herman H. Y. Sung, Ian D. Williams, Davide Prosperi, Sergio Melato, Paolo Coghi, Diego Monti

Journal:

Year:

2010

Language:

english

File:

PDF, 913 KB

english, 2010

24

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery. Edited by Taosheng Chen.

Journal:

Year:

2010

Language:

english

File:

PDF, 127 KB

english, 2010

25

“Hot Spots” in Medicinal Chemistry

Rainer Metternich, Giorgio Tarzia

Journal:

Year:

2010

Language:

english

File:

PDF, 285 KB

english, 2010

26

Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)

Maria Laura Bolognesi, Hoang Ngoc Ai Tran, Matteo Staderini, Alessandra Monaco, Alberto López-Cobeñas, Salvatore Bongarzone, Xevi Biarnés, Pilar López-Alvarado, Nieves Cabezas, Maria Caramelli, Paolo

Journal:

Year:

2010

Language:

english

File:

PDF, 996 KB

english, 2010

27

Inside Cover: Inhibition of Eimeria tenella CDK-Related Kinase 2: From Target Identification to Lead Compounds (ChemMedChem 8/2010)

Kristin Engels, Carsten Beyer, Maria L. Suárez Fernández, Frank Bender, Michael Gaßel, Gottfried Unden, Richard J. Marhöfer, Jeremy C. Mottram, Paul M. Selzer

Journal:

Year:

2010

Language:

english

File:

PDF, 635 KB

english, 2010

28

Graphical Abstract: ChemMedChem 8/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 866 KB

english, 2010

29

Spotlights on our sister journals: ChemMedChem 8/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 774 KB

english, 2010

30

Preview: ChemMedChem 9/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010